Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial
Journal
The Lancet
ISSN
0140-6736
Date Issued
2025-05
Author(s)
Craig S Anderson
Debbie Summers
Menglu Ouyang
Yi Sui
Brenda Johnson
Laurent Billot
Alejandra Malavera
Roland Faigle
Paula Muñoz-Venturelli
Diana Day
Xiaoqiu Liu
Qiang Li
Lili Song
Thompson G Robinson
Francisca Urrutia-Goldsack
Michael Iacobelli
Michelle Montalbano
April Pruski
Candice Delcourt
Alice C Durham
Ahtasam Ebraimo
Ha Hong Van Ta
Pratiti Ghosh
Ann Leonhardt-Caprio
Huy Thang Nguyen
Mai Duy Ton
Stephen Jan
Hueiming Liu
Richard I Lindley
Antonio Arauz
Andrés Mercado
Wan Asyraf Wan Zaidi
Pooja Khatri
Xia Wang
Victor C Urrutia
Sheila Jala
Susan Day
Ying Hu
Aneeta Lal
Elizabeth O'Brien
Michael Devlin
Carol Bendall
Christianna Nebauer
Duncan Maddox
Melissa Brooks
Timothy Kleinig
Jennifer Cranefield
Samantha McMahon
Roy Drew
Patrick McMullan
Joschka Straha
Donna Rowley
Helen Rodgers
Jessica Pyman
Rohan Grimley
Kylie Tastula
Xiaowen (Erin) Li
Stephen Walker
Alanah Bailey
Julia R Hennessey
Ken S Butcher
Darshan Ghia
Gillian Edmonds
Erin Casey
Lydia Ting
Jane Prosser
Krystle Franklin
Henry Ma
Thanh Phan
Jason Vuong
Berzenn Urbi
Rebecca Phair
Nino Jose
Andrew Shine
Susan Lane
Juliette Mai
F O'Rourke
Christine Fuller
Ravindra Urkude
Nerida Myers
Nicole Bradford
Yi Sui
Wei Bian
Xinze Guo
Yang Zhao
Yang Zhang
Xuchen Qi
Yanxing Zhang
Huan Tang
Xuan Fang
Min Zheng
Mingzong Yan
Yanyan Yin
Penglai Shi
Junmei Li
Junming Luo
Fuqiang Fan
Xueting Guo
Huaxiang Zhou
Xueqing Ba
Yongxia Nie
Chenguang Song
Hong'an Gao
Lili Sun
Chunnan Jia
Mingyue Wang
Lihong Zhang
Jing Yang
Aijie Song
Yanli Zhang
Shuang Yu
Ying Guan
Ruyu Bai
Changqing Li
Tong Bai
Xin Li
Dongyu Wang
Haiyan Yu
Wei Zhao
Nan Li
Hongjun L
Tao Yan
Jinnan Zhang
Shumin Jiang
Yi Shen
Xiaowei Hu
Runhui Li
Li Cui
Yan Kong
Hong Zhang
Shuang Yang
Guiying Guo
Xiaochen Zhao
Haishan Zhao
Fan Zhang
Siheng Li
Yan Yang
Ying Wang
Haiyan Jin
Zijia Liu
Ping Jiang
Hongquan Jiang
Yao Shai
Ying Tang
Jing Xue
Xinyu Dong
Jinchun Wang
Jingyu Guo
Xiuying Wang
Yihe Bao
Hongyan Li
Xiangna Yang
Longna Xie
Shanshan Zhang
Xinxin Yang
Minglei Qu
Dan Deng
Jianghua Liu
Zhonglei Bao
Tieyan Wang
Li Lin
Cheng Bi
Ying Pan
Xinli Chen
Na Gao
Bo Peng
Guozhi Lu
Zidian Jiang
Yongmei Pan
Lianjing Kang
Chunxue Zhu
Lei Zhang
Yan Liang
Huiping Peng
Baiyan Song
Lilan Xiao
Jingyun Kuang
Xuejiao Lu
Xueying Liao
Zefeng Tan
Weiqi Zeng
Wanyi Lin
Enyang Zhou
Jun Wu
