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    The effect of computer prompt in breaks of sedentary behaviour among office workers: a systematic review and meta-analysis
    (Springer Science and Business Media LLC, 2025-06-13)
    LEPPE ZAMORA, JAIME ESTEBAN  
    ;
    Sara Ramos-Fuster
    ;
    Barbara Muñoz-Monari
    ;
    Sonia Roa-Alcaino
    ;
    Olga Lucía Sarmiento
    Background Prolonged sitting time in the workplace constitutes a significant portion of waking hours. Sedentary behaviour is associated with higher risks of cardiovascular diseases, obesity, and all-cause mortality. Interventions to reduce workplace sitting, such as health apps, height-adjustable desks, and active breaks, have shown relative effectiveness in improving health outcomes. Among these, computer prompt interventions represent a simple and scalable strategy that can remind workers to take breaks and reduce sedentary behaviour. This study evaluates the effectiveness of computer prompt interventions to reduce sitting at work compared to no intervention or combined strategies. Methods Primary studies were searched in PubMed (MEDLINE), EMBASE, Scopus, and CENTRAL of the Cochrane Library. The search was conducted until December 2024. Keywords included terms like “sedentary behaviour,” “computer prompts,” “sitting time,” and “office workers.” Only randomized controlled trials (individual or cluster) involving desk-based workers aged 18 or older that evaluated computer prompt software were included. Risk of bias was assessed using the Cochrane Risk-of-Bias tool (RoB2). Mean differences with 95% confidence intervals (CI) were calculated for sitting time and secondary outcomes. Analyses were performed using RevMan and R software, and GRADE methodology was applied to assess the certainty of evidence. Results From 17,880 records, 18 studies involving 1164 office workers were included in the analysis. Ten studies focused exclusively on computer prompts, while 8 studies implemented combined strategies (e.g., computer prompts plus sit-to-stand desks). The median intervention length was 8 weeks, ranging from one to 24 weeks. Studies using only computer prompts included breaks lasting from 1 to 10 min every 30 min up to an hour. Combined strategies included breaks from 6 to 30 min every 30 min up to 3 h. According to objective measurements, the meta-analysis showed a significant reduction of 12.46 min/workday in sitting time (95% CI: -18.12, -6.80) and a significant increase of 1029.99 steps/workday (95% CI: 815.97, 1244). Secondary outcomes included work-related, musculoskeletal, and cardiometabolic outcomes favouring computer prompts but not statistically significant. The certainty of evidence for primary outcomes is rated low to moderate according to GRADE. Conclusions Computer prompt software interventions show effectiveness in reducing sitting time among office workers. However, more long-term prospective studies with larger sample sizes are needed to accurately determine the effectiveness of computer prompts on various work- and health-related outcomes.
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    Latin-American guidelines for opioid use in chronic nononcologic pain
    (2017)
    Argelia Lara-Solares
    ;
    Carlos Aguayo Zamora
    ;
    César Amescua García
    ;
    João Batista Santos Garcia
    ;
    María del Rosario Berenguel Cook
    <jats:p>Aim: Latin-American experts in the use of opioids in patients with chronic nononcologic pain (CNOP) have updated existing recommendations to current Latin-American reality. Methods: Several key opinion leaders from Latin America participated in a face-to-face meeting in Guatemala (April 2015) to discuss the use of opioids in CNOP. Subgroups of experts worked on specific topics, reviewed the literature and shaped the final manuscript. Results: The expert panel developed guidelines taking into consideration the utility of both opioid and nonopioid analgesics and factors pertaining to their efficacy, safety, adherence, administration and risks for abuse/addiction. Conclusion: Latin-American guidelines for the use of opioids in CNOP should improve pain relief and patients’ quality of life by increasing access to these effective agents.</jats:p>
      3Scopus© Citations 18
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    Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke
    (2017)
    Craig S. Anderson
    ;
    Hisatomi Arima
    ;
    LAVADOS GERMAIN, PABLO MANUEL  
    ;
    Laurent Billot
    ;
    Maree L. Hackett
      7Scopus© Citations 166
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    Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage
    (2013)
    Craig S. Anderson
    ;
    Emma Heeley
    ;
    Yining Huang
    ;
    Jiguang Wang
    ;
    Christian Stapf
    Scopus© Citations 1333  1
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    Treatments for non-small cell lung cancer: a systematic quality assessment of clinical practice guidelines
    (2023)
    Marcela Cortés-Jofré
    ;
    Meisser Madera
    ;
    Lesbia Tirado-Amador
    ;
    Claudia Asenjo-Lobos  
    ;
    Xavier Bonfill-Cosp
      4Scopus© Citations 3
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    Regarding Comparison of Recent Practice Guidelines for the Management of Patients with Asymptomatic Carotid Stenosis
    (2022)
    Anne L. Abbott
    ;
    BRUNSER, ALEJANDRO  
    ;
    Oliseneku D. Uyagu
    ;
    Hrvoje Budincevic
    ;
    Konstantinos Spanos
      6Scopus© Citations 1
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      8Scopus© Citations 185
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    Temporal Trends of Intravenous Thrombolysis Utilization in Acute Ischemic Stroke in a Prospective Cohort From 1998 to 2019: Modeling Based on Joinpoint Regression
    (2022)
    Verónica V. Olavarría  
    ;
    HOFFMEISTER ARCE, LORENA  
    ;
    Carolina Vidal
    ;
    BRUNSER, ALEJANDRO  
    ;
    HOPPE WIEGERING, ARNOLD JOHANNES GOTTLIEB  
    <jats:sec><jats:title>Introduction</jats:title><jats:p>The frequency of intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) is lower than it should be in several regions of the world. It is unclear what interventions can produce significant improvements in IVT utilization. We aimed to investigate the temporal trends in IVT in AIS and identify changes in time that could be associated with specific interventions.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We included patients with AIS who were admitted from January 1998 to December 2019 in our institution. To analyze trends in utilization and time points in which they changed, we performed a Joinpoint regression analysis. Interventions were assigned to a specific category according to the Behavior Change Wheel framework intervention function criteria.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 3,361 patients with AIS were admitted, among which 538 (16%) received IVT. There were 245 (45.5%) women, and the mean age and median National Institutes of Health Stroke Scale (NIHSS) scores were 68.5 (17.2) years and 8 (interquartile range, 4–15), respectively. Thrombolysis use significantly increased by an average annual 7.6% (95% CI, 5.1–10.2), with one Joinpoint in 2007. The annual percent changes were.45% from 1998 to 2007 and 9.57% from 2007 to 2019, concurring with the stroke code organization, the definition of door-to-needle times as an institutional performance measure quality indicator, and the extension of the therapeutic window.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The IVT rates consistently increased due to a continuous process of protocol changes and multiple interventions. The implementation of a complex multidisciplinary intervention such as the stroke code, as well as the definition of a hospital quality control metric, were associated with a significant change in this trend.</jats:p></jats:sec>
      1Scopus© Citations 10
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    Breaking Down Barriers: Easter Island's First Telestroke Thrombolysis Experience and Case Report
    (2022)
    E. Mazzon
    ;
    C. Delfino
    ;
    S. Mirelis
    ;
    M. Arévalo
    ;
    D. Rojas
      21
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    Prevalence of chronic pulmonary aspergillosis regarding time of tuberculosis diagnosis in Brazil
    (2022)
    Cláudia E. Volpe‐Chaves
    ;
    James Venturini
    ;
    Suse B. Castilho
    ;
    Simone S. O. Fonseca
    ;
    Thiago F. Nunes
      25Scopus© Citations 14