MUNITA SEPULVEDA, JOSE MANUEL

Preferred name

Main Affiliation

Facultad de Medicina Clínica Alemana Universidad del Desarrollo

josemunita@udd.cl

ORCID

0000-0002-7870-1056

Scopus Author ID

24825037700

Goggle Scholar

https://scholar.google.com/citations?user=y3s1KhIAAAAJ&hl=es&oi=ao

Now showing 1 - 10 of 139

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Dataset - Geographic divergence of methicillin-resistant Staphylococcus aureus ST5-SCCmecI in the aftermath of a major earthquake and tsunami: impact of a plasmid harboring heavy metal resistance genes
(United States National Library of Medicine, 2025)
MARTINEZ SOLIS, JOSE RODRIGO WALDEMAR
;
DIAZ ORTIZ, SANDRA LORENA
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QUESILLE VILLALOBOS, ANA MARIA
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ROBERTO ANDRES RIQUELME NEIRA
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RIVAS JIMENEZ, LINA MARIA
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Dataset - Molecular mechanisms leading to ceftolozane/tazobactam resistance in clinical isolates of Pseudomonas aeruginosa from five Latin American countries
(National Library of Medicine, 2022)
MUNITA SEPULVEDA, JOSE MANUEL
;
JOSE RODRIGO WALDEMAR MARTINEZ SOLIS
9
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Dataset - Dynamics of the MRSA Population in a Chilean Hospital: a Phylogenomic Analysis (2000-2016)
(2023)
MARTINEZ SOLIS, JOSE RODRIGO WALDEMAR
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SPENCER SANDINO, MARÍA DE LOS ÁNGELES
;
RIVAS JIMENEZ, LINA MARIA
;
DIAZ ORTIZ, SANDRA
;
QUESILLE VILLALOBOS, ANA MARIA
5
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Dataset - Cost-effectiveness of screening, decolonisation and isolation strategies for carbapenem-resistant Enterobacterales and methicillin-resistant Staphylococcus aureus infections in hospitals: a sex-stratified mathematical modelling study
(GITHub, 2025)
PETERS, ANNE SOPHIE
;
MUNITA SEPULVEDA, JOSE MANUEL
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<i>In Vivo</i> Resistance to Ceftolozane/Tazobactam in <i>Pseudomonas aeruginosa</i> Arising by AmpC- and Non-AmpC-Mediated Pathways
(2018)
Erik Skoglund
;
Henrietta Abodakpi
;
Rafael Rios
;
Lorena Diaz
;
Elsa De La Cadena
<jats:p>Two pairs of ceftolozane/tazobactam susceptible/resistant <jats:italic>P. aeruginosa</jats:italic> were isolated from 2 patients after exposure to <jats:italic>β</jats:italic>-lactams. The genetic basis of ceftolozane/tazobactam resistance was evaluated, and <jats:italic>β</jats:italic>-lactam-resistant mechanisms were assessed by phenotypic assays. Whole genome sequencing identified mutations in AmpC including the mutation (V213A) and a deletion of 7 amino acids (P210–G216) in the Ω-loop. Phenotypic assays showed that ceftolozane/tazobactam resistance in the strain with AmpC<jats:sub>V213A</jats:sub> variant was associated with increased <jats:italic>β</jats:italic>-lactamase hydrolysis activity. On the other hand, the deletion of 7 amino acids in the Ω-loop of AmpC did not display enhanced <jats:italic>β</jats:italic>-lactamase activity. Resistance to ceftolozane/tazobactam in <jats:italic>P. aeruginosa</jats:italic> is associated with changes in AmpC; however, the apparent loss of <jats:italic>β</jats:italic>-lactamase activity in AmpC∆7 suggests that non-AmpC mechanisms could play an important role in resistance to <jats:italic>β</jats:italic>-lactam/<jats:italic>β</jats:italic>-lactamase inhibitor combinations.</jats:p>
4
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Clinical and Genomic Characterization of Recalcitrant Enterococcal Bacteremia: A Multicenter Prospective Cohort Study (VENOUS)
(Oxford University Press (OUP), 2025-07-08)
Shelby R Simar
;
Truc T Tran
;
Kirsten B Rydell
;
Rachel L Atterstrom
;
Pranoti V Sahasrabhojane
Background: Patients with recalcitrant enterococcal bloodstream infections are at greater risk of adverse outcomes. We identified patients in the 2016-2022 Vancomycin-Resistant Enterococcal Bacteremia Outcomes Study (VENOUS) cohort experiencing recalcitrant bloodstream infections for further clinical and genomic characterization. Methods: Bacteremia episodes were considered "persistent" if there was a lack of clearance on day four while receiving >= 48 hours of active therapy and recurrent if there was clearance during hospitalization with a subsequent positive culture (collectively, "recalcitrant" bacteremia). A matched comparison group of non-recalcitrant bacteremia patients was chosen in a 2:1 control:case ratio. Isolates were subjected to short- and long-read whole-genome sequencing. Hybrid assemblies were created using a custom pipeline. Findings: A total of 46 recalcitrant infections from 41 patients were identified. Patients with persistent bacteremia were more often admitted to the ICU upon admission relative to controls. E. faecalis strains causing persistent infections had a significantly higher proportion of genes associated with carbohydrate utilization relative to controls. Representation of functional groups associated with mutated genes was disparate between E. faecium and E. faecalis index and persistent isolates, suggesting species-specific adaptation. Discussion: Enterococcal isolates causing recalcitrant bacteremia were genomically diverse, indicating that strain-specific signatures are not drivers of persistence. However, comparisons of index vs. persistent isolates revealed that E. faecium may be genetically pre-adapted to cause persistent infection, and site-specific structural variation during infection suggests the role of differential gene expression in adaptation and persistence. This data lays groundwork for future studies to define signatures of enterococcal adaptation during bacteremia.
2Scopus© Citations 3
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Daptomycin and Quinupristin-Dalfopristin
(2019)
MUNITA SEPULVEDA, JOSE MANUEL
2
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DO INTERNATIONAL MIGRANTS FACE HIGHER BACTERIAL DRUG RESISTANCE COMPARED TO NATIVES? A SYSTEMATIC REVIEW
(2019)
CABIESES VALDES, BALTICA BEATRIZ
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MUNITA SEPULVEDA, JOSE MANUEL
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Anne Peters
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Acuna, M. P
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Norman Uphoff
7
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Cost-effectiveness of screening, decolonisation and isolation strategies for carbapenem-resistant Enterobacterales and methicillin-resistant Staphylococcus aureus infections in hospitals: a sex-stratified mathematical modelling study
(Elsevier BV, 2025-03)
Kasim Allel
;
Patricia Garcia
;
Anne Peters
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MUNITA SEPULVEDA, JOSE MANUEL
;
Eduardo A. Undurraga
2
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Antimicrobial resistance in wildlife and in the built environment in a wildlife rehabilitation center
(2021)
Carla Baros Jorquera
;
Andrea I. Moreno-Switt
;
Nicole Sallaberry-Pincheira
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MUNITA SEPULVEDA, JOSE MANUEL
;
Camila Flores Navarro
4Scopus© Citations 48

MUNITA SEPULVEDA, JOSE MANUEL

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