RECULE GONZALEZ, FRANCISCA
Preferred name
RECULE GONZALEZ, FRANCISCA
Main Affiliation
Email
frecule@udd.cl
ORCID
0000-0002-1731-2153
Scopus Author ID
57193331909
26 results
Now showing 1 - 10 of 26
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, Cutaneous mastocytosis in children [Mastocitosis cutáneas en la edad pediátrica](2017) ;MarĂa Trinidad HasbĂşn Zegpi2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Lupus eritematoso sistĂ©mico buloso: Una manifestaciĂłn infrecuente en poblaciĂłn pediátrica(2021) ;MarĂa Trinidad HasbĂşn Z.; ;Ximena Chaparro R. ;Cecilia Fischer S.Adriana CastrillĂłn V.<jats:p>El lupus eritematoso sistĂ©mico buloso (LESB) es una enfermedad ampollar subepidĂ©rmica autoinmune secundaria a la presencia de autoanticuerpos contra el colágeno VII de la membrana basal. Es considerada una variante de lupus eritematoso sistĂ©mico (LES), siendo infrecuente en la poblaciĂłn pediátrica.Objetivo: Describir caso de paciente pediátrica con erupciĂłn ampollar compatible con LESB.Caso ClĂnico: Paciente de sexo femenino de 16 años de ascendencia mapuche, con antecedentes de LES diagnosticado a los 10 años de edad, en tratamiento. ConsultĂł por erupciĂłn vesiculobulosa generalizada de 6 semanas de evoluciĂłn, sin sintomatologĂa sistĂ©mica. Se realizĂł biopsia para estudio histolĂłgico e inmunofluorescencia directa (IFD), confirmándose el diagnĂłstico de LESB. La paciente respondiĂł favorablemente al tratamiento con dapsona en dosis de 100 mg/dĂa (asociado a su tratamiento de base), sin nuevas reactivaciones a 8 años de seguimiento.ConclusiĂłn: El LESB es una manifestaciĂłn infrecuente de LES. Aunque la clĂnica es similar a la de otras dermatosis ampollares, la correlaciĂłn entre la presencia de LES, los hallazgos histopatolĂłgicos y de IFD permiten confirmar el diagnĂłstico. Si bien se ha reportado mayor riesgo de LES en poblaciĂłn de ascendencia indĂgena, faltan estudios respecto a la asociaciĂłn de LESB en esta etnia.</jats:p>Scopus© Citations 2 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial(2023) ;Lu Ma ;Xin Hu ;Lili Song ;Xiaoying ChenMenglu OuyangScopus© Citations 221 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A solitary nodule in the palm of a newborn(2022) ;HasbĂşn Zegpi, MarĂa ;Britzmann, Joanna; ;Alfaro-SepĂşlveda, Daniela2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Orbital vascular malformation: Successful outcome in two patients treated with rapamycin(2022); ;Rosario Agüero ;Ximena Chaparro ;Cecilia FischerTrinidad HasbúnScopus© Citations 1 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Skin collision tumour and dermoscopic diagnosis of melanoma
<i>in situ</i>
and dilated pore of Winer(2021); ;Paloma Matus ;Gabriela Coulon; 41 1Scopus© Citations 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Flat-head positioning increases cerebral blood flow in anterior circulation acute ischemic stroke. A cluster randomized phase IIb trial<jats:sec><jats:title>Background</jats:title><jats:p> Whether lying-flat improves blood flow in patients with acute ischemic stroke is unknown. Our aim was to investigate if lying-flat “changes” cerebral blood flow velocities assessed by transcranial Doppler in acute ischemic stroke patients. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> In a multicenter cluster clinical trial, we randomly assigned patients within 12 h from onset of a neurological deficit due to cerebral ischemia of the anterior circulation to lying-flat or upright head positioning. The primary outcome was a change of 8 cm/s or more in mean cerebral blood flow velocities on transcranial Doppler to the middle cerebral artery at 1 and 24 h post-randomization, adjusted for imbalance in baseline variables. Secondary outcomes included serious adverse events and physical functioning at 90 days. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Ninety-four of 304 patients screened were recruited. The primary outcome occurred in 11 (26%) of 43 patients in the lying-flat group and in 6 (12%) of 51 in the upright group at 1 h (adjusted odds ratio, 3.81; 95% CI, 1.07 to 13.54), and in 23 (53%) and 18 (36%) patients in these respective groups at 24 h (adjusted odds ratio, 3.04; 95% CI, 1.08 to 8.53). There were no between-group differences in serious adverse events, including pneumonia, heart failure or mortality, nor in functional outcome at 3 months (adjusted common odds ratio, 1.38; 95% CI 0.64 to 3.00). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> The lying-flat head position was associated with a significant increase in cerebral blood flow velocities at one and 24 h within the ipsilateral hemisphere of anterior circulation acute ischemic stroke, without serious safety concerns. Clinical trial registration-URL: http://www.clinicaltrials.gov . Unique identifier: NCT01706094. </jats:p></jats:sec>Scopus© Citations 23 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Foliculitis necrosante linfocĂtica como primer signo clĂnico de presentaciĂłn del sida(Elsevier BV, 2026-03); ;MarĂa Hubner-GarretĂłn; ; 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The main Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMISTmain): Protocol for a Pragmatic, Stepped Wedge, Cluster Randomized Controlled Trial(2023) ;Menglu Ouyang ;Roland Faigle ;Xia Wang ;Brenda JohnsonDebbie Summers<jats:p>Introduction: Careful monitoring of patients who receive intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) is resource-intensive, and potentially less relevant in those with mild degrees of neurological impairment who are at low risk of symptomatic intracerebral hemorrhage (sICH) and other complications. Methods: OPTIMISTmain is an international, multicenter, prospective, stepped wedge, cluster randomized, blinded outcome assessed trial aims to determine whether a less-intensity monitoring protocol is at least as effective, safe, and efficient as standard post-IVT monitoring in patients with mild deficits post-AIS. Clinically stable adult patients with mild AIS (defined by a NIHSS &lt;10) who do not require intensive care within 2 h post-IVT are recruited at hospitals in Australia, Chile, China, Malaysia, Mexico, UK, USA, and Vietnam. An average of 15 patients recruited per period (overall 60 patient participants) at 120 sites for a total of 7,200 IVT-treated AIS patients will provide 90% power (one-sided α 0.025). The initiation of eligible hospitals is based on a rolling process whenever ready, stratified by country. Hospitals are randomly allocated using permuted blocks into 3 sequences of implementation, stratified by country and the projected number of patients to be recruited over 12 months. These sequences have four periods that dictate the order in which they are to switch from control (usual care) to intervention (implementation of low intensity monitoring protocol) to different clusters of patients in a stepped manner. Compared to standard monitoring, the low-intensity monitoring protocol includes assessments of neurological and vital signs every 15 min for 2 h, 2 hourly (vs. every 30 min) for 8 h, and 4 hourly (vs. every 1 h) until 24 h, post-IVT. The primary outcome measure is functional recovery, defined by the modified Rankin scale (mRS) at 90 days, a seven-point ordinal scale (0 [no residual symptom] to 6 [death]). Secondary outcomes include death or dependency, length of hospital stay, and health-related quality of life, sICH, and serious adverse events. Conclusion: OPTIMISTmain will provide level I evidence for the safety and effectiveness of a low-intensity post-IVT monitoring protocol in patients with mild severity of AIS. </jats:p>3Scopus© Citations 4