MATURANA PEREA, ANDRES

Preferred name
MATURANA PEREA, ANDRES
Main Affiliation
Email
amaturana@udd.cl
ORCID
0000-0002-9219-9146
Scopus Author ID
57205356806

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    Scopus© Citations 3  1
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    Economic evaluation of HIV screening in pregnant women attending antenatal clinics in India
    (2006-07-01)
    Kumar, Manoj
    ;
    Birch, Stephen
    ;
    MATURANA PEREA, ANDRES  
    ;
    Gafni, Amiran
    Objective: With prevalence of HIV rising in pregnant women in India, pediatric HIV/AIDS is emerging as a public health problem. We evaluated the additional costs to the health care system and the additional health outcomes of introducing a voluntary primary care HIV screening program for pregnant women in India. Methods: The analysis was conducted from the government perspective. We analyzed two scenarios: a programme of universal screening nation-wide and a programme of screening restricted to high prevalence states. Health benefits were measured by the number of perinatal HIV cases prevented and the reduction in the potential years of life lost (PYLL). Findings: Nation-wide screening would cost the government Rs. 254.78 million and would prevent 9880 cases of perinatal HIV resulting in savings of 131,700 life years (average cost per HIV case prevented Rs. 25,787; per year reduction in PYLLs Rs. 1935). Implementing the program in only the high prevalence states would achieve 45% of these reductions in cases and life years lost at only 20% of this cost, at an average of Rs. 12,091 per HIV case prevented or Rs. 907 per year reduction in PYLLs (44 Indian rupees = US$ 1). In sensitivity analysis, the cost of the program was influenced mainly by antenatal coverage, the cost of the HIV test, the lifetime costs of treatment of a HIV infected child and the overhead costs. Conclusions: We provide an estimate of the additional costs and health effects of two approaches to introducing HIV screening among pregnant women in India. Decision-makers would have to demonstrate that the resources used for its implementation would result in more health benefits than from the alternative uses of those resources. © 2005 Elsevier Ireland Ltd. All rights reserved.
      8Scopus© Citations 12
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    Prevalence of Cow’s Milk Allergy in Infants from an Urban, Low-Income Population in Chile: A Cohort Study
    (MDPI AG, 2025-05-29)
    Sylvia Cruchet
    ;
    MarĂ­a Eugenia Arancibia
    ;
    MATURANA PEREA, ANDRES  
    ;
    Pamela Marchant
    ;
    Lorena RodrĂ­guez
    Background. Cow’s milk allergy (CMA) is one of the most common food allergies in infancy, with prevalence estimates of 0.5–7.5% in high-income countries. Data from low- and middle-income regions remain limited, and the predominant immune mechanism (IgE or non-IgE mediated) may vary across populations. Objective. We aimed to determine the prevalence and clinical characteristics of CMA in infants from an urban, low-income Chilean population. Methods. A prospective cohort study was conducted at Padre Hurtado Hospital in Santiago, Chile. Healthy term newborns were recruited and followed for up to 12 months. Sociodemographic, perinatal data and parental atopy were recorded. Parents were contacted monthly to screen for CMA symptoms. Infants with ≥two symptoms underwent clinical evaluation, a 4-week cow’s milk protein exclusion diet, and an open oral food challenge (OFC). Diagnosis followed international consensus guidelines. Results. Of 552 enrolled infants (48% male), 27 were diagnosed with CMA, yielding a prevalence of 4.9% (95% CI 3.1–7.0%). All cases exhibited non-IgE-mediated symptoms, including vomiting, dermatitis, colic, and perianal erythema. CMA was diagnosed before 6 months of age in 74% of cases. At 12 months, 40% had developed oral tolerance. Sociodemographic and perinatal characteristics were similar between groups, but some self-reported parental atopic traits were more frequent in CMA cases. Conclusions. CMA prevalence in this Chilean cohort was comparable to that reported in high-income countries, with a predominance of non-IgE-mediated forms. These findings support the need for standardized diagnostic protocols, including OFC, in diverse populations. Future studies should explore long-term outcomes and risk factors in non-IgE-mediated CMA.</jats:p>
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    Profesionalismo y auto cuidado de los residentes, ÂżcĂłmo debemos enfocar su formaciĂłn?
