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Early developmental screening tools constructed in Latin American countries: umbrella review
(Publicidad Permanyer, SLU, 2025-04-09)
SCHONHAUT BERMAN, LUISA
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Antonia Valdés
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Ilan Oppenheimer
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Antonio Rizzoli-Córdoba
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Rolando Rivera
2Scopus© Citations 2
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Arsenic Exposure During Pregnancy and Childhood: Factors Explaining Changes over a Decade
(MDPI AG, 2025-03-16)
RUBILAR RAMIREZ, PAOLA ANDREA
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HIRMAS ADAUY, MACARENA SOLEDAD
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APABLAZA SALINAS, MAURICIO IVÁN
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Camila Awad
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Xaviera Molina
Arsenic chronic exposure, particularly in its inorganic form, represents a significant public health concern. This study was conducted in Arica, the northernmost city in the country, whose inhabitants have been exposed to inorganic arsenic both naturally through drinking water and anthropogenically due to a toxic waste disposal site. We explored changes in inorganic arsenic levels in a cohort of pregnant women and their children over a decade, identifying exposure trends and their determinants. We used data on arsenic exposure through maternal urine samples during pregnancy, collected by the Health Authority between 2013 and 2016 (measurement 1), and followed up with assessments of their children in 2023 (measurement 2). Temporal changes in inorganic arsenic concentration were analyzed using the Wilcoxon Signed-Rank test, and a mixed linear regression model was employed to determine which factors contributed to urinary inorganic arsenic levels. We did not observe significant differences in mean arsenic concentrations between the two-time points (p = 0.4026). The mixed linear regression model revealed that children consuming bottled water had 8.3% lower urinary inorganic arsenic concentrations than those drinking tap water (95% CI: −15.36 to −0.54%). Additionally, children from ethnic groups had 8.64% higher inorganic arsenic concentrations (95% CI: 0.49 to 17.5%), while those with caregivers with higher education showed a 13.67% reduction (95% CI: −25.06 to −0.56%). Despite mitigation efforts, these findings underscore the ongoing risk of inorganic arsenic exposure among vulnerable populations. They further emphasize the importance of addressing natural arsenic contamination in water and implementing targeted interventions to reduce disparities associated with socioeconomic and demographic factors.</jats:p>
Scopus© Citations 1 6
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The Prevalence of Sexual Victimization in Children and Adolescents of Indigenous and Non-Indigenous Peoples in Chile
(Informa UK Limited, 2025-02-17)
Cristián Pinto-Cortez
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Cristóbal Guerra
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Jenniffer K. Miranda
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VARELA TORRES, JORGE JAVIER
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Soledad Álvarez-Lister
4
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Technology-Based Interventions for Promoting Well-Being in Childhood and Adolescence: A Systematic Review and Meta-Analysis
(Grupo Editorial Psicofundación, 2025)
RODRIGUEZ RIVAS, MATIAS ENRIQUE
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Sara Valdebenito
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Mariavictoria Benavente
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ALFARO INZUNZA, JAIME ANDRES
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Paula Villacura
Scopus© Citations 3 1
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Recomendaciones para el uso de terapia génica y modificadora de enfermedad en niños, niñas y adolescentes con Atrofia Muscular Espinal
(Sociedad Chilena de Pediatria, 2025-02-18)
Daniela Avila-Smirnow
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Claudia Amarales Osorio
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María de los Ángeles Beytía Reyes
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Rocío Cortés Zepeda
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Ricardo Erazo Torricelli
La Atrofia Muscular Espinal (AME) es una grave enfermedad neurológica autosómica recesiva (1-2/100,000 personas). Se clasifica en tres tipos según la edad de inicio y los hitos motores alcanzados. Es causada por variantes patogénicas en el gen Survival of Motor Neuron 1 (SMN1), y modificada por el número de copias del gen SMN2. Existen tres fármacos modificadores de la historia natural de la enfermedad, aprobados por entes reguladores: nusinersen, risdiplam y onasemnogene abeparvovec.Objetivo: Establecer recomendaciones para el uso de terapia génica y modificadora de enfermedad para AME.Método: Un panel de 9 neurólogos pediátricos expertos revisó la evidencia disponible y consensuó recomendaciones para el uso de estos fármacos en pacientes con AME.Resultados: Se revisaron 21 estudios. Todos los pacientes mantuvieron el estándar de cuidado respiratorio y nutricional. Las tres terapias se asociaron a un mejor pronóstico motor, ventilatorio y sobrevida comparados con placebo o con la historia natural de la enfermedad en pacientes presintomáticos (2-3 copias de SMN2), con AME I (<6 meses y sin ventilación mecánica permanente (VMP)), AME II y III (sin VMP). No se encontraron estudios de alta calidad que demuestren la eficacia de las terapias combinadas, en etapas avanzadas de la enfermedad ni con 0-1 copia de SMN2.Conclusiones: Se recomienda el uso de los tres fármacos en pacientes presintomáticos, con AME I < 6 meses, AME II y AME III, excepto en aquellos con VMP, etapas avanzadas o 0-1 copias de SMN2. El uso de estos fármacos en pacientes que no cumplan estos criterios debe ser evaluado individualmente por expertos.
