FIGUEROA VARGAS, ALEJANDRA MABEL
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Item type:Product, Dataset - A comprehensive multimodal MRI and EEG-TMS dataset on the impact of parietal cortex inhibition on decision-making under ambiguity(OSF, 2026); ; GABRIELA BELEN VALDEBENITO OYARZO - Some of the metrics are blocked by yourconsent settings
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Item type:Product, Dataset - Coupling between neural oscillations and white matter integrity reveals cognitive computational profiles following COVID-19(OpenEuro, 2026); ; ;MATÍAS IRIARTE CARTER ;VÍCTOR MÁRQUEZMARIA PAZ DE LOS ANGELES MARTINEZ MOLINA - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Frontoparietal connectivity correlates with working memory performance in multiple sclerosis(2020); ;Claudia Cárcamo ;Rodrigo Henríquez-Ch ;ZAMORANO, FRANCISCOEthel Ciampi<jats:title>Abstract</jats:title><jats:p>Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.</jats:p>Scopus© Citations 22 3 - Some of the metrics are blocked by yourconsent settings
Item type:Product, Dataset - Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations(OpenNeuro, 2024) ;LEONIE MARGARITA KAUSEL KAMP; ; ; 4 - Some of the metrics are blocked by yourconsent settings
Item type:Product, Dataset - The parietal cortex has a causal role in ambiguity computations in humans(2024); ; ; ; LARRAIN VALENZUELA, MARÍA JOSEFINA3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Oscillatory activity underlying cognitive performance in children and adolescents with autism: a systematic review(2024); ;Patricio Soto-Fernández ;Leonie Kausel; <jats:p>Autism spectrum disorder (ASD) is a neurodevelopmental condition that exhibits a widely heterogeneous range of social and cognitive symptoms. This feature has challenged a broad comprehension of this neurodevelopmental disorder and therapeutic efforts to address its difficulties. Current therapeutic strategies have focused primarily on treating behavioral symptoms rather than on brain psychophysiology. During the past years, the emergence of non-invasive brain stimulation techniques (NIBS) has opened alternatives to the design of potential combined treatments focused on the neurophysiopathology of neuropsychiatric disorders like ASD. Such interventions require identifying the key brain mechanisms underlying the symptomatology and cognitive features. Evidence has shown alterations in oscillatory features of the neural ensembles associated with cognitive functions in ASD. In this line, we elaborated a systematic revision of the evidence of alterations in brain oscillations that underlie key cognitive processes that have been shown to be affected in ASD during childhood and adolescence, namely, social cognition, attention, working memory, inhibitory control, and cognitive flexibility. This knowledge could contribute to developing therapies based on NIBS to improve these processes in populations with ASD.</jats:p>9Scopus© Citations 11 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A comprehensive multimodal MRI and EEG-TMS dataset on the impact of parietal cortex inhibition on decision-making under ambiguity(Elsevier BV, 2026-04); ;Gabriela Valdebenito-Oyarzo ;María Paz Martínez-Molina ;Francisco Zamorano4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial(2024); ;Begoña Góngora ;María Francisca Alonso ;Alonso OrtegaPatricio Soto-Fernández<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia and mild cognitive impairment (MCI). The latter can be considered a prodromal phase of some dementias and a critical stage for interventions to postpone the impairment of functionality. Working memory (WM) is a pivotal cognitive function, representing the fundamental element of executive functions. This project proposes an intervention protocol to enhance WM in these users, combining cognitive training with transcranial electrical stimulation of alternating current (tACS). This technique has been suggested to enhance the neuronal plasticity needed for cognitive processes involving oscillatory patterns. WM stands to benefit significantly from this approach, given its well-defined electrophysiological oscillations. Therefore, tACS could potentially boost WM in patients with neurodegenerative diseases.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>This study is a phase IIb randomised, double-blind clinical trial with a 3-month follow-up period. The study participants will be 62 participants diagnosed with MCI, aged over 60, from Valparaíso, Chile. Participants will receive an intervention combining twelve cognitive training sessions with tACS. Participants will receive either tACS or placebo stimulation in eight out of twelve training sessions. Sessions will occur twice weekly over 6 weeks. The primary outcomes will be electroencephalographic measurements through the prefrontal theta oscillatory activity, while the secondary effects will be cognitive assessments of WM. The participants will be evaluated before, immediately after, and 3 months after the end of the intervention.</jats:p> </jats:sec><jats:sec> <jats:title>Discussion</jats:title> <jats:p>The outcomes of this trial will add empirical evidence about the benefits and feasibility of an intervention that combines cognitive training with non-invasive brain stimulation. The objective is to contribute tools for optimal cognitive treatment in patients with MCI. To enhance WM capacity, postpone the impairment of functionality, and obtain a better quality of life.</jats:p> </jats:sec><jats:sec> <jats:title>Trial registration</jats:title> <jats:p>ClinicalTrials.gov NCT05291208. Registered on 28 February 2022. ISRCTN87597719 retrospectively registered on 15 September 2023.</jats:p> </jats:sec>Scopus© Citations 9 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Lateral prefrontal theta oscillations causally drive a computational mechanism underlying conflict expectation and adaptation(2024) ;María Paz Martínez-Molina; ; ;Francisco ZamoranoAntoni Valero-CabréScopus© Citations 3 8