Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats

Ezquer, F., Quintanilla, M. E., Morales, P., Ezquer, M., Lespay‐Rebolledo, C., Herrera‐Marschitz, M., & Israel, Y. (2019). Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse‐like drinking in high‐alcohol drinker rats. Addiction Biology, 24(1), 17-27. https://doi.org/10.1111/adb.12572

Project(s)

Evaluation of the therapeutic effect of mesenchymal stem cell acelular derivate on drug induced steatosis, in model of normal and impaired liver regeneration capacity

Treating the whole not the hole: Administration of acellular derivative from mesenchymal stem cells subjected to a preconditioning stimulus reverts diabetic neuropathy and prevents diabetic foot ulcers in an animal model of type 2 diabetes mellitus

Subjects

alcohol preferring rats

;

alcoholism

;

binge drinking

;

gfap

;

glutathione

;

lps

;

oxidative stress

;

tnf-alpha

;

alcohol drinking

;

alcoholism

;

animals

;

astrocytes

;

binge drinking

;

brain

;

central nervous system depressants

;

chronic disease

;

ethanol

;

glial fibrillary acidic protein

;

humans

;

inflammation

;

lateral ventricles

;

mesenchymal stem cell transplantation

;

rats

;

recurrence

;

self administration

;

5' nucleotidase

;

beta1 integrin

;

endoglin

;

glial fibrillary acidic protein

;

indoleamine 2,3 dioxygenase

;

interleukin 10

;

interleukin 5

;

microsomal aminopeptidase

;

reactive oxygen metabolite

;

thy 1 membrane glycoprotein

;

tumor necrosis factor receptor associated factor 6

;

alcohol

;

central depressant agent

;

gfap protein, rat

;

glial fibrillary acidic protein

;

adult

;

alcohol blood level

;

alcohol consumption

;

alcoholism

;

animal experiment

;

animal model

;

animal tissue

;

antiinflammatory activity

;

article

;

astrocyte

;

cell activation

;

controlled study

;

female

;

hippocampus

;

human

;

human cell

;

immunoreactivity

;

mesenchymal stem cell

;

microscopy

;

molecular imaging

;

nervous system inflammation

;

nonhuman

;

priority journal

;

rat

;

tissue level

;

treatment duration

;

withdrawal syndrome

;

alcoholism

;

animal

;

binge drinking

;

brain

;

chronic disease

;

drinking behavior

;

drug self administration

;

immunology

;

inflammation

;

lateral brain ventricle

;

mesenchymal stem cell transplantation

;

recurrent disease