MAZZON AGURTO, ENRICO
Preferred name
MAZZON AGURTO, ENRICO
Main Affiliation
Email
emazzon@udd.cl
ORCID
0000-0001-7662-8556
Scopus Author ID
57214689246
19 results
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Item type:Publication, Cervical Artery Dissections with and without stroke, risk factors and prognosis: a Chilean prospective cohort(2020); ;D. Rocha; ;C. De la BarraX. Stecher3Scopus© Citations 15 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effects of an Avocado-based Mediterranean Diet on Serum Lipids for Secondary Prevention after Ischemic Stroke Trial (ADD-SPISE)(2021); ; ;Valeska Vollrath ;Paula von GeldernCarolina Velásquez2Scopus© Citations 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 2Scopus© Citations 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Scopus© Citations 2 1 - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, 3Scopus© Citations 9 - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Association between spontaneous internal carotid artery dissection and perivascular adipose tissue attenuation on computed tomography angiography(2023) ;Kevin Cheng ;Andrew Lin; ;Tomas BernsteinPaulo Zuñiga<jats:sec><jats:title>Background:</jats:title><jats:p> Spontaneous cervical artery dissection (sCAD) is a leading cause of ischemic stroke in young patients. Studies using high-resolution magnetic resonance imaging and positron emission tomography have suggested vessel wall inflammation to be a pathogenic factor in sCAD. Computed tomography (CT) attenuation of perivascular adipose tissue (PVAT) is an established non-invasive imaging biomarker of inflammation in coronary arteries, with higher attenuation values reflecting a greater degree of vascular inflammation. </jats:p></jats:sec><jats:sec><jats:title>Objectives:</jats:title><jats:p> We evaluate the CT attenuation of PVAT surrounding the internal carotid artery (PVAT<jats:sub>carotid</jats:sub>) with and without spontaneous dissection. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> Single-center prospective observational study of 56 consecutive patients with CT-verified spontaneous dissection of the internal carotid artery (ICA). Of these patients, six underwent follow-up computed tomography angiography (CTA). Twenty-two patients who underwent CTA for acute neurological symptoms but did not have dissection formed the control group. Using semi-automated research software, PVAT<jats:sub>carotid</jats:sub> was measured as the mean Hounsfield unit (HU) attenuation of adipose tissue within a defined volume of interest surrounding the ICA. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> PVAT<jats:sub>carotid</jats:sub> was significantly higher around dissected ICA compared with non-dissected contralateral ICA in the same patients (−58.7 ± 10.2 vs −68.9 ± 8.1 HU, p < 0.0001) and ICA of patients without dissection (−58.7 ± 10.2 vs −69.3 ± 9.3 HU, p < 0.0001). After a median follow-up of 89 days, there was a significant reduction in PVAT<jats:sub>carotid</jats:sub> around dissected ICA (−57.5 ± 13.4 to −74.3 ± 10.5 HU, p < 0.05), while no change was observed around non-dissected contralateral ICA (−71.0 ± 4.4 to −74.1 ± 4.1 HU, p = 0.19). ICA dissection was an independent predictor of PVAT<jats:sub>carotid</jats:sub> following multivariable adjustment for age and the presence of ICA occlusion. </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> PVAT<jats:sub>carotid</jats:sub> is elevated in the presence of sCAD and may decrease following the acute event. </jats:p></jats:sec>3 1Scopus© Citations 12 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pre-stroke adherence to a Mediterranean diet pattern is associated with lower acute ischemic stroke severity: a cross-sectional analysis of a prospective hospital-register study(2020) ;Pablo M. Lavados; ;Alexis Rojo; <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>High adherence to a Mediterranean Diet is associated with reduced incidence and mortality of acute ischemic stroke (AIS) but may also be associated with severity. Our purpose was to investigate the association of adherence to a Mediterranean diet and severity in a prospective hospital register of AIS patients.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>We included AIS patients admitted from February 2017 to July 2019. All were assessed by a neurologist with a standard stroke protocol, including NIHSS. Adherence to Mediterranean diet was prospectively measured by the 14-point Mediterranean Diet Adherence Screener (MEDAS) and defined as low (0–6 points) or high (7–14 points). Demographic and clinical characteristics were compared by group with univariate analysis. A Generalized Linear Model (GLM) was used to investigate the association of admission NIHSS as a continuous ordinal variable and an ordinal logistic regression (OLR) analysis to determine the independent association of the NIHSS quartiles with adherence to Mediterranean diet.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Three hundred sixty-eight patients were included, mean age 68.3 (17.7), 158 (42.9%) females. The median NIHSS score was 3 (IQR 1–9) and the median MEDAS score was 6 (IQR 4.5–8). Patients with high MEDAS scores had significantly lower; admission NIHSS scores, sedentary lifestyle, body mass index, total and LDL cholesterol levels, but higher alcohol consumption. After adjustments, high adherence to Mediterranean diet remained independently associated with lower stroke severity both in the GLM (β coefficient = − 0.19, <jats:italic>p</jats:italic> = 0.01) and in the OLR model (OR for lower NIHSS quartiles 0.6 (95% CI 0.37–0.98, <jats:italic>p</jats:italic> = 0.04).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Higher pre-stroke adherence to a Mediterranean diet is independently associated with lower AIS severity.</jats:p> </jats:sec>1Scopus© Citations 15