Temporal Trends of Intravenous Thrombolysis Utilization in Acute Ischemic Stroke in a Prospective Cohort From 1998 to 2019: Modeling Based on Joinpoint Regression
Journal
Frontiers in Neurology
ISSN
1664-2295
Date Issued
2022
Author(s)
Carolina Vidal
Pablo M. Lavados
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:sec><jats:title>Introduction</jats:title><jats:p>The frequency of intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) is lower than it should be in several regions of the world. It is unclear what interventions can produce significant improvements in IVT utilization. We aimed to investigate the temporal trends in IVT in AIS and identify changes in time that could be associated with specific interventions.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We included patients with AIS who were admitted from January 1998 to December 2019 in our institution. To analyze trends in utilization and time points in which they changed, we performed a Joinpoint regression analysis. Interventions were assigned to a specific category according to the Behavior Change Wheel framework intervention function criteria.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 3,361 patients with AIS were admitted, among which 538 (16%) received IVT. There were 245 (45.5%) women, and the mean age and median National Institutes of Health Stroke Scale (NIHSS) scores were 68.5 (17.2) years and 8 (interquartile range, 4–15), respectively. Thrombolysis use significantly increased by an average annual 7.6% (95% CI, 5.1–10.2), with one Joinpoint in 2007. The annual percent changes were.45% from 1998 to 2007 and 9.57% from 2007 to 2019, concurring with the stroke code organization, the definition of door-to-needle times as an institutional performance measure quality indicator, and the extension of the therapeutic window.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The IVT rates consistently increased due to a continuous process of protocol changes and multiple interventions. The implementation of a complex multidisciplinary intervention such as the stroke code, as well as the definition of a hospital quality control metric, were associated with a significant change in this trend.</jats:p></jats:sec>
Subjects
health-care professionals
;
to-needle times
;
controlled-trial
;
guidelines
;
impact
;
rates
;
door
;
management
;
increase
;
acute ischemic stroke
;
aged
;
article
;
atrial fibrillation
;
blood clot lysis
;
cerebrovascular accident
;
cohort analysis
;
computer assisted tomography
;
continuous process
;
controlled study
;
diabetes mellitus
;
diastolic blood pressure
;
female
;
glucose blood level
;
human
;
hypertension
;
major clinical study
;
male
;
national institutes of health stroke scale
;
prospective study
;
quality control
;
systolic blood pressure
;
total quality management