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    Early high-sensitivity troponin elevation and short-term mortality in sepsis: a systematic review with meta-analysis
    (Springer Science and Business Media LLC, 2025-02-14)
    Abraham I. J. Gajardo
    ;
    Santiago Ferrière-Steinert
    ;
    Joaquín Valenzuela Jiménez
    ;
    Sebastián Heskia Araya
    ;
    Thomas Kouyoumdjian Carvajal
    Abstract Background Serum cardiac troponin (cTn) elevation is a well-established phenomenon in sepsis. However, the clinical signifcance of this phenomenon with high-sensitivity (hs) assays and the current sepsis defnition needs to be settled. Research Question What is the association between early serum cTn levels measured by hs-assays and the risk of short-term mortality in septic patients? Study Design and Methods We conducted a systematic review using a comprehensive PubMed, Scopus, and Embase search. Studies were eligible if they reported association data on early hs-cTn and mortality in an adult sample with sepsis that met the Sepsis-3 defnition. For the synthesis of the efect of hs-cTn on mortality, we applied random efect models on the pooled unadjusted and adjusted odds ratio (OR and aOR, respectively) of elevated vs. normal hs-cTn serum values, and on the crude standardized mean diference (SMD) of hs-cTn between survivors and non-survivors. Results In total, 6242 patients from 17 studies were included, with short-term mortality rates ranging from 16.9% to 53.8%. Using a crude analysis, non-survivor patients showed higher hs-cTn than survivors (SMD of 0.87, 95%CI: 0.41–1.33). Elevated hs-cTn was associated with increased mortality (OR=1.78, 95% CI: 1.41–2.25). However, this prognostic efect was absent in studies that adjusted for diferent confounders (aOR=1.06, 95% CI: 0.99–1.14). Discussion and Conclusions Non-survivors of sepsis exhibited signifcantly elevated hs-cTn levels. While elevated hs-cTn levels are associated with an increased risk of mortality, they are not independently associated with this outcome in sepsis
      1Scopus© Citations 19
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    Need estimates of psychiatric beds: a systematic review and meta-analysis
    (2024)
    Adrian P Mundt
    ;
    Enzo Rozas-Serri
    ;
    Francesco D. Fritz
    ;
    Sabine Delhey
    ;
    Mathias Siebenförcher
    <jats:title>Abstract</jats:title> <jats:p>This study aimed to review and synthesize the need estimates for psychiatric beds, explore how they changed over time and compare them against the prevalence of actually existing beds. We searched PubMed, Embase classic and Embase, PsycINFO and PsycIndex, Open Grey, Google Scholar, Global Health EBSCO and Proquest Dissertations, from inception to September 13, 2022. Publications providing estimates for the required number of psychiatric inpatient beds were included. Need estimates, length of stay, and year of the estimate were extracted. Need estimates were synthesized using medians and interquartile ranges (IQRs). We also computed prevalence ratios of the need estimates and the existing bed capacities at the same time and place. Sixty-five publications with 98 estimates were identified. Estimates for bed needs were trending lower until 2000, after which they stabilized. The twenty-six most recent estimates after 2000 were submitted to data synthesis (<jats:italic>n</jats:italic> = 15 for beds with unspecified length of stay, <jats:italic>n</jats:italic> = 7 for short-stay, and <jats:italic>n</jats:italic> = 4 for long-stay beds). Median estimates per 100 000 population were 47 (IQR: 39 to 50) beds with unspecified length of stay, 28 (IQR: 23 to 31) beds for short-stay, and 10 (IQR: 8 to 11) for long-stay beds. The median prevalence ratio of need estimates and the actual bed prevalence was 1.8 (IQR: 1.3 to 2.3) from 2000 onwards. Historically, the need estimates for psychiatric beds have decreased until about 2000. In the past two decades, they were stable over time and consistently higher than the actual bed numbers provided.</jats:p>
      2Scopus© Citations 8
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    Varieties of Time in Business Sustainability Research: An Integrative Review and Research Agenda
    (2023)
    Matilde Morales-Raya
    ;
    MUÑOZ ROMÁN, PABLO ANDRÉS  
    <jats:p> In this article, we tackle the lack of clarity in the conceptualization and substantive use of time in business sustainability research. We do so by means of an integrative review that synthesizes 172 papers published over the last 20 years across seven subject areas within business and management research. From our review, we developed a typology that highlights three primary categories that differentiate various conceptualizations and uses of time in business sustainability literature: (a) temporal resourcing, (b) temporal structuring, and (c) temporal prospecting for sustainability. The typology organizes a body of literature that remains scattered, provides conceptual clarity, and opens avenues for future empirical research and theorization in the space. </jats:p>
    Scopus© Citations 3  2
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    Scopus© Citations 21  1
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    The effectiveness of joint mobilization techniques for range of motion in adult patients with primary adhesive capsulitis of the shoulder: a systematic review and meta-analysis
    (2018)
    Jonathan Zavala-González
    ;
    Francisco Pavez-Baeza
    ;
    Héctor Gutiérrez-Espinoza
    ;
    Cristian Olguín-Huerta
      25Scopus© Citations 33
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    Children’s experience of physical harms and exposure to family violence from others’ drinking in nine societies
    (2019)
    Anne-Marie Laslett
    ;
    Oliver Stanesby
    ;
    Kathryn Graham
    ;
    Sarah Callinan
    ;
    Katherine J. Karriker-Jaffe
      2Scopus© Citations 17
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    Many Labs 2: Investigating Variation in Replicability Across Samples and Settings
    (2018)
    Richard A. Klein
    ;
    Michelangelo Vianello
    ;
    Fred Hasselman
    ;
    Byron G. Adams
    ;
    Reginald B. Adams
    <jats:p> We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance ( p &lt; .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion ( p &lt; .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely high-powered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (&lt; 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied. </jats:p>
    Scopus© Citations 750  5
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      14
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    Scopus© Citations 25  2
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      7Scopus© Citations 7