GALLARDO ROJAS, JAVIERA CAROLINA
Preferred name
GALLARDO ROJAS, JAVIERA CAROLINA
Main Affiliation
Email
javi.gallardor@gmail.com
ORCID
0000-0001-6580-2336
Scopus Author ID
57197728177
4 results
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Item type:Publication, Two-Month Voluntary Ethanol Consumption Promotes Mild Neuroinflammation in the Cerebellum but Not in the Prefrontal Cortex, Hippocampus, or Striatum of Mice(2024); ; MarĂa Rosa Bono<jats:p>Chronic ethanol exposure often triggers neuroinflammation in the brain’s reward system, potentially promoting the drive for ethanol consumption. A main marker of neuroinflammation is the microglia-derived monocyte chemoattractant protein 1 (MCP1) in animal models of alcohol use disorder in which ethanol is forcefully given. However, there are conflicting findings on whether MCP1 is elevated when ethanol is taken voluntarily, which challenges its key role in promoting motivation for ethanol consumption. Here, we studied MCP1 mRNA levels in areas implicated in consumption motivation—specifically, the prefrontal cortex, hippocampus, and striatum—as well as in the cerebellum, a brain area highly sensitive to ethanol, of C57BL/6 mice subjected to intermittent and voluntary ethanol consumption for two months. We found a significant increase in MCP1 mRNA levels in the cerebellum of mice that consumed ethanol compared to controls, whereas no significant changes were observed in the prefrontal cortex, hippocampus, or striatum or in microglia isolated from the hippocampus and striatum. To further characterize cerebellar neuroinflammation, we measured the expression changes in other proinflammatory markers and chemokines, revealing a significant increase in the proinflammatory microRNA miR-155. Notably, other classical proinflammatory markers, such as TNFα, IL6, and IL-1β, remained unaltered, suggesting mild neuroinflammation. These results suggest that the onset of neuroinflammation in motivation-related areas is not required for high voluntary consumption in C57BL/6 mice. In addition, cerebellar susceptibility to neuroinflammation may be a trigger to the cerebellar degeneration that occurs after chronic ethanol consumption in humans.</jats:p>Scopus© Citations 2 6 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Reticulon-1 synthesis controls outgrowth and microtubule dynamics in injured cortical axons(Life Science Alliance, LLC, 2026-01-16); 5 - Some of the metrics are blocked by yourconsent settings
Item type:Product, Dataset - Gut Microbiota-Derived Extracellular Vesicles Influence Alcohol Intake Preferences in Rats(United States National Library of Medicine, 2025); ; CRISTIAN ALEJANDRO DE GREGORIO CONCHA3