Yiqiao Chen
Yajun Liu
Li Meng
Zuo Wang
Yang Liu
Xuefeng Xu
Wei Xu
Yongyi Dai
Yong'e Dong
Yi'nan Zhang
Xiaodi Wang
Ying Hai
Zhi Li
Ying Pei
Guosheng Zheng
Chenyao Li
Zhifei Wang
Yundong Shi
Shanshan Li
Zhichen Liu
Jiaxin Zhang
Liying Cui
Xiaowei Zhao
Yu Qiao
Li Liu
Jingyu Zhang
Changhao Jiang
Cheng Fang
Rui Su
Chenwen Zhang
Yi Ren
Liyang Zhang
Yan Liu
Mingming Dong
Ting Yang
Sirui Gao
Rong Yin
Zhongxia Fu
Yuanming Li
Yaqin Ke
Xiaoxiao Liu
Hongguang Gao
Ying Liu
Chao Wang
Yang Liu
Bo Zhang
Zhenli Guo
Qian Tan
Wanhua Zhong
Ke Ling
Shi'e Ma
Yi Cheng
Ying Bi
Fei Jiang
Yuying Hao
Xiaoxi Yao
Zhiying Wang
Mengju Lei
Liya Lei
Dongyou Yue
Hanyan Xiao
Shuhua Chen
Yiqun Chao
Guangzhao He
Yan Li
Muhui Lin
Jiao Lv
Caixia Liu
Juan Feng
Xuedong Zhao
Xue Yang
Haiyang Yu
Ning Ma
Xuerong Lu
Runzhe Jiang
Xuemei Sun
Na Liu
Yan Zhuang
Andrés Silva-Pozo
Philippe Grandjean Silva
Nataly Cisterna Carrera
Pablo Brinck
Andrés Gallardo
Pablo Gonzalez Valdivieso
Olivia Sanhueza Neira
Astrid Haleby
Aldo Letelier Durán
Denisse Wenger
Pedro Canales
Keren Zambrano
Camila Rojas
Diego Rocha Jiménez
Mario Rivera
María Jose Orellana
Juan Polanco
Tomás Esparza
Wan Asyraf
Tan Hui Jan Tan
Rabani Remli
Wan Nur Nafisah Wan Yahya
Khoo Ching Soong
Law Zhe Kang
Siti Zaleha Sahibulddin
Dayang Anis Binti Awang Baki
Hamidah Hassan
Nur Liyana Rahmat
Nur Arifah Mohd Khaili
Rathika Rajah
Tan Juen Kiem
Abdul Hanif Khan Yusof Khan
Adnan Lutfi A. Rauf
Shi Hajjar Zakaria
Sanihah Abdul Halim
Jafri Malin Abdullah
Zamzuri Idris
Kamarul Aryffin Bin Baharuddin
Muhammad Ihfaz Ismail
Law Wan Chung
Tay Jiann Shyang
Anderson Steven
Wong Siaw Cheng
Sim Chun Yang
Sheila Ong
Judith James
Irene Looi
Antonio Arauz
Andrés Mercado-Pompa
Vanessa Cano-Nigenda
Ricardo Romero-Vucovich
Pablo Nava-Sánchez
Alejandro López-Pizano
Ranferi E. Herrera-Calderón
Fernando Góngora-Rivera
Adrian Infante-Valenzuela
Ricardo López-Soto
Raymundo Chávez-Gamboa
Luis Daniel Arreola-Sánchez
Gustavo Gonzalez Gonzalez
Sebastián León Vallejo
José Luis Galvez Romero
María Del Rocio Marquez Estudillo
Daniel Reyes Ortega
Amado Jiménez-Ruiz
José Luis Ruiz-Sandoval
Victor Aguilar-Fuentes
Juan Antonio Sotelo-Ramirez
Ricardo Gabriel Ascencio-Tene
Eric De la Cruz Estrada
Victor Mateo Perez
Duy Ton Mai
Viet Phuong Dao
Tien Dung Nguyen
Tuan Anh Le
Quoc Viet Bui
Thi Phuong Nga Nguyen
Thi Thuy Uyen Le
Thi Ngoc Nhung Tran
Thai Hoang Nguyen
Quoc Huy Nguyen
Duc Chien Vo
Trung Thanh Tran
