VIAL CLARO, PABLO AGUSTIN

Preferred name

Main Affiliation

Facultad de Medicina Clínica Alemana Universidad del Desarrollo

pvial@udd.cl

ORCID

0000-0002-4135-0416

Scopus Author ID

17339613100, 57198245764

Goggle Scholar

https://scholar.google.com/citations?user=9xWEVqwAAAAJ&hl=es&oi=ao

Now showing 1 - 10 of 72

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Dataset - Hantavirus cardiopulmonary syndrome: organ support requirements and outcomes from a national Chilean cohort
(FONASA, 2026)
GABRIELA CONSTANZA ANDREA MEZA FUENTES
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DELGADO BECERRA, OROZIMBA IRIS
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VIAL CLARO, PABLO AGUSTIN
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LOPEZ HERNANDEZ, RENE RAMON
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Dataset - Post-COVID-19 condition: a sex-based analysis of clinical and laboratory trends
(2024)
DELFINO, CARLOS
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POLI HARLOWE, MARIA CECILIA BERTA
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VIAL COX, MARIA CECILIA
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VIAL CLARO, PABLO AGUSTIN
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RIVIOTTA, AMY LISA
3
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Covid-19 in South America: clinical and epidemiological characteristics among 381 patients during the early phase of the pandemic in Santiago, Chile
(2020)
Macarena R. Vial
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Anne Peters
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Inia Pérez
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María Spencer-Sandino
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Mario Barbé
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Understanding the characteristics of the Covid-19 pandemic in different geographical regions, ethnic and socioeconomic settings are of emerging importance. This study presents the demographic and clinical features of SARS-CoV-2 infected patients in a large private healthcare center in Santiago, Chile, during the first month of the pandemic.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>We analyzed the demographics, laboratory and clinical characteristics including severity and outcome of all patients diagnosed with Covid-19 during the first month of the pandemic. SARS-2-CoV infection was confirmed by RT-PCR in nosopharyngeal samples. The primary outcome was a composite of ICU admission or all-cause, in-hospital mortality. Clinical and laboratory parameters of hospitalized patients were analyzed regarding their association with the primary outcome.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>From March 3 to April 4, 2020, 3679 individuals were tested for SARS-CoV-2 in our hospital. Of those, 381 had Covid-19 and were included into this analysis. Most patients (99.2%) were Chileans, 12% returning from recent travel. The median age was 39 years (IQR 31–49) and 52% were female. A total of 88 patients (23.1%) were hospitalized; 18 (3.7%) required ICU and/or died. The overall mortality was 0.7%. Increased body mass index (BMI) and elevated C-reactive protein (CRP) were independently associated with ICU care or death.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>During the first weeks of the pandemic in Chile, most Covid-19 patients were young, with low rates of hospitalization, ICU requirement, and fatality. BMI and CRP on admission were predictors for severity. Our data provide important information on the clinical course and outcome of Covid-19 in a Latin American setting.</jats:p> </jats:sec>
1Scopus© Citations 15 3
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First wave of SARS-CoV-2 in Santiago Chile: Seroprevalence, asymptomatic infection and infection fatality rate
(2022)
VIAL CLARO, PABLO AGUSTIN
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GONZALEZ WIEDMAIER, CLAUDIA MARTA
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APABLAZA SALINAS, MAURICIO IVÁN
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VIAL COX, MARIA CECILIA
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Gloria Icaza
3
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Prospective Evaluation of Household Contacts of Persons with Hantavirus Cardiopulmonary Syndrome in Chile
(2007)
Marcela Ferrés
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VIAL CLARO, PABLO AGUSTIN
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Claudia Marco
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Lia Yañez
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Paula Godoy
3Scopus© Citations 149
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Immunization and SARS-CoV-2 Antibody Seroprevalence in a Country with High Vaccination Coverage: Lessons from Chile
(2022)
AGUILERA SANHUEZA, XIMENA PAZ
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Gloria Icaza
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GONZALEZ WIEDMAIER, CLAUDIA MARTA
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RUBILAR RAMIREZ, PAOLA
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APABLAZA SALINAS, MAURICIO IVÁN
