BERRIOS CARCAMO, PABLO ANDRES

Preferred name

Main Affiliation

Facultad de Medicina Clínica Alemana Universidad del Desarrollo

pablo.berrios@udd.cl

ORCID

0000-0003-4875-4568

Scopus Author ID

55014632000

Goggle Scholar

https://scholar.google.com/citations?user=bJDTXDcAAAAJ&hl=es&oi=ao

Now showing 1 - 10 of 13

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Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options
(2019)
María Elena Quintanilla
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EZQUER, EDUARDO FERNANDO
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Paola Morales
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Daniela Santapau
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BERRIOS CARCAMO, PABLO ANDRES
14Scopus© Citations 29
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Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules
(2020)
BERRIOS CARCAMO, PABLO ANDRES
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Mauricio Quezada
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María Elena Quintanilla
;
Paola Morales
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EZQUER, EDUARDO MARCELO
<jats:p>Drug abuse is a major global health and economic problem. However, there are no pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse. Despite exerting different mechanisms of action, all drugs of abuse promote the activation of the brain reward system, with lasting neurobiological consequences that potentiate subsequent consumption. Recent evidence shows that the brain displays marked oxidative stress and neuroinflammation following chronic drug consumption. Brain oxidative stress and neuroinflammation disrupt glutamate homeostasis by impairing synaptic and extra-synaptic glutamate transport, reducing GLT-1, and system Xc− activities respectively, which increases glutamatergic neurotransmission. This effect consolidates the relapse-promoting effect of drug-related cues, thus sustaining drug craving and subsequent drug consumption. Recently, promising results as experimental treatments to reduce drug consumption and relapse have been shown by (i) antioxidant and anti-inflammatory synthetic molecules whose effects reach the brain; (ii) natural biomolecules secreted by mesenchymal stem cells that excel in antioxidant and anti-inflammatory properties, delivered via non-invasive intranasal administration to animal models of drug abuse and (iii) potent anti-inflammatory microRNAs and anti-miRNAs which target the microglia and reduce neuroinflammation and drug craving. In this review, we address the neurobiological consequences of brain oxidative stress and neuroinflammation that follow the chronic consumption of most drugs of abuse, and the current and potential therapeutic effects of antioxidants and anti-inflammatory agents and biomolecules to reduce these drug-induced alterations and to prevent relapse.</jats:p>
1Scopus© Citations 99
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Methadone directly impairs central nervous system cells in vitro
(2024)
Cristian De Gregorio
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Javiera Gallardo
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BERRIOS CARCAMO, PABLO ANDRES
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Álex Handy
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Daniela Santapau
Scopus© Citations 2 3
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PRENATAL METHADONE EXPOSURE REDUCES SOCIAL INTERACTION AND INCREASES ALCOHOL CONSUMPTION PREDISPOSITION IN MALE RATS, WHICH CAN BE PREVENTED BY EARLY ADMINISTRATION OF MESENCHYMAL STEM CELL-DERIVED SECRETOME
(2026)
EZQUER, EDUARDO FERNANDO
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CAROLINA ANDREA PONCE HENRIQUEZ
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GALLARDO ROJAS, JAVIERA CAROLINA
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RIVEROS VALLE, MARIA EUGENIA
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BERRIOS CARCAMO, PABLO ANDRES
3
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A Novel Morphine Drinking Model of Opioid Dependence in Rats
(2022)
BERRIOS CARCAMO, PABLO ANDRES
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Mauricio Quezada
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Daniela Santapau
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Paola Morales
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OLIVARES, MARIA BELEN
