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  4. Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking
Details

Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking

Journal
Addiction Biology
ISSN
1355-6215
Date Issued
2019
Author(s)
EZQUER, EDUARDO FERNANDO  
Facultad de Medicina Clínica Alemana Universidad del Desarrollo  
María Elena Quintanilla
Paola Morales
Daniela Santapau
Facultad de Medicina Clínica Alemana Universidad del Desarrollo  
EZQUER, EDUARDO MARCELO  
Facultad de Medicina Clínica Alemana Universidad del Desarrollo  
Marcelo J. Kogan
Edison Salas-Huenuleo
Mario Herrera-Marschitz
Yedy Israel
Facultad de Medicina Clínica Alemana Universidad del Desarrollo  
Type
Resource Types::text::journal::journal article
Scopus ID
2-s2.0-85053680914
WoS ID
WOS:000480622000013
DOI
10.1111/adb.12675
URL
https://investigadores.udd.cl/handle/123456789/2708
URL Institutional Repository
http://hdl.handle.net/11447/3214
Cite this document
Ezquer, F., Quintanilla, M. E., Morales, P., Santapau, D., Ezquer, M., Kogan, M. J., Salas‐Huenuleo, E., Herrera‐Marschitz, M., & Israel, Y. (2019). Intranasal delivery of mesenchymal stem cell‐derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post‐deprivation relapse drinking. Addiction Biology, 24(5), 994-1007. https://doi.org/10.1111/adb.12675
Project(s)
Evaluation of the therapeutic effect of mesenchymal stem cell acelular derivate on drug induced steatosis, in model of normal and impaired liver regeneration capacity  
Treating the whole not the hole: Administration of acellular derivative from mesenchymal stem cells subjected to a preconditioning stimulus reverts diabetic neuropathy and prevents diabetic foot ulcers in an animal model of type 2 diabetes mellitus  
The Oxidative stress-neuroinflammation Synergy: Role in the perpetuation of alcohol intake and therapeutic avenues  
Subjects
ade

; 

glt-1

; 

binge-drinking

; 

exosomes

; 

mesenchymal stem cells

; 

non-invasive

; 

administration, intranasal

; 

alcohol drinking

; 

amino acid transport system x-ag

; 

animals

; 

astrocytes

; 

chronic disease

; 

exosomes

; 

female

; 

hippocampus

; 

humans

; 

injections, intraventricular

; 

mesenchymal stem cell transplantation

; 

microglia

; 

nucleus accumbens

; 

oxidative stress

; 

prefrontal cortex

; 

rats, wistar

; 

rna, messenger

; 

secondary prevention

; 

subcutaneous fat

; 

substance withdrawal syndrome

; 

glutathione

; 

vesicular glutamate transporter 1

; 

glutamate transporter

; 

messenger rna

; 

alcohol consumption

; 

alcohol withdrawal syndrome

; 

alcoholism

; 

animal cell

; 

animal experiment

; 

animal model

; 

animal tissue

; 

antioxidant activity

; 

article

; 

astrocyte

; 

binge drinking

; 

biological therapy

; 

cell activation

; 

cell density

; 

cell fusion

; 

cell membrane

; 

controlled study

; 

exosome

; 

experimental alcoholism

; 

female

; 

hippocampus

; 

human

; 

human cell

; 

human tissue

; 

injection

; 

intranasal delivery

; 

intranasal exosome administration

; 

membrane microparticle

; 

mesenchymal stem cell

; 

microglia

; 

nervous system inflammation

; 

neuroprotection

; 

nonhuman

; 

nucleus accumbens

; 

oxidation

; 

oxidative stress

; 

particle size

; 

priority journal

; 

protein expression

; 

rat

; 

relapse

; 

treatment duration

; 

animal

; 

chronic disease

; 

cytology

; 

drinking behavior

; 

exosome

; 

intracerebroventricular drug administration

; 

intranasal drug administration

; 

mesenchymal stem cell transplantation

; 

metabolism

; 

oxidative stress

; 

pathophysiology

; 

physiology

; 

prefrontal cortex

; 

prevention and control

; 

procedures

; 

secondary prevention

; 

subcutaneous fat

; 

transplantation

; 

wistar rat

; 

withdrawal syndrome
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