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Item type:Publication, Reduction of nicotine and ethanol intake in alcohol-preferring (UChB) female rats by the α4β2 nicotinic acetylcholine receptor partial agonists 5-bromocytisine and cytisine(2023) ;María Elena Quintanilla ;Mario Rivera-Meza ;Pablo Berríos-CárcamoBruce K. CasselsScopus© Citations 2 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Chronic Voluntary Morphine Intake Is Associated with Changes in Brain Structures Involved in Drug Dependence in a Rat Model of Polydrug Use(2023) ;María Elena Quintanilla ;Paola Morales ;Daniela Santapau ;Alba ÁvilaCarolina Ponce<jats:p>Chronic opioid intake leads to several brain changes involved in the development of dependence, whereby an early hedonistic effect (liking) extends to the need to self-administer the drug (wanting), the latter being mostly a prefrontal–striatal function. The development of animal models for voluntary oral opioid intake represents an important tool for identifying the cellular and molecular alterations induced by chronic opioid use. Studies mainly in humans have shown that polydrug use and drug dependence are shared across various substances. We hypothesize that an animal bred for its alcohol preference would develop opioid dependence and further that this would be associated with the overt cortical abnormalities clinically described for opioid addicts. We show that Wistar-derived outbred UChB rats selected for their high alcohol preference additionally develop: (i) a preference for oral ingestion of morphine over water, resulting in morphine intake of 15 mg/kg/day; (ii) marked opioid dependence, as evidenced by the generation of strong withdrawal signs upon naloxone administration; (iii) prefrontal cortex alterations known to be associated with the loss of control over drug intake, namely, demyelination, axonal degeneration, and a reduction in glutamate transporter GLT-1 levels; and (iv) glial striatal neuroinflammation and brain oxidative stress, as previously reported for chronic alcohol and chronic nicotine use. These findings underline the relevance of polydrug animal models and their potential in the study of the wide spectrum of brain alterations induced by chronic morphine intake. This study should be valuable for future evaluations of therapeutic approaches for this devastating condition.</jats:p>7Scopus© Citations 9 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Aspirin and N‐acetylcysteine co‐administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation‐oxidative stress self‐perpetuation(2019) ;Yedy Israel ;María Elena Quintanilla; ;Paola MoralesDaniela SantapauScopus© Citations 34 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A dual treatment blocks alcohol binge-drinking relapse: Microbiota as a new player(2022); ;María Elena Quintanilla ;Paola Morales ;Daniela SantapauScopus© Citations 22 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, N-Acetylcysteine and Acetylsalicylic Acid Inhibit Alcohol Consumption by Different Mechanisms: Combined Protection(2020) ;María Elena Quintanilla; ;Paola Morales; Scopus© Citations 21 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats(2019); ;María Elena Quintanilla ;Paola Morales; Carolyne Lespay-Rebolledo1Scopus© Citations 31 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking(2019); ;María Elena Quintanilla ;Paola Morales ;Daniela Santapau1Scopus© Citations 60 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options(2019) ;María Elena Quintanilla; ;Paola Morales ;Daniela Santapau14Scopus© Citations 28