Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking
Journal
Addiction Biology
ISSN
1355-6215
Date Issued
2019
Author(s)
María Elena Quintanilla
Paola Morales
Daniela Santapau
Marcelo J. Kogan
Edison Salas-Huenuleo
Mario Herrera-Marschitz
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Cite this document
Ezquer, F., Quintanilla, M. E., Morales, P., Santapau, D., Ezquer, M., Kogan, M. J., Salas‐Huenuleo, E., Herrera‐Marschitz, M., & Israel, Y. (2019). Intranasal delivery of mesenchymal stem cell‐derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post‐deprivation relapse drinking. Addiction Biology, 24(5), 994-1007. https://doi.org/10.1111/adb.12675
Project(s)
Subjects
ade
;
glt-1
;
binge-drinking
;
exosomes
;
mesenchymal stem cells
;
non-invasive
;
administration, intranasal
;
alcohol drinking
;
amino acid transport system x-ag
;
animals
;
astrocytes
;
chronic disease
;
exosomes
;
female
;
hippocampus
;
humans
;
injections, intraventricular
;
mesenchymal stem cell transplantation
;
microglia
;
nucleus accumbens
;
oxidative stress
;
prefrontal cortex
;
rats, wistar
;
rna, messenger
;
secondary prevention
;
subcutaneous fat
;
substance withdrawal syndrome
;
glutathione
;
vesicular glutamate transporter 1
;
glutamate transporter
;
messenger rna
;
alcohol consumption
;
alcohol withdrawal syndrome
;
alcoholism
;
animal cell
;
animal experiment
;
animal model
;
animal tissue
;
antioxidant activity
;
article
;
astrocyte
;
binge drinking
;
biological therapy
;
cell activation
;
cell density
;
cell fusion
;
cell membrane
;
controlled study
;
exosome
;
experimental alcoholism
;
female
;
hippocampus
;
human
;
human cell
;
human tissue
;
injection
;
intranasal delivery
;
intranasal exosome administration
;
membrane microparticle
;
mesenchymal stem cell
;
microglia
;
nervous system inflammation
;
neuroprotection
;
nonhuman
;
nucleus accumbens
;
oxidation
;
oxidative stress
;
particle size
;
priority journal
;
protein expression
;
rat
;
relapse
;
treatment duration
;
animal
;
chronic disease
;
cytology
;
drinking behavior
;
exosome
;
intracerebroventricular drug administration
;
intranasal drug administration
;
mesenchymal stem cell transplantation
;
metabolism
;
oxidative stress
;
pathophysiology
;
physiology
;
prefrontal cortex
;
prevention and control
;
procedures
;
secondary prevention
;
subcutaneous fat
;
transplantation
;
wistar rat
;
withdrawal syndrome