GAJARDO VIDAL, ANDREA ELIZABETH

Preferred name
GAJARDO VIDAL, ANDREA ELIZABETH
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Email
agajardo@udd.cl
ORCID
0000-0003-3946-0795
Scopus Author ID
57194767907
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    How right hemisphere damage after stroke can impair speech comprehension
    (2018)
    GAJARDO VIDAL, ANDREA ELIZABETH  
    ;
    Diego L Lorca-Puls
    ;
    Thomas M H Hope
    ;
    Oiwi Parker Jones
    ;
    Mohamed L Seghier
      4Scopus© Citations 64
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      2
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    Scopus© Citations 20  1
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      19Scopus© Citations 4
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    The impact of pre-stroke formal education on language test performance in aphasic and non-aphasic stroke survivors
    (Informa UK Limited, 2024-12-05)
    Sophie M. Roberts
    ;
    Rachel Bruce
    ;
    Thomas M. H. Hope
    ;
    Sharon Geva
    ;
    Storm Anderson
      2Scopus© Citations 2
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    A functional dissociation of the left frontal regions that contribute to single word production tasks
    (2021)
    Justyna O. Ekert
    ;
    Diego L. Lorca-Puls
    ;
    GAJARDO VIDAL, ANDREA ELIZABETH  
    ;
    Jennifer T. Crinion
    ;
    Thomas M.H. Hope
    Scopus© Citations 10  2
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    The Effect of Right Temporal Lobe Gliomas on Left and Right Hemisphere Neural Processing During Speech Perception and Production Tasks
    (2022)
    Adam Kenji Yamamoto
    ;
    Ana Sanjuán
    ;
    Rebecca Pope
    ;
    Oiwi Parker Jones
    ;
    Thomas M. H. Hope
    Using fMRI, we investigated how right temporal lobe gliomas affecting the posterior superior temporal sulcus alter neural processing observed during speech perception and production tasks. Behavioural language testing showed that three pre-operative neurosurgical patients with grade 2, grade 3 or grade 4 tumours had the same pattern of mild language impairment in the domains of object naming and written word comprehension. When matching heard words for semantic relatedness (a speech perception task), these patients showed under-activation in the tumour infiltrated right superior temporal lobe compared to 61 neurotypical participants and 16 patients with tumours that preserved the right postero-superior temporal lobe, with enhanced activation within the (tumour-free) contralateral left superior temporal lobe. In contrast, when correctly naming objects (a speech production task), the patients with right postero-superior temporal lobe tumours showed higher activation than both control groups in the same right postero-superior temporal lobe region that was under-activated during auditory semantic matching. The task dependent pattern of under-activation during the auditory speech task and over-activation during object naming was also observed in eight stroke patients with right hemisphere infarcts that affected the right postero-superior temporal lobe compared to eight stroke patients with right hemisphere infarcts that spared it. These task-specific and site-specific cross-pathology effects highlight the importance of the right temporal lobe for language processing and motivate further study of how right temporal lobe tumours affect language performance and neural reorganisation. These findings may have important implications for surgical management of these patients, as knowledge of the regions showing functional reorganisation may help to avoid their inadvertent damage during neurosurgery.
      10Scopus© Citations 8
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    Network anatomy in logopenic variant of primary progressive aphasia
    (2023)
    Maria Luisa Mandelli
    ;
    Diego L. Lorca‐Puls
    ;
    Sladjana Lukic
    ;
    Maxime Montembeault
    ;
    GAJARDO VIDAL, ANDREA ELIZABETH  
    <jats:title>Abstract</jats:title><jats:p>The logopenic variant of primary progressive aphasia (lvPPA) is a neurodegenerative syndrome characterized linguistically by gradual loss of repetition and naming skills resulting from left posterior temporal and inferior parietal atrophy. Here, we sought to identify which specific cortical loci are initially targeted by the disease (epicenters) and investigate whether atrophy spreads through predetermined networks. First, we used cross‐sectional structural MRI data from individuals with lvPPA to define putative disease epicenters using a surface‐based approach paired with an anatomically fine‐grained parcellation of the cortical surface (i.e., HCP‐MMP1.0 atlas). Second, we combined cross‐sectional functional MRI data from healthy controls and longitudinal structural MRI data from individuals with lvPPA to derive the epicenter‐seeded resting‐state networks most relevant to lvPPA symptomatology and ascertain whether functional connectivity in these networks predicts longitudinal atrophy spread in lvPPA. Our results show that two partially distinct brain networks anchored to the left anterior angular and posterior superior temporal gyri epicenters were preferentially associated with sentence repetition and naming skills in lvPPA. Critically, the strength of connectivity within these two networks in the neurologically‐intact brain significantly predicted longitudinal atrophy progression in lvPPA. Taken together, our findings indicate that atrophy progression in lvPPA, starting from inferior parietal and temporoparietal junction regions, predominantly follows at least two partially nonoverlapping pathways, which may influence the heterogeneity in clinical presentation and prognosis.</jats:p>
    Scopus© Citations 10  2
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    Lesions that do or do not impair digit span: a study of 816 stroke survivors
    (2021)
    Sharon Geva
    ;
    Teodros Truneh
    ;
    Mohamed L Seghier
    ;
    Thomas M H Hope
    ;
    Alex P Leff
    <jats:title>Abstract</jats:title> <jats:p>Prior studies have reported inconsistency in the lesion sites associated with verbal short-term memory impairments. Here we asked: How many different lesion sites can account for selective impairments in verbal short-term memory that persist over time, and how consistently do these lesion sites impair verbal short-term memory? We assessed verbal short-term memory impairments using a forward digit span task from the Comprehensive Aphasia Test. First, we identified the incidence of digit span impairments in a sample of 816 stroke survivors (541 males/275 females; age at stroke onset 56 ± 13 years; time post-stroke 4.4 ± 5.2 years). Second, we studied the lesion sites in a subgroup of these patients (n = 39) with left hemisphere damage and selective digit span impairment—defined as impaired digit span with unimpaired spoken picture naming and spoken word comprehension (tests of speech production and speech perception, respectively). Third, we examined how often these lesion sites were observed in patients who either had no digit span impairments or digit span impairments that co-occurred with difficulties in speech perception and/or production tasks. Digit span impairments were observed in 222/816 patients. Almost all (199/222 = 90%) had left hemisphere damage to five small regions in basal ganglia and/or temporo-parietal areas. Even complete damage to one or more of these five regions was not consistently associated with persistent digit span impairment. However, when the same regions were spared, only 5% (23/455) presented with digit span impairments. These data suggest that verbal short-term memory impairments are most consistently associated with damage to left temporo-parietal and basal ganglia structures. Sparing of these regions very rarely results in persistently poor verbal short-term memory. These findings have clinical implications for predicting recovery of verbal short-term memory after stroke.</jats:p>
      1Scopus© Citations 14  2
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    Scopus© Citations 11  1