ASENJO LOBOS, CLAUDIA ANDREA DEL CARMEN
Preferred name
ASENJO LOBOS, CLAUDIA ANDREA DEL CARMEN
Main Affiliation
ORCID
0000-0002-8264-0524
Scopus Author ID
36645608300
10 results
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Item type:Publication, Stroke in Latin America: A systematic review of the incidence, prevalence and case-fatality between 1997-2021(2022); ;DELFINO, CARLOS; ;GONZÁLEZ MC CAWLEY, FRANCISCAAmy Riviotta6 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Dynamic Limonene Breath Testing Maximizes Classification Performance for Subjects With Cirrhosis(2023) ;GINESTA, ALEXANDRA ;CONTRERAS BASULTO, JORGE; ;Luis Mendez AlcamanAmy Riviotta3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Exogenous Volatile Organic Compound (EVOC®) Breath Testing Maximizes Classification Performance for Subjects with Cirrhosis and Reveals Signs of Portal Hypertension(2023) ;Giuseppe Ferrandino ;Federico Ricciardi ;Antonio Murgia ;Iris BandaMenisha Manhota<jats:p>Background: Cirrhosis detection in primary care relies on low-performing biomarkers. Consequently, up to 75% of subjects with cirrhosis receive their first diagnosis with decompensation when causal treatments are less effective at preserving liver function. We investigated an unprecedented approach to cirrhosis detection based on dynamic breath testing. Methods: We enrolled 29 subjects with cirrhosis (Child–Pugh A and B), and 29 controls. All subjects fasted overnight. Breath samples were taken using Breath Biopsy® before and at different time points after the administration of 100 mg limonene. Absolute limonene breath levels were measured using gas chromatography–mass spectrometry. Results: All subjects showed a >100-fold limonene spike in breath after administration compared to baseline. Limonene breath kinetics showed first-order decay in >90% of the participants, with higher bioavailability in the cirrhosis group. At the Youden index, baseline limonene levels showed classification performance with an area under the roc curve (AUROC) of 0.83 ± 0.012, sensitivity of 0.66 ± 0.09, and specificity of 0.83 ± 0.07. The best performing timepoint post-administration was 60 min, with an AUROC of 0.91, sensitivity of 0.83 ± 0.07, and specificity of 0.9 ± 0.06. In the cirrhosis group, limonene bioavailability showed a correlation with MELD and fibrosis indicators, and was associated with signs of portal hypertension. Conclusions: Dynamic limonene breath testing enhances diagnostic performance for cirrhosis compared to static testing. The correlation with disease severity suggests potential for monitoring therapeutic interventions. Given the non-invasive nature of breath collection, a dynamic limonene breath test could be implemented in primary care.</jats:p>Scopus© Citations 5 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Targeted breath biopsy® profiling of induced biomarkers unveils a metabolic adaptation in cirrhosis toward alcohol production(2024) ;GINESTA FRINGS, CARMEN ;CONTRERAS MARTÍNEZ, JORGE ;MENDEZ DEDES, LUIS; Francisca Bascur1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Factores pronósticos que influyen en los resultados de tratamiento de la periimplantitis: Una revisión sistemática.(2023) ;Camila Sánchez; Jorge Jofré2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, S2053 Targeted Breath Biopsy Profiling of Induced Biomarkers Unveils a Metabolic Adaptation in Cirrhosis Toward Alcohol Production(2024) ;Giuseppe Ferrandino ;Federico Ricciardi ;Antonio Murgia ;Menisha ManhotaDaniela Fonseca1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Treatments for non-small cell lung cancer: a systematic quality assessment of clinical practice guidelines(2023) ;Marcela Cortés-Jofré ;Meisser Madera ;Lesbia Tirado-Amador; Xavier Bonfill-Cosp4Scopus© Citations 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Factores pronósticos que influyen en los resultados de tratamiento de la periimplantitis: Una revisión sistemática.(2023) ;Camila Sánchez; Jorge Jofré2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Disparities in Stroke Incidence Over Time by Sex and Age in Latin America and the Caribbean Region 1997 to 2021: A Systematic Review and Meta‐Analysis(2023) ;Marilaura Nuñez ;Carlos Delfino; ; <jats:sec sec-type="background" xml:lang="en"> <jats:title>Background</jats:title> <jats:p xml:lang="en">High‐income country studies show unfavorable trends in stroke incidence (SI) in younger populations. We aimed to estimate temporal change in SI disaggregated by age and sex in Latin America and the Caribbean region.</jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Methods and Results</jats:title> <jats:p xml:lang="en"> A search strategy was used in MEDLINE, WOS, and LILACS databases from 1997 to 2021, including prospective population‐based observational studies with first‐ever stroke incidence in Latin America. Reports without data broken down by age and sex were excluded. Risk of bias was assessed with The Joanna Briggs Institute's guide. The main outcomes were incidence rate ratio and relative temporal trend ratio of SI, comparing time periods before 2010 with after 2010. Pooled relative temporal trend ratios considering only studies with 2 periods in the same population were calculated by random‐effects meta‐analysis. Meta‐regression analysis was used to evaluate incidence rate determinants. From 9242 records identified, 6 studies were selected including 4483 first‐ever stroke in 4 101 084 individuals. Crude incidence rate ratio in younger subjects (<55 years) comparing before 2010:after 2010 periods showed an increase in SI in the past decade (incidence rate ratio, 1.37 [95% CI, 1.23–1.50]), in contrast to a decrease in older people during the same period (incidence rate ratio, 0.83 [95% CI, 0.76–0.89]). Overall relative temporal trend ratio (<55:≥55 years) was 1.65 (95 CI%, 1.50–1.80), with higher increase in young women (pooled relative temporal trend ratio, 3.08 [95% CI, 1.18–4.97]; <jats:italic>P</jats:italic> for heterogeneity <0.001). </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Conclusions</jats:title> <jats:p xml:lang="en">An unfavorable change in SI in young people, especially in women, was detected in population‐based studies in the past decade in Latin America and the Caribbean. Further investigation of the explanatory variables is required to ameliorate stroke prevention and inform local decision‐makers.</jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Registration</jats:title> <jats:p xml:lang="en"> URL: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/prospero/">https://www.crd.york.ac.uk/prospero/</jats:ext-link> Identifier: CRD42022332563. </jats:p> </jats:sec>7Scopus© Citations 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Cardiovascular events risk in patients with systemic autoimmune diseases: a prognostic systematic review and meta-analysis(2023); ;Leticia González ;Juan Francisco Bulnes ;Marta RoqueScopus© Citations 21 1