Frontoparietal connectivity correlates with working memory performance in multiple sclerosis
Journal
Scientific Reports
ISSN
2045-2322
Date Issued
2020
Author(s)
Claudia Cárcamo
Rodrigo Henríquez-Ch
ZAMORANO, FRANCISCO
Ethel Ciampi
Reinaldo Uribe-San-Martin
Macarena Vásquez
Francisco Aboitiz
Type
Resource Types::text::journal::journal article
Abstract
<jats:title>Abstract</jats:title><jats:p>Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.</jats:p>
Subjects
adult
;
case-control studies
;
electroencephalography
;
female
;
frontal lobe
;
humans
;
image processing, computer-assisted
;
male
;
memory disorders
;
memory, short-term
;
multiple sclerosis
;
multiple sclerosis, relapsing-remitting
;
parietal lobe
;
reaction time
;
temporal lobe
;
adult
;
case control study
;
diagnostic imaging
;
electroencephalography
;
female
;
frontal lobe
;
human
;
image processing
;
male
;
memory disorder
;
multiple sclerosis
;
parietal lobe
;
pathophysiology
;
physiology
;
psychology
;
reaction time
;
short term memory
;
temporal lobe