Project Title
Evaluation of the therapeutic effect of mesenchymal stem cell acelular derivate on drug induced steatosis, in model of normal and impaired liver regeneration capacity
Partner Organisations
Internal ID
1150589
Principal Investigator
Type
basic research
Status
TERMINADO
Start Date
March 15, 2015
End Date
March 18, 2015
Investigators
Fernando Ezquer
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Item type:Publication, Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking(2018); ;Paola Morales ;MarĂa Elena Quintanilla ;Carolyne Lespay-RebolledoDaniela Santapau1Scopus© Citations 43 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats(2016) ;Yedy Israel; ;MarĂa Elena Quintanilla ;Paola Morales7Scopus© Citations 19 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats(2019); ;MarĂa Elena Quintanilla ;Paola Morales; Carolyne Lespay-Rebolledo1Scopus© Citations 31 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis(2016) ;Johanna Abrigo ;Juan Carlos Rivera ;Javier Aravena ;Daniel CabreraFelipe Simon<jats:p>Obesity can lead to skeletal muscle atrophy, a pathological condition characterized by the loss of strength and muscle mass. A feature of muscle atrophy is a decrease of myofibrillar proteins as a result of ubiquitin proteasome pathway overactivation, as evidenced by increased expression of the muscle-specific ubiquitin ligases atrogin-1 and MuRF-1. Additionally, other mechanisms are related to muscle wasting, including oxidative stress, myonuclear apoptosis, and autophagy. Stem cells are an emerging therapy in the treatment of chronic diseases such as high fat diet-induced obesity. Mesenchymal stem cells (MSCs) are a population of self-renewable and undifferentiated cells present in the bone marrow and other mesenchymal tissues of adult individuals. The present study is the first to analyze the effects of systemic MSC administration on high fat diet-induced skeletal muscle atrophy in the tibialis anterior of mice. Treatment with MSCs reduced losses of muscle strength and mass, decreases of fiber diameter and myosin heavy chain protein levels, and fiber type transitions. Underlying these antiatrophic effects, MSC administration also decreased ubiquitin proteasome pathway activation, oxidative stress, and myonuclear apoptosis. These results are the first to indicate that systemically administered MSCs could prevent muscle wasting associated with high fat diet-induced obesity and diabetes.</jats:p>6Scopus© Citations 94 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options(2019) ;Yedy Israel ;Quintanilla, MarĂa Elena ;Paola Ezquer ;Mario MoralesEduardo Rivera-Meza26Scopus© Citations 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Scopus© Citations 32 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking(2019); ;MarĂa Elena Quintanilla ;Paola Morales ;Daniela Santapau1Scopus© Citations 60 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line(2017) ;Yedy Israel ;Eduardo Karahanian; ;Paola MoralesScopus© Citations 28 1