Thai My Phuong Nguyen
Hao Nhien Cao
Linh Tuyen Nguyen
Huy Thang Nguyen
Nguyen Binh Pham
Thanh Thai An Nguyen
Quang Huy Dang
Thi Kim Anh Nguyen
Tri Thanh Vu
Tran Vinh Le
Cong Tri Le
Nguyen Mai Thao Dang
Thi Thu Trang Nguyen
Rachel Teal
Jeethu Joseph
Phil Mathieson
James Kennedy
Tim Comont
Gillian Cumberbatch
Ana Margarida Castanheira
Cai Hua Sim
Rita Ghatala
Kate Kennedy
Beatrix Sari
Jatinder Minhas
Kashif Musarrat
Shagufta Khan
Tracy Harris
Jennifer Mitchell-Douglas
Smriti Agarwal
Arshi Iqbal
Karolina Kowalska
Alex McGovern
Joel Stanton
Marilena Marinescu
Shez Feerick
Sabaa Obarey
Georgia Raingold
Katie Flanagan
Gemenelie Ann Revilla
Roberto Avila
Rose Kennedy
Yee Chin Lee
James Lyon
Alexandra Lewis
Riham El Sayed
Bianca Bandiola
Lance Vincent Sese
Kevin Babia
Zubeda Nungu
Joice Timotec
Stephanie Drysdale
Maria Consuelo Tibasia
Caroline Domingos Belo
Samantha Bayhonan Rubern
Beatrix Sari
Aaizza Naqvi
Emma Richards
Jo Howe
Chris Kamara
Sadaf Younis
Saul Sundayi
Lakshmanan Sekaran
Lisa Reid
Jimy David
Lincy Poolon
Mair A Carpenter
Balasubramanian Venkatesh
Charity W Kimaru
Courtney Greaves
Sarah E Watson
Daniel Ryan
Nichola Kearsley
Natalie Temple
Kirsty Allen
Dan Arcoria
Zoey Horne
Emelda Veraque
Junyao Zhao
Susan Evans
Alix Baird
Tomas Hannam-Penfold
Simon Smith
Camille Hutchinson
Amanda Hedstorm
Lucy Gray
Rachael Jones
Tegan Taylor
Blessing Oduh
Nasar Ahmad
Rachel Evans
Esther Erumere
Brittany Sanders
Edward Kinsella-Perks
Kevin Villa
Samantha Keenan
Sharon Finch
Rebecca Page
Lucy Topliss
Thirukumaran Duraisami
Tamsyn Pattenden
Katie Morgan
Emilie Williams
Nicola Yeo
Sonia Mariampillai
Ruth Penn
Marjorie Castillo
Nicola Cook
Susan Campbell
Shumita Palit
Helen Tench
Ronda Loosley
Tanya Sims
Rebecca Wolf-Roberts
Cerrys Parker
Senthil Kumar Subbarayan
Linda O'Brien
Victoria Riddell
Anna Smith
Cristopher Price
Mark Garside
Nina Jensen
Yaw Duodu
Cheryl Padilla-Harris
Patricia Avila Del Puerto
Bernard Esisi
Emma Clarkson
Mike Murrey
Vivek Rai
Megan Heckathorn
Heather Bartelt
Michelle Hill
Dalida Akhmedova
Brian Silver
Christina Manxhari
Tatiana Thompson
Michelle Manxhari
Ann Leonhardt-Caprio
Emily Prentiss
Curtis Benesch
Paige Hepple
Raymond Reichwein
Cesar Velasco
Andrea Singer
Erin Cekovich
Alicia Richardson
Olivia Christman
Leonard Kishel
Iftekhar Ahmed
Jana Braklow
Richard Smith
Jennifer McMahon
Carly Rossi
Alex Graves
Julie Schafer
Jamie Lynch
Sheryl Giambartolomei
Maria Aguilar
Melissa Ortiona