    (2021)
    Carla Benaglio
    ;
    MATURANA PEREA, ANDRES  
    ;
    Luigina Mortari
    ;
    Arnoldo Riquelme
    <jats:p>El profesionalismo es una competencia bien definida en la educación de los residentes, sin embargo, es un constructo complejo, sensible a variables sociales y culturales. Puede definirse como el nivel de destreza, buen juicio y comportamiento adecuado esperable de personas entrenadas para realizar bien su trabajo. Es una competencia que no se mantiene estable en el tiempo y decae cuando el profesional está sometido a altos niveles de estrés y se asocia a calidad de cuidado, educación, ética, moral, filosofía y humanismo. Es una competencia esencial en el profesional por lo cual debemos replantear los currículos para incluir formas de enseñar y evaluar el profesionalismo. Es fundamental pensar en programas que logren equilibrar la carga de trabajo con el bienestar de los futuros profesionales. Debemos generar un clima adecuado de aprendizaje donde el profesional en entrenamiento sea un protagonista activo, y el auto cuidado sea visibilizado como una competencia esencial para mantener el equilibrio entre la vida personal y profesional. Este articulo plantea una revisión y reflexión de este tema que cobra cada vez mas importancia en la formación de postgrado de futuros especialistas.</jats:p>
      22Scopus© Citations 1
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    Association of Cow's Milk Protein Allergy Prevalence With Socioeconomic Status in a Cohort of Chilean Infants
    (2020)
    MarĂ­a E. Arancibia
    ;
    LUCERO, YALDA  
    ;
    Isabel Miquel
    ;
    Pamela Marchant
    ;
    Lorena Rodriguez
      7  1Scopus© Citations 18
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    Prevalencia de patología oftalmológica en prematuros menores de un año de edad
    (2012)
    Juan Pablo LĂłpez G
    ;
    Diego OsandĂłn V
    ;
    Oliver Denk V
    ;
    Ricardo Stevenon A
    ;
    Ricardo Agurto R
    Scopus© Citations 1  1
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    Interactive Guidance Intervention to Address Sustained Social Withdrawal in Preterm Infants in Chile: Protocol for a Randomized Controlled Trial
    (2020)
    Jorge Bustamante Loyola
    ;
    Marcela Perez Retamal
    ;
    Monica Isabel Morgues Nudman
    ;
    MATURANA PEREA, ANDRES  
    ;
    Ricardo Salinas Gonzalez
    <jats:sec> <jats:title>Background</jats:title> <jats:p>Preterm newborns can be exposed early to significant perinatal stress, and this stress can increase the risk of altered socioemotional development. Sustained social withdrawal in infants is an early indicator of emotional distress which is expressed by low reactivity to the environment, and if persistent, is frequently associated with altered psychological development. Infants born prematurely have a higher probability of developing sustained social withdrawal (adjusted odds ratio 1.84, 95% CI 1.04-3.26) than infants born full term, and there is a correlation between weight at birth and sustained social withdrawal at 12 months of age.</jats:p> </jats:sec> <jats:sec> <jats:title>Objective</jats:title> <jats:p>The aims of this study are to compare the effect of the interactive guidance intervention to that of routine pediatric care on sustained social withdrawal in infants born moderately or late preterm and to explore the relationship between sustained social withdrawal in these infants and factors such as neonatal intensive care unit hospitalization variables, parental depression, and posttraumatic stress symptoms.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>This study is designed as a multicenter randomized controlled trial. Moderate and late preterm newborns and their parents were recruited and randomized (1:1 allocation ratio) to control and experimental groups. During neonatal intensive care unit hospitalization, daily duration of skin-to-skin contact, breastfeeding, and parental visits were recorded. Also, a daily score for neonatal pain and painful invasive procedures were recorded. After discharge from neonatal intensive care, for the duration of the study, both groups will attend follow-up consultations with neonatologists at 2, 6, and 12 months of age (corrected for gestational age) and will receive routine pediatric care. Every consultation will be recorded and assessed with the Alarm Distress Baby Scale to detect sustained social withdrawal (indicated by a score of 5 or higher). The neonatologists will perform an interactive guidance intervention if an infant in the intervention group exhibits sustained social withdrawal. In each follow-up consultation, parents will fill out the Edinburgh Postnatal Depression Scale, the modified Perinatal Posttraumatic Stress Disorder Questionnaire, and the Impact of Event Scale–revised.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Recruitment for this trial started in September 2017. As of May 2020, we have completed enrollment (N=110 infants born moderately or late preterm). We aim to publish the results by mid-2021.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>This is the first randomized controlled trial with a sample of infants born moderately or late preterm infants who will attend pediatric follow-up consultations during their first year (corrected for gestational age at birth) with neonatologists trained in the Alarm Distress Baby Scale and who will receive this interactive guidance intervention. If successful, this early intervention will show significant potential to be implemented in both public and private health care, given its low cost of training staff and that the intervention takes place during routine pediatric follow-up.</jats:p> </jats:sec> <jats:sec> <jats:title>Trial Registration</jats:title> <jats:p>ClinicalTrials.gov NCT03212547; https://clinicaltrials.gov/ct2/show/NCT03212547.</jats:p> </jats:sec> <jats:sec> <jats:title>International Registered Report Identifier (IRRID)</jats:title> <jats:p>DERR1-10.2196/17943</jats:p> </jats:sec>
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    Animal-Derived Surfactants Versus Past and Current Synthetic Surfactants: Current Status
    (2007-03-01)
    Moya, Fernando
    ;
    MATURANA PEREA, ANDRES  
    In this review, the authors assess major outcomes resulting from head-to-head comparison trials of animal-derived surfactants with previous and newer synthetic surfactants and among them. They also pay special attention to issues of study design and quality of the trials reviewed. Animal-derived surfactants that contain surfactant proteins (Survanta, Infasurf, and Curosurf) perform clinically better than Exosurf, a synthetic surfactant containing only phospholipids, primarily in outcomes related to acute management of respiratory distress syndrome (RDS; faster weaning and pneumothorax) but not in overall mortality or incidence of bronchopulmonary dysplasia (BPD). Trials comparing various animal-derived surfactants that provide different amounts of surface protein B (SP-B) or phospholipids have shown minor differences in outcomes related to the management of RDS or none at all. The exception is the suggestion of better survival using a high initial dose of Curosurf when compared with Survanta. This observation is based on analysis of trials of relatively lesser quality that have included a smaller number of infants than other surfactant comparisons, however. Data from recent trials comparing a new-generation synthetic surfactant that contains a peptide mimicking the action of SP-B, Surfaxin, have shown that it performs better than Exosurf (faster weaning and less BPD) and at least as well as the animal-derived surfactants Survanta and Curosurf. The ideal surfactant comparison trial to demonstrate which surfactant is better has yet to be conducted. Future surfactant comparison trials should pay particular attention to study design, be appropriately sized, and include long-term follow-up. © 2007 Elsevier Inc. All rights reserved.
      6Scopus© Citations 41