6
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Test de Aprendizaje y Desarrollo Infantil (TADI): Evidencia adicional de su validez a nivel poblacional
(Sociedad Chilena de Pediatria, 2025-02-18)
Marta Edwards
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Iván Armijo
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SCHONHAUT BERMAN, LUISA
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Marcela Pardo
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Antonia Valdés
El “Test de Aprendizaje y Desarrollo Infantil” (TADI) es una escala de tamizaje del desarrollo para niños/as de 6 a 72 meses construida en Chile.Objetivo: Determinar la validez de la primera edición de TADI muestra nivel poblacional.Metodología:Análisis psicométrico secundario de una muestra de 11.283 niños/as chilenos que participaron de la Encuesta Longitudinal de Primera Infancia (ELPI) 2012. Se evaluó validez convergente mediante el Análisis Factorial Confirmatorio (AFC), verificado mediante Análisis Factorial Exploratorio (AFE). Se consideraron variables sociales para la validez de constructo. Para la validez concurrente, sensibilidad, especificidad y correlación se tomaron como referencias las pruebas Battelle Developmental Inventory Segunda Edición (BDI-2) y el Test de Vocabulario en Imágenes Peabody (TVIP).Resultados: De los niños evaluados, 12,6% se categorizó en Retraso o Riesgo de Retraso, y 17,3% en categoría Alerta. El AFC arrojó buenos niveles de ajuste del modelo propuesto para los datos de la escala, en particular a edades mayores. El AFE reveló patrones diferentes para distintos rangos etarios. El TADI se correlacionó significativamente con los factores socioeconómicos, como la presencia de materiales de aprendizaje en el hogar, el nivel educativo del cuidador principal, el ingreso económico y la respuesta emocional de la madre. Se encontró correlación moderadamente positiva del TADI con el BDI-2 y el TVIP, con sensibilidad y especificidad cercanos a 0,70 al incluir la categoría Alerta.Conclusiones: Los adecuados valores psicométricos del TADI en una muestra poblacional ratifican su validez como instrumento de tamizaje del desarrollo de niños/as pequeños en Chile.
2
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Ambiente alimentario alrededor de establecimientos educacionales municipalizados de la ciudad de Chillán
(SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2024-12)
Jacqueline Araneda-Flores
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Álvaro Toledo
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Constanza Inzunza
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Carolina Córdova
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PINHEIRO FERNANDES, ANNA CHRISTINA
2
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The Presence of Associated Injuries in Pediatric Radial Neck Fractures: A Systematic Review of the Literature and Meta-Analysis of Pooled Individual Patient Data
(MDPI AG, 2025-02-27)
Lisette C. Langenberg
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Joyce L. Benner
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Nazira Bernal Bader
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Christiaan J. A. van Bergen
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Joost W. Colaris
<jats:p>Background: Pediatric radial neck fractures (pRNFs) can occur in isolation or in association with concomitant injuries. It is unknown whether the presence of associated injuries should influence the choice of treatment. The aim of this study is to assess the incidence of associated injuries in pRNF and their correlation with fracture angulation (Judet grade) or the patient’s age (under or over ten years of age). Methods: A systematic literature review was performed following PRISMA-IPD guidelines, including case series on pRNF with a minimum of five cases of children until 16 years of age. The quality assessment included a risk of bias analysis and evaluation using the MINORS criteria. Individual patient data on age, Judet classification and associated injuries were extracted from the included studies and pooled for the meta-analysis. The correlation between the presence of associated injury and the patient’s age or Judet classification was depicted in two forest plots. Results: A total of 20 articles published sufficient individual patient data (n = 371) on associated injuries. All but one were retrospective case series. Fifteen articles had MINORS scores of 8 or higher. The incidence of associated injuries was 33% (123 of 371 cases). Almost half of the associated injuries included an olecranon fracture (61/123). There was no correlation between Judet classification (p = 0.243) and incidence nor between patient age and the incidence of associated injuries (p = 0.694). Conclusions: Surgeons should be aware of potential associated injuries in over a third of pRNF cases, regardless of the patient’s age or fracture angulation. Deduction of the trauma mechanism may be a more useful tool for assessing the potential presence of associated injuries than the most frequently used fracture classification or the patient’s age. More research is needed regarding the requirements for enhanced diagnostic imaging, specific treatment or follow-up adaptations in children with pRNFs and associated injuries.</jats:p>
4Scopus© Citations 1
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Exploring the feasibility and effectiveness of a naturalistic family centered intervention to enhance early interactions in toddlers with Down syndrome
(Springer Science and Business Media LLC, 2025-04-09)
Ana Mendoza-García
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Andrés Aparicio
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Paulina Sofía Arango
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TENORIO DELGADO, MARCELA
This study analyses the feasibility and effectiveness of BabyMICARE, a manualised intervention programme aimed at improving the interactions between caregivers and infants and toddlers with Down syndrome. The programme’s goal is to enhance caregivers’ sensitivity and reduce directivity during early interactions, particularly during play and daily routines. A pre-test and post-test design was used with 40 dyads of infants with Down syndrome and their caregivers, who were divided into a control group (n = 20) and an intervention group (n = 20), based on baseline scores in key interaction subscales. Sessions were conducted over 10 weeks by trained psychologists. Parent-infant interaction was assessed using the MACI coding system, which measures aspects such as sensitive responsiveness, directivity and the level of reciprocity between the parent and the child. The programme showed high feasibility, with a 100% attendance rate but some rescheduling. Caregivers evaluated it positively. The intervention group demonstrated significant improvements in five of eight MACI scales, particularly in sensitive responsiveness and nondirectiveness, while no changes were observed in the control group. The results suggest that BabyMICARE is a feasible and effective intervention for promoting more responsive, less directive interactions, which may be crucial in fostering children’s development.
3
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Ethnic disparities in the association between maternal socioeconomic status and childhood anemia in Peru: a nationwide multiyear cross-sectional study
(Elsevier BV, 2025-07)
Ali Al-kassab-Córdova
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Claudio Intimayta-Escalante
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Pamela Robles-Valcarcel
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Diego Urrunaga-Pastor
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CABIESES VALDES, BALTICA BEATRIZ
1

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