Elizabeth Dienst
Karin Olds
Debbie Summers
Christine Kennish
Claranne Mathiesen
Erin Conahan
Vivek Rai
Megan Heckathorn
Heather Bartelt
Michelle Hill
Dalida Akhmedova
Pramod Sethi
Sharon Biby
Amber Carter
Jessica Buckner
McNeill Kirkpatrick
Jindong Xu
Tammy Blackburn
Hannah Bell
Karen Newnam
Hannah Mack
Sarah Hocutt
Laith Altaweel
Saqib Chaudhry
Laura Madarász
Karlie Smith
Stefannie Belardo
Tugce Karageyer
Mihaela Alexander
Danielle Hagedorn
Nicole Westensee
Lisa Cohen
Teresa Wiegand
John (Hughes) Barghols
Russell Wheeler
Keri Smith
Kathy Stilwell
Victor Urrutia
Brenda Johnson
Jaime Butler
Roland Faigle
Amer AlShekhlee
Chizoba Ezepue
Bridget Gatscher
Richard King
Mike Ke
Gloria Dow
Michael Seamon
Travis Smith
Burton Tabaac
Kristen Gurnea
Jeffery Webb
Michael Phipps
Chad Schrier
Ann Leonhardt-Caprio
Emily Prentiss
Bruce Silverman
Nicole Green
Jean Kelly
Lynne Froehlich
Craig Anderson
Victor Urrutia
Brenda Johnson
Debbie Summers
Roland Faigle
Diana Day
Thompson Robinson
Pooja Khatri
Richard Lindley
Xia Wang
Yi Sui
Lili Song
Wan Asyraf
Huy Thang Nguyen
Robert Herbert
Andrew Barreto
Karen S. Rapp
Laurent Billot
Qiang Li
Xiaoqiu Liu
Yinyan Wang
Qiao Han
Menglu Ouyang
Hueiming Liu
Lizheng Xu
Stephen Jan
Rachel Tang
Michelle Montalbano
April Pruski
Diana Day
Alejandra Del Rio Weldt
Alejandro Jesus López Pizano
Siti Zaleha Sahibulddin
Nur Liyana Rahmat
Nur Afrifah Mohd Khaili
Dayang Anis
Hamidah Hassan
Ahtasam Ebraimo
Ranjit J. Injety
Alejandra Malavera
Ha Hong Van (Melanie) Ta
Pratiti Ghosh
Natalie Espinosa
Lauren Clancy
Aisling Byrne
Luke Hatchwell
Alexandra Hurden
Antonio Michell
Manuela Armenis
Ravikumar Tummapudi
Ullas Arabhavi
Menglu Ouyang
Jipeng Cheng
Zhuo Meng
Alice Durham
Ahtasam Ebraimo
Uyen Hong
Linh Le Thi My
Nguyen Nhat Ha
Thi Thao Van
Thi Kim Nhung
Tuyet Mai
Nhat Phuong Ha
Thi Huong Giang
Nhat Linh
Thi Kim Chi
Thi Nhi
Hai Ngo Thanh
Francisca Urrutia Goldsack
Alejandra Del Rio Weldt
Type
journal-article
Subjects
alteplase
;
acute ischemic stroke
;
adult
;
aged
;
article
;
controlled study
;
european quality of life 5 dimensions 5 level questionnaire
;
female
;
fibrinolytic therapy
;
human
;
intention to treat analysis
;
low intensity monitoring
;
major clinical study
;
male
;
middle aged
;
multicenter study
;
national institutes of health stroke scale
;
non-inferiority trial
;
randomized controlled trial
;
rankin scale
;
risk factor
;
sensitivity analysis
;
vital sign