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Gut Microbiota‐Derived Extracellular Vesicles Influence Alcohol Intake Preferences in Rats
(Wiley, 2025-03)
Macarena Díaz‐Ubilla
;
Aliosha I. Figueroa‐Valdés
;
Hugo E. Tobar
;
María Elena Quintanilla
;
Eugenio Díaz
<jats:title>ABSTRACT</jats:title><jats:p>Growing preclinical and clinical evidence suggests a link between gut microbiota dysbiosis and problematic alcohol consumption. Extracellular vesicles (EVs) are key mediators involved in bacteria‐to‐host communication. However, their potential role in mediating addictive behaviour remains unexplored. This study investigates the role of gut microbiota‐derived bacterial extracellular vesicles (bEVs) in driving high alcohol consumption. bEVs were isolated from the gut microbiota of a high alcohol‐drinking rat strain (UChB rats), either ethanol‐naïve or following chronic alcohol consumption and administered intraperitoneally or orally to alcohol‐rejecting male and female Wistar rats. Both types of UChB‐derived bEVs increased Wistar's voluntary alcohol consumption (three bottle choice test) up to 10‐fold (<jats:italic>p</jats:italic> < 0.0001), indicating that bEVs are able and sufficient to transmit drinking behaviour across different rat strains. Molecular analysis revealed that bEVs administration did not induce systemic or brain inflammation in the recipient animals, suggesting that the increased alcohol intake triggered by UChB‐derived bEVs operates through an inflammation‐independent mechanism. Furthermore, we demonstrate that the vagus nerve mediates the bEV‐induced increase in alcohol consumption, as bilateral vagotomy completely abolished the high drinking behaviour induced by both intraperitoneally injected and orally administered bEVs. Thus, this study identifies bEVs as a novel mechanism underlying gut microbiota‐induced high alcohol intake in a vagus nerve‐dependent manner.</jats:p>
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Aspirin and N‐acetylcysteine co‐administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation‐oxidative stress self‐perpetuation
(2019)
Yedy Israel
;
María Elena Quintanilla
;
EZQUER, EDUARDO FERNANDO
;
Paola Morales
;
Daniela Santapau
Scopus© Citations 34 2
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A dual mechanism fully blocks ethanol relapse: Role of vagal innervation
(2022)
María Elena Quintanilla
;
EZQUER, EDUARDO FERNANDO
;
Paola Morales
;
Daniela Santapau
;
EZQUER, EDUARDO MARCELO
3
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A dual treatment blocks alcohol binge-drinking relapse: Microbiota as a new player
(2022)
EZQUER, EDUARDO FERNANDO
;
María Elena Quintanilla
;
Paola Morales
;
Daniela Santapau
;
MUNITA SEPULVEDA, JOSE MANUEL
Scopus© Citations 22 2
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Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats
(2019)
EZQUER, EDUARDO FERNANDO
;
María Elena Quintanilla
;
Paola Morales
;
EZQUER, EDUARDO MARCELO
;
Carolyne Lespay-Rebolledo
1Scopus© Citations 31 2
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Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking
(2019)
EZQUER, EDUARDO FERNANDO
;
María Elena Quintanilla
;
Paola Morales
;
Daniela Santapau
;
EZQUER, EDUARDO MARCELO
1Scopus© Citations 60 5

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