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AGUILERA SANHUEZA, XIMENA PAZ
Preferred name
AGUILERA SANHUEZA, XIMENA PAZ
Main Affiliation
Email
xaguilera@udd.cl
ORCID
0000-0002-8153-6733
Scopus Author ID
6603011009
49 results
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Item type:Publication, Barriers and facilitators to antenatal care in adolescents: Results of a qualitative study in Chile(2013) ;POFFALD, LUCY; ; ;VEGA, JEANETTEJosé María González-arbesú2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 3Scopus© Citations 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Modeling the Spread of Tuberculosis in Semiclosed Communities(2013); ;BOSCH PÉREZ, PAUL JESÚS ;NÁJERA, MANUELWe address the problem of long-term dynamics of tuberculosis (TB) and latent tuberculosis (LTB) in semiclosed communities. These communities are congregate settings with the potential for sustained daily contact for weeks, months, and even years between their members. Basic examples of these communities are prisons, but certain urban/rural communities, some schools, among others could possibly fit well into this definition. These communities present a sort of ideal conditions for TB spread. In order to describe key relevant dynamics of the disease in these communities, we consider a five compartments SEIR model with five possible routes toward TB infection: primary infection after a contact with infected and infectious individuals (fast TB), endogenous reactivation after a period of latency (slow TB), relapse by natural causes after a cure, exogenous reinfection of latently infected, and exogenous reinfection of recovered individuals. We discuss the possible existence of multiple endemic equilibrium states and the role that the two types of exogenous reinfections in the long-term dynamics of the disease could play.1Scopus© Citations 17 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 18Scopus© Citations 8 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Immunization and SARS-CoV-2 Antibody Seroprevalence in a Country with High Vaccination Coverage: Lessons from Chile(2022); ;Gloria Icaza; ; <jats:p>Chile is among the most successful nations worldwide in terms of its COVID-19 vaccine rollout. By 31 December 2021, 84.1% of the population was fully vaccinated, and 56.1% received booster doses using different COVID-19 vaccines. In this context, we aimed to estimate the prevalence of anti-SARS-CoV-2 antibodies following the infection and vaccination campaign. Using a three-stage stratified sampling, we performed a population-based cross-sectional serosurvey based on a representative sample of three Chilean cities. Selected participants were blood-sampled on-site and answered a short COVID-19 and vaccination history questionnaire using Wantai SARS-CoV-2 Ab ELISA to determine seroprevalence. We recruited 2198 individuals aged 7–93 between 5 October and 25 November 2021; 2132 individuals received COVID-19 vaccinations (97%), 67 (3.1%) received one dose, 2065 (93.9%) received two doses, and 936 received the booster jab (42.6%). Antibody seroprevalence reached 97.3%, ranging from 40.9% among those not vaccinated to 99.8% in those with booster doses (OR = 674.6, 154.8–2938.5). SARS-CoV-2 antibodies were associated with vaccination, previous COVID-19 diagnosis, age group, and city of residence. In contrast, we found no significant differences in the type of vaccine used, education, nationality, or type of health insurance. We found a seroprevalence close to 100%, primarily due to the successful vaccination program, which strongly emphasizes universal access.</jats:p>6Scopus© Citations 13 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Exposure to tobacco impressions during prime-time TV
among Chilean minors by sex and socioeconomic status(2022); ; ; ;Xaviera Molina AvendañoOscar Urrejola18 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Hospitalización domiciliaria: aspectos conceptuales y su aplicación en el Hospital Padre Hurtado, Santiago de Chile. Descripción de funcionamiento y su rol durante la primera ola de la pandemia COVID-19(2022) ;María Francisca Rojas-Goldsack ;Teresita Lyng; ;Javiera HerreraJuan Pablo Leiva21Scopus© Citations 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Knowledge, attitudes, and practices regarding hantavirus disease and acceptance of a vaccine trial in rural communities of southern Chile(2017) ;Francisca Valdivieso; ;Manuel Najera ;Analia Cuiza1Scopus© Citations 15 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SARS-CoV-2 infectivity and antigenic evasion: spotlight on isolated Omicron sub-lineages(2024) ;Aldo Barrera ;Constanza Martínez-Valdebenito ;Jenniffer Angulo ;Carlos Palma<jats:p>Since the SARS-CoV-2 outbreak in 2019, a diversity of viral genomic variants has emerged and spread globally due to increased transmissibility, pathogenicity, and immune evasion. By the first trimester of 2023 in Chile, as in most countries, BQ and XBB were the predominant circulating sub-lineages of Omicron. The molecular and antigenic characteristics of these variants have been mainly determined using non-authentic spike pseudoviruses, which is often described as a limitation. Additionally, few comparative studies using isolates from recent Omicron sub-lineages have been conducted. In this study, we isolated SARS-CoV-2 variants from clinical samples, including the ancestral B.1.1, Delta, Omicron BA.1, and sub-lineages of BA.2 and BA.5. We assessed their infectivity through cell culture infections and their antibody evasion using neutralization assays. We observed variations in viral plaque size, cell morphology, and cytotoxicity upon infection in Vero E6-TMPRSS2 cells for each variant compared to the ancestral B.1.1 virus. BA.2-derived sub-variants, such as XBB.1.5, showed attenuated viral replication, while BA.5-derived variants, such as BQ.1.1, exhibited replication rates similar to the ancestral SARS-CoV-2 virus. Similar trends were observed in intestinal Caco-2 cells, except for Delta. Antibody neutralization experiments using sera from individuals infected during the first COVID-19 wave (FWI) showed a consistent but moderate reduction in neutralization against Omicron sub-lineages. Interestingly, despite being less prevalent, BQ.1.1 showed a 6.1-fold greater escape from neutralization than XBB.1.5. Neutralization patterns were similar when tested against sera from individuals vaccinated with 3xBNT162b2 (PPP) or Coronavac-Coronavac-BNT162b2 (CCP) schedules. However, CCP sera showed 2.3-fold higher neutralization against XBB.1.5 than FWI and PPP sera. This study provides new insights into the differences between BA.2 and BA.5-derived variants, leading to their eventual outcompetition. Our analysis offers important evidence regarding the balance between infectivity and antigenic escape that drives the evolution of second-generation SARS-CoV-2 variants in the population.</jats:p>5Scopus© Citations 4