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    Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities–focused research
    (2023)
    Sanne Franzen
    ;
    Karen Nuytemans
    ;
    Renelle Bourdage
    ;
    Paulo Caramelli
    ;
    Ratnavalli Ellajosyula
    <jats:title>Abstract</jats:title><jats:p>Frontotemporal dementia (FTD) is one of the leading causes of dementia before age 65 and often manifests as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). FTD's exact clinical presentation varies by culture, language, education, social norms, and other socioeconomic factors; current research and clinical practice, however, is mainly based on studies conducted in North America and Western Europe. Changes in diagnostic criteria and procedures as well as new or adapted cognitive tests are likely needed to take into consideration global diversity. This perspective paper by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment examines how increasing global diversity impacts the clinical presentation, screening, assessment, and diagnosis of FTD and its treatment and care. It subsequently provides recommendations to address immediate needs to advance global FTD research and clinical practice.</jats:p>
      27Scopus© Citations 12
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    A functional dissociation of the left frontal regions that contribute to single word production tasks
    (2021)
    Justyna O. Ekert
    ;
    Diego L. Lorca-Puls
    ;
    GAJARDO VIDAL, ANDREA ELIZABETH  
    ;
    Jennifer T. Crinion
    ;
    Thomas M.H. Hope
    Scopus© Citations 10  2
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    The limitations and challenges in the assessment of executive dysfunction associated with real-world functioning: The opportunity of serious games
    (2023)
    David Martínez-Pernía
    ;
    Loreto Olavarría
    ;
    Baltasar Fernández-Manjón
    ;
    Victoria Cabello
    ;
    HENRIQUEZ, FERNANDO
    Scopus© Citations 5  2
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    Selective Attention and Inhibitory Control of Attention Are Correlated With Music Audiation
    (2020)
    Noemí Grinspun
    ;
    Luc Nijs
    ;
    Leonie Kausel
    ;
    Kelsey Onderdijk
    ;
    Nicolás Sepúlveda
      2Scopus© Citations 14
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    Scopus© Citations 11  2
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    Scopus© Citations 13  2
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    BDNF as a Biomarker of Cognition in Schizophrenia/Psychosis: An Updated Review
    (2021)
    Rodrigo R. Nieto
    ;
    Andrea Carrasco
    ;
    Sebastian Corral
    ;
    Rolando Castillo
    ;
    Pablo A. Gaspar
    <jats:p>Brain Derived Neurotrophic Factor (BDNF) has been linked to cognitive symptoms of schizophrenia, which has been documented in previous reviews by several authors. However, a trend has recently emerged in this field moving from studying schizophrenia as a disease to studying psychosis as a group. This review article focuses on recent BDNF studies in relation to cognition in human subjects during different stages of the psychotic process, including subjects at high risk of developing psychosis, patients at their first episode of psychosis, and patients with chronic schizophrenia. We aim to provide an update of BDNF as a biomarker of cognitive function on human subjects with schizophrenia or earlier stages of psychosis, covering new trends, controversies, current research gaps, and suggest potential future developments in the field. We found that most of current research regarding BDNF and cognitive symptoms in psychosis is done around schizophrenia as a disease. Therefore, it is necessary to expand the study of the relationship between BDNF and cognitive symptoms to psychotic illnesses of different stages and origins.</jats:p>
      1Scopus© Citations 70
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    Default Mode Network, Meditation, and Age-Associated Brain Changes: What Can We Learn from the Impact of Mental Training on Well-Being as a Psychotherapeutic Approach?
    (2019)
    Ricardo Ramírez-Barrantes
    ;
    Marcelo Arancibia
    ;
    Jana Stojanova
    ;
    ASPÉ SÁNCHEZ, MAURICIO ALEJANDRO  
    ;
    Claudio Córdova
    Aging is a physiological process accompanied by cognitive decline, principally in memory and executive functions. Alterations in the connectivity of the default mode network (DMN) have been found to participate in cognitive decline, as well as in several neurocognitive disorders. The DMN has antisynchronic activity with attentional networks (task-positive networks (TPN)), which are critical to executive function and memory. Findings pointing to the regulation of the DMN via activation of TPN suggest that it can be used as a strategy for neuroprotection. Meditation is a noninvasive and nonpharmacological technique proven to increase meta-awareness, a cognitive ability which involves the control of both networks. In this review, we discuss the possibility of facilitating healthy aging through the regulation of networks through meditation. We propose that by practicing specific types of meditation, cognitive decline could be slowed, promoting a healthy lifestyle, which may enhance the quality of life for the elderly.
    Scopus© Citations 38  1
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    Conceptualization, Tasks and Neurobiological Correlates of Self-Regulation in Children and Adolescents: A Systematic Review of the Literature (2015-2020)
    (2022)
    LARRAIN VALENZUELA, MARIA JOSEFINA  
    ;
    Francisca Mardones
    ;
    Elisa Ansoleaga
    ;
    Leonie Kausel
    <jats:sec> <jats:title>Background:</jats:title> <jats:p>Self-regulation is a complex capacity that favors the modification of behavior in accordance with environmental demands.</jats:p> </jats:sec> <jats:sec> <jats:title>Objective:</jats:title> <jats:p>This article aims to review the scientific literature that conceptualizes self-regulation, analyze its potential latent dimensions, identify the instruments used to measure this construct and the empirical findings associated with its neurobiological correlates.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>A systematic review of the scientific literature published between 2015 and 2020. We include 29 empirical studies on children and adolescents self-regulatory capacity after combining the words self-regulation with cognition, brain and neurosciences.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Most of the articles included are from North America. A PICOS analysis was performed to increase understanding of self-regulatory capacity. Two dimensions of self-regulation are identified, contributing to a more global conceptualization of the concept of self-regulation; A cognitive dimension associated with executive functions, effortful control and inhibitory control, among others, and a dimension associated with personality, including traits such as irritability, impulsivity, openness and hyperactivity. Next, the instruments used to measure self-regulation are described, followed by a report of the important neurobiological findings, specifically, activation of the anterior cingulate cortex, dorsolateral prefrontal and ventromedial prefrontal cortex.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>Self-regulatory capacity is associated with a complex functioning that favors adaptive behavior and has neurobiological correlates.</jats:p> </jats:sec>
    Scopus© Citations 2  7