BRUNSER RABOVICH, ALEJANDRO MICHEL
Preferred name
BRUNSER RABOVICH, ALEJANDRO MICHEL
Main Affiliation
Email
abrunser@alemana.cl
ORCID
0000-0002-8376-9450
Scopus Author ID
26644722200
75 results
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Item type:Publication, Validation of transcranial Doppler in the diagnosis of brain death(2010-04); ; ; Roldán, Andrés1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Timing of Tissue-plasminogen-activator Induced Recanalization and Functional Recovery in Acute Ischemic Stroke.(2019); 6 - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Additional Information Given to a Multimodal Imaging Stroke Protocol by Transcranial Doppler Ultrasound in the Emergency Room: A Prospective Observational Study(2010); ; ; <jats:p><i>Background:</i> Transcranial Doppler (TCD) ultrasound can demonstrate dynamic information. We aimed to evaluate whether TCD generates useful additional information in the emergency room after a multimodal stroke imaging protocol and also whether this modified the management of patients with cerebral infarction. <i>Methods:</i> Patients admitted between April 2006 and June 2007 with ischemic stroke of less than 24 h were subjected to a protocol consisting of noncontrast brain CT, computed tomography angiography, diffusion-weighted magnetic resonance imaging and then TCD within the following 6 h by an observer blinded to the results of imaging studies. <i>Results:</i> Seventy-nine patients were included. The imaging protocol was performed 457 (±346) min after stroke symptoms and TCD after 572 (±376) min. TCD provided additional information in 28 cases (35.4%, 95% CI 25.7–46.4). More that one piece of additional information was obtained in 6 patients. The most frequent additional information was collateral pathways. Multivariate analysis demonstrated that intracranial vessel occlusion was the variable most associated with additional information. In 7 patients (8.8%, 95% CI 4.3–17.1), additional information changed management: in 4 an additional angiography was performed, in 2 patients angiography was suspended and in 1 aggressive neurocritical care was indicated. Patients with NIHSS >10 were significantly more likely to have their initial treatment changed (p = 0.004). <i>Conclusions:</i> TCD can provide additional information to a multimodal acute ischemic stroke imaging protocol in a third of patients. This can result in changes in the management in some of these patients.</jats:p>2Scopus© Citations 17 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Latin American Consensus Statement for the Use of Contrast-Enhanced Transcranial Ultrasound as a Diagnostic Test for Detection of Right-to-Left Shunt(2019)48Scopus© Citations 19 - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Head position and cerebral blood flow in acute ischemic stroke patients: Protocol for the pilot phase, cluster randomized, Head Position in Acute Ischemic Stroke Trial (HeadPoST pilot)(2016); ; ; Scopus© Citations 11 3 - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Statistical analysis plan of the head position in acute ischemic stroke trial pilot (HEADPOST pilot)(2017); ; <jats:sec><jats:title>Background</jats:title><jats:p> The HEADPOST Pilot is a proof-of-concept, open, prospective, multicenter, international, cluster randomized, phase IIb controlled trial, with masked outcome assessment. The trial will test if lying flat head position initiated in patients within 12 h of onset of acute ischemic stroke involving the anterior circulation increases cerebral blood flow in the middle cerebral arteries, as measured by transcranial Doppler. The study will also assess the safety and feasibility of patients lying flat for ≥24 h. The trial was conducted in centers in three countries, with ability to perform early transcranial Doppler. A feature of this trial was that patients were randomized to a certain position according to the month of admission to hospital. </jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p> To outline in detail the predetermined statistical analysis plan for HEADPOST Pilot study. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> All data collected by participating researchers will be reviewed and formally assessed. Information pertaining to the baseline characteristics of patients, their process of care, and the delivery of treatments will be classified, and for each item, appropriate descriptive statistical analyses are planned with comparisons made between randomized groups. For the outcomes, statistical comparisons to be made between groups are planned and described. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> This statistical analysis plan was developed for the analysis of the results of the HEADPOST Pilot study to be transparent, available, verifiable, and predetermined before data lock. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> We have developed a statistical analysis plan for the HEADPOST Pilot study which is to be followed to avoid analysis bias arising from prior knowledge of the study findings. </jats:p></jats:sec><jats:sec><jats:title>Trial registration</jats:title><jats:p> The study is registered under HEADPOST-Pilot, ClinicalTrials.gov Identifier NCT01706094. </jats:p></jats:sec>2