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    Early developmental screening tools constructed in Latin American countries: umbrella review
    (Publicidad Permanyer, SLU, 2025-04-09)
    SCHONHAUT BERMAN, LUISA  
    ;
    Antonia Valdés
    ;
    Ilan Oppenheimer
    ;
    Antonio Rizzoli-Córdoba
    ;
    Rolando Rivera
      2Scopus© Citations 2
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    Exploring the feasibility and effectiveness of a naturalistic family centered intervention to enhance early interactions in toddlers with Down syndrome
    (Springer Science and Business Media LLC, 2025-04-09)
    Ana Mendoza-García
    ;
    Andrés Aparicio
    ;
    Paulina Sofía Arango
    ;
    TENORIO DELGADO, MARCELA  
    This study analyses the feasibility and effectiveness of BabyMICARE, a manualised intervention programme aimed at improving the interactions between caregivers and infants and toddlers with Down syndrome. The programme’s goal is to enhance caregivers’ sensitivity and reduce directivity during early interactions, particularly during play and daily routines. A pre-test and post-test design was used with 40 dyads of infants with Down syndrome and their caregivers, who were divided into a control group (n = 20) and an intervention group (n = 20), based on baseline scores in key interaction subscales. Sessions were conducted over 10 weeks by trained psychologists. Parent-infant interaction was assessed using the MACI coding system, which measures aspects such as sensitive responsiveness, directivity and the level of reciprocity between the parent and the child. The programme showed high feasibility, with a 100% attendance rate but some rescheduling. Caregivers evaluated it positively. The intervention group demonstrated significant improvements in five of eight MACI scales, particularly in sensitive responsiveness and nondirectiveness, while no changes were observed in the control group. The results suggest that BabyMICARE is a feasible and effective intervention for promoting more responsive, less directive interactions, which may be crucial in fostering children’s development.
      3
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    TGFβ links EBV to multisystem inflammatory syndrome in children
    (Springer Science and Business Media LLC, 2025-03-12)
    Carl Christoph Goetzke
    ;
    Mona Massoud
    ;
    Stefan Frischbutter
    ;
    Gabriela Maria Guerra
    ;
    Marta Ferreira-Gomes
    <jats:title>Abstract</jats:title> <jats:p>In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock<jats:sup>1</jats:sup> termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion<jats:sup>2</jats:sup> and systemic hyperinflammation<jats:sup>3</jats:sup>. The pathogenesis of MIS-C remains largely unknown. Here we show that acute MIS-C is characterized by impaired reactivation of virus-reactive memory T cells, which depends on increased serum levels of the cytokine TGFβ resembling those that occur during severe COVID-19 (refs. <jats:sup>4,5</jats:sup>). This functional impairment in T cell reactivity is accompanied by the presence of TGFβ-response signatures in T cells, B cells and monocytes along with reduced antigen-presentation capabilities of monocytes, and can be reversed by blocking TGFβ. Furthermore, T cell receptor repertoires of patients with MIS-C exhibit expansion of T cells expressing TCRVβ21.3, resembling Epstein–Barr virus (EBV)-reactive T cell clones capable of eliminating EBV-infected B cells. Additionally, serum TGFβ in patients with MIS-C can trigger EBV reactivation, which is reversible with TGFβ blockade. Clinically, the TGFβ-induced defect in T cell reactivity correlates with a higher EBV seroprevalence in patients with MIS-C compared with age-matched controls, along with the occurrence of EBV reactivation. Our findings establish a connection between SARS-CoV-2 infection and COVID-19 sequelae in children, in which impaired T cell cytotoxicity triggered by TGFβ overproduction leads to EBV reactivation and subsequent hyperinflammation.</jats:p>
    Scopus© Citations 4  2
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    Clinical, immunologic, and genetic characteristics of 148 patients with natural killer cell deficiency
    (Elsevier BV, 2025-05)
    Manar Abdalgani
    ;
    Evelyn R. Hernandez
    ;
    Luis A. Pedroza
    ;
    Ivan K. Chinn
    ;
    Lisa R. Forbes Satter
    Scopus© Citations 1  2
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    Validación de un modelo de enseñanza musical para la educación en general
    (2024)
    Felipe Porflitt Becerra
    ;
    Rolando Andrés Jeldres Zamorano
    ;
    Alfonso Norero Saavedra
    <jats:p>Introducción: El presente artículo revisa el estado del arte en base a la visión actual y antigua de la enseñanza de la música, mostrando concordancias y discordancias, con el objetivo de construir y validar un modelo de enseñanza de la música. Metodología: Se realizó una revisión de literatura para determinar las categorías de construcción y posterior diseño del modelo, el cual fue validado por docentes de distintos rangos etarios de la educación. Resultados: Se muestra una valoración alta al modelo en sí mismo, así como también, por el lado contrario, algunas discrepancias para docentes de enseñanza formal y no formal. Asimismo, existió una tensión entre si el uso de la teoría de la música es estrictamente necesaria en la educación, así como el orden jerárquico en interpretación musical respecto al ritmo, melodía y armonía, respectivamente. Discusión: Según lo relevado en este estudio, el modelo se valida para todo nivel educativo, y, además, los paradigmas antiguos y modernos pueden convivir en vez de ser excluyentes. Conclusiones: Un modelo para la enseñanza de la música en general en el siglo XXI debe tener la suficiente flexibilidad para que cada docente lo utilice confiando en su experticia.</jats:p>
      4
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    Preschool and School Aggression: Adaptation and Validation of the Preschool Social Behavior Scale in Chile
    (2023)
    VARELA TORRES, JORGE JAVIER  
    ;
    Paula Mujica
    ;
    Mariavictoria Benavente
    ;
    MELIPILLAN ARANEDA, EDMUNDO ROBERTO  
    ;
    Paula Villacura
    <jats:p>Recognizing aggressive behavior at an early age is vital to identify problematic trajectories that may increase the risk of behavioral and social adaptation problems at school and during adolescence. This requires scales capable of measuring this behavior. In this study, the Scale of Preschool Social Behavior (psbs) - Teacher Form was validated using a Confirmatory Factor Analysis (cfa) in a national context. We used a sample of 538 children and 12 educators from 4 kindergartens and 5 public schools in Santiago, Chile. The results revealed two main factors: aggression and pro-social behavior, similar to the original scale. This study contributes to the early detection of physical and relational aggression in the preschool stage through the development of reliable measurements that guide prevention programs.</jats:p>
    Scopus© Citations 2  1
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    Scopus© Citations 44  12