Pre-stroke adherence to a Mediterranean diet pattern is associated with lower acute ischemic stroke severity: a cross-sectional analysis of a prospective hospital-register study
Journal
BMC Neurology
ISSN
1471-2377
Date Issued
2020
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Background</jats:title>
<jats:p>High adherence to a Mediterranean Diet is associated with reduced incidence and mortality of acute ischemic stroke (AIS) but may also be associated with severity. Our purpose was to investigate the association of adherence to a Mediterranean diet and severity in a prospective hospital register of AIS patients.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>We included AIS patients admitted from February 2017 to July 2019. All were assessed by a neurologist with a standard stroke protocol, including NIHSS. Adherence to Mediterranean diet was prospectively measured by the 14-point Mediterranean Diet Adherence Screener (MEDAS) and defined as low (0–6 points) or high (7–14 points). Demographic and clinical characteristics were compared by group with univariate analysis. A Generalized Linear Model (GLM) was used to investigate the association of admission NIHSS as a continuous ordinal variable and an ordinal logistic regression (OLR) analysis to determine the independent association of the NIHSS quartiles with adherence to Mediterranean diet.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>Three hundred sixty-eight patients were included, mean age 68.3 (17.7), 158 (42.9%) females. The median NIHSS score was 3 (IQR 1–9) and the median MEDAS score was 6 (IQR 4.5–8). Patients with high MEDAS scores had significantly lower; admission NIHSS scores, sedentary lifestyle, body mass index, total and LDL cholesterol levels, but higher alcohol consumption. After adjustments, high adherence to Mediterranean diet remained independently associated with lower stroke severity both in the GLM (β coefficient = − 0.19, <jats:italic>p</jats:italic> = 0.01) and in the OLR model (OR for lower NIHSS quartiles 0.6 (95% CI 0.37–0.98, <jats:italic>p</jats:italic> = 0.04).</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>Higher pre-stroke adherence to a Mediterranean diet is independently associated with lower AIS severity.</jats:p>
</jats:sec>
<jats:title>Background</jats:title>
<jats:p>High adherence to a Mediterranean Diet is associated with reduced incidence and mortality of acute ischemic stroke (AIS) but may also be associated with severity. Our purpose was to investigate the association of adherence to a Mediterranean diet and severity in a prospective hospital register of AIS patients.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>We included AIS patients admitted from February 2017 to July 2019. All were assessed by a neurologist with a standard stroke protocol, including NIHSS. Adherence to Mediterranean diet was prospectively measured by the 14-point Mediterranean Diet Adherence Screener (MEDAS) and defined as low (0–6 points) or high (7–14 points). Demographic and clinical characteristics were compared by group with univariate analysis. A Generalized Linear Model (GLM) was used to investigate the association of admission NIHSS as a continuous ordinal variable and an ordinal logistic regression (OLR) analysis to determine the independent association of the NIHSS quartiles with adherence to Mediterranean diet.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>Three hundred sixty-eight patients were included, mean age 68.3 (17.7), 158 (42.9%) females. The median NIHSS score was 3 (IQR 1–9) and the median MEDAS score was 6 (IQR 4.5–8). Patients with high MEDAS scores had significantly lower; admission NIHSS scores, sedentary lifestyle, body mass index, total and LDL cholesterol levels, but higher alcohol consumption. After adjustments, high adherence to Mediterranean diet remained independently associated with lower stroke severity both in the GLM (β coefficient = − 0.19, <jats:italic>p</jats:italic> = 0.01) and in the OLR model (OR for lower NIHSS quartiles 0.6 (95% CI 0.37–0.98, <jats:italic>p</jats:italic> = 0.04).</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>Higher pre-stroke adherence to a Mediterranean diet is independently associated with lower AIS severity.</jats:p>
</jats:sec>
Cite this document
Lavados, P. M., Mazzon, E., Rojo, A., Brunser, A. M., & Olavarría, V. V. (2020). Pre-stroke adherence to a Mediterranean diet pattern is associated with lower acute ischemic stroke severity: A cross-sectional analysis of a prospective hospital-register study. BMC Neurology, 20(1), 252. https://doi.org/10.1186/s12883-020-01824-y
Subjects
acute stroke
;
adherence
;
ischemic stroke
;
mediterranean diet
;
severity
;
aged
;
cross-sectional studies
;
diet, mediterranean
;
female
;
humans
;
logistic models
;
male
;
middle aged
;
prospective studies
;
severity of illness index
;
stroke
;
cholesterol
;
low density lipoprotein cholesterol
;
aged
;
alcohol consumption
;
article
;
body mass
;
brain ischemia
;
chile
;
cross-sectional study
;
demography
;
dietary compliance
;
disease severity
;
female
;
hospital admission
;
human
;
major clinical study
;
male
;
mediterranean diet
;
national institutes of health stroke scale
;
neurologist
;
prospective study
;
register
;
sedentary lifestyle
;
teaching hospital
;
univariate analysis
;
cerebrovascular accident
;
middle aged
;
pathology
;
pathophysiology
;
severity of illness index
;
statistical model