<jats:p>Chile is among the most successful nations worldwide in terms of its COVID-19 vaccine rollout. By 31 December 2021, 84.1% of the population was fully vaccinated, and 56.1% received booster doses using different COVID-19 vaccines. In this context, we aimed to estimate the prevalence of anti-SARS-CoV-2 antibodies following the infection and vaccination campaign. Using a three-stage stratified sampling, we performed a population-based cross-sectional serosurvey based on a representative sample of three Chilean cities. Selected participants were blood-sampled on-site and answered a short COVID-19 and vaccination history questionnaire using Wantai SARS-CoV-2 Ab ELISA to determine seroprevalence. We recruited 2198 individuals aged 7–93 between 5 October and 25 November 2021; 2132 individuals received COVID-19 vaccinations (97%), 67 (3.1%) received one dose, 2065 (93.9%) received two doses, and 936 received the booster jab (42.6%). Antibody seroprevalence reached 97.3%, ranging from 40.9% among those not vaccinated to 99.8% in those with booster doses (OR = 674.6, 154.8–2938.5). SARS-CoV-2 antibodies were associated with vaccination, previous COVID-19 diagnosis, age group, and city of residence. In contrast, we found no significant differences in the type of vaccine used, education, nationality, or type of health insurance. We found a seroprevalence close to 100%, primarily due to the successful vaccination program, which strongly emphasizes universal access.</jats:p>
6Scopus© Citations 12
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An international, interlaboratory ring trial confirms the feasibility of an extraction-less “direct” RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples
(2022)
Margaret G. Mills
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Emily Bruce
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Meei-Li Huang
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Jessica W. Crothers
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Ollivier Hyrien
<jats:p>Reverse transcription–quantitative polymerase chain reaction (RT-qPCR) is used worldwide to test and trace the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). “Extraction-less” or “direct” real time–reverse transcription polymerase chain reaction (RT-PCR) is a transparent and accessible qualitative method for SARS-CoV-2 detection from nasopharyngeal or oral pharyngeal samples with the potential to generate actionable data more quickly, at a lower cost, and with fewer experimental resources than full RT-qPCR. This study engaged 10 global testing sites, including laboratories currently experiencing testing limitations due to reagent or equipment shortages, in an international interlaboratory ring trial. Participating laboratories were provided a common protocol, common reagents, aliquots of identical pooled clinical samples, and purified nucleic acids and used their existing in-house equipment. We observed 100% concordance across laboratories in the correct identification of all positive and negative samples, with highly similar cycle threshold values. The test also performed well when applied to locally collected patient nasopharyngeal samples, provided the viral transport media did not contain charcoal or guanidine, both of which appeared to potently inhibit the RT-PCR reaction. Our results suggest that direct RT-PCR assay methods can be clearly translated across sites utilizing readily available equipment and expertise and are thus a feasible option for more efficient COVID-19 coronavirus disease testing as demanded by the continuing pandemic.</jats:p>
Scopus© Citations 2 3
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Lack of treatment options for endemic helminth infections in Chile affects patient care and public health
(Elsevier BV, 2025-06)
WEITZEL, THOMAS
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María Elvira Balcells
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Claudia P. Cortes
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Alberto Fica
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Renzo Tassara
2
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Three Decades of Hantavirus Management in Chile: Lessons for Europe
(Elsevier BV, 2026-07)
Le Corre, Nicole
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Martínez-Valdebenito, Constanza
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Henriquez, Carolina
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Angulo, Jenniffer
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Acuña, Marco
1
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Neutralizing antibodies in survivors of Sin Nombre and Andes hantavirus infection
(2006-01-01)
Valdivieso, Francisca
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VIAL CLARO, PABLO AGUSTIN
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Ferres, Marcela
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Ye, Chunyan
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Goade, Diane
We evaluated titers of homotypic and heterotypic neutralizing antibodies (NAbs) to Andes and Sin Nombre hantaviruses in plasma samples from 20 patients from Chile and the United States. All but 1 patient had high titers of NAb. None of the plasma samples showed high titers against the heterologous virus.
Scopus© Citations 57 1

VIAL CLARO, PABLO AGUSTIN

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