<jats:p>An animal model of voluntary oral morphine consumption would allow for a pre-clinical evaluation of new treatments aimed at reducing opioid intake in humans. However, the main limitation of oral morphine consumption in rodents is its bitter taste, which is strongly aversive. Taste aversion is often overcome by the use of adulterants, such as sweeteners, to conceal morphine taste or bitterants in the alternative bottle to equalize aversion. However, the adulterants’ presence is the cause for consumption choice and, upon removal, the preference for morphine is not preserved. Thus, current animal models are not suitable to study treatments aimed at reducing consumption elicited by morphine itself. Since taste preference is a learned behavior, just-weaned rats were trained to accept a bitter taste, adding the bitterant quinine to their drinking water for one week. The latter was followed by allowing the choice of quinine or morphine (0.15 mg/mL) solutions for two weeks. Then, quinine was removed, and the preference for morphine against water was evaluated. Using this paradigm, we show that rats highly preferred the consumption of morphine over water, reaching a voluntary morphine intake of 15 mg/kg/day. Morphine consumption led to significant analgesia and hyperlocomotion, and to a marked deprivation syndrome following the administration of the opioid antagonist naloxone. Voluntary morphine consumption was also shown to generate brain oxidative stress and neuroinflammation, signs associated with opioid dependence development. We present a robust two-bottle choice animal model of oral morphine self-administration for the evaluation of therapeutic interventions for the treatment of morphine dependence.</jats:p>
1Scopus© Citations 18
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Microfabrication-based engineering of biomimetic dentin-like constructs to simulate dental aging
(2024)
Simon Álvarez
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Jose Morales
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Paola Tiozzo-Lyon
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Pablo Berrios
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Valentina Barraza
<jats:p>Our study aimed to develop a novel <jats:italic>in vitro</jats:italic> microfabricated biomimetic dentin surface that simulates the complex surface microarchitecture of exposed dentin, as well as age-derived glycation of teeth, for the growth of polymicrobial oral biofilms.</jats:p>
7Scopus© Citations 6
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Dataset - Metabolomics Workbench
(Common Fund of the National Institutes of Health, 2022)
BERRIOS CARCAMO, PABLO ANDRES
8
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Two-Month Voluntary Ethanol Consumption Promotes Mild Neuroinflammation in the Cerebellum but Not in the Prefrontal Cortex, Hippocampus, or Striatum of Mice
(2024)
BERRIOS CARCAMO, PABLO ANDRES
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Sarah Núñez
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Justine Castañeda
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GALLARDO ROJAS, JAVIERA CAROLINA
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María Rosa Bono
<jats:p>Chronic ethanol exposure often triggers neuroinflammation in the brain’s reward system, potentially promoting the drive for ethanol consumption. A main marker of neuroinflammation is the microglia-derived monocyte chemoattractant protein 1 (MCP1) in animal models of alcohol use disorder in which ethanol is forcefully given. However, there are conflicting findings on whether MCP1 is elevated when ethanol is taken voluntarily, which challenges its key role in promoting motivation for ethanol consumption. Here, we studied MCP1 mRNA levels in areas implicated in consumption motivation—specifically, the prefrontal cortex, hippocampus, and striatum—as well as in the cerebellum, a brain area highly sensitive to ethanol, of C57BL/6 mice subjected to intermittent and voluntary ethanol consumption for two months. We found a significant increase in MCP1 mRNA levels in the cerebellum of mice that consumed ethanol compared to controls, whereas no significant changes were observed in the prefrontal cortex, hippocampus, or striatum or in microglia isolated from the hippocampus and striatum. To further characterize cerebellar neuroinflammation, we measured the expression changes in other proinflammatory markers and chemokines, revealing a significant increase in the proinflammatory microRNA miR-155. Notably, other classical proinflammatory markers, such as TNFα, IL6, and IL-1β, remained unaltered, suggesting mild neuroinflammation. These results suggest that the onset of neuroinflammation in motivation-related areas is not required for high voluntary consumption in C57BL/6 mice. In addition, cerebellar susceptibility to neuroinflammation may be a trigger to the cerebellar degeneration that occurs after chronic ethanol consumption in humans.</jats:p>
6Scopus© Citations 4
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Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice
(2022)
Georgia Charkoftaki
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Wan Ying Tan
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BERRIOS CARCAMO, PABLO ANDRES
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David J. Orlicky
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Jaya Prakash Golla
12Scopus© Citations 21
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Aspirin and N‐acetylcysteine co‐administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation‐oxidative stress self‐perpetuation
(2019)
Yedy Israel
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María Elena Quintanilla
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EZQUER, EDUARDO FERNANDO
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Paola Morales
;
Daniela Santapau
2Scopus© Citations 36

BERRIOS CARCAMO, PABLO ANDRES

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