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HSV-1 alters lipid metabolism and induces lipid droplet accumulation in functionally impaired mouse dendritic cells
(Elsevier BV, 2025-05)
Mónica A. Farías
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Felipe A. Cancino
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Areli J. Navarro
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DUARTE PEÑALOZA, LUISA FERNANDA
;
Abel A. Soto
Scopus© Citations 6 8
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Complementary Effect of Maternal Sildenafil and Fetal Tracheal Occlusion Improves Lung Development in the Rabbit Model of Congenital Diaphragmatic Hernia
(2020)
Francesca Maria Russo
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Marina Gabriela Monteiro Carvalho Mori Da Cunha
;
Julio Jimenez
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Flore Lesage
;
Mary Patrice Eastwood
<jats:sec> <jats:title>Objective:</jats:title> <jats:p>To evaluate the effect of combining antenatal sildenafil with fetal tracheal occlusion (TO) in fetal rabbits with surgically induced congenital diaphragmatic hernia (CDH).</jats:p> </jats:sec> <jats:sec> <jats:title>Background:</jats:title> <jats:p>Although antenatal sildenafil administration rescues vascular abnormalities in lungs of fetal rabbits with CDH, it only partially improves airway morphometry. We hypothesized that we could additionally stimulate lung growth by combining this medical treatment with fetal TO.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>CDH was created on gestational day (GD)23 (n=54). Does were randomized to receive either sildenafil 10 mg/kg/d or placebo by subcutaneous injection from GD24 to GD30. On GD28, fetuses were randomly assigned to TO or sham neck dissection. At term (GD30) fetuses were delivered, ventilated, and finally harvested for histological and molecular analyses. Unoperated littermates served as controls.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>The lung-to-body-weight ratio was significantly reduced in sham-CDH fetuses either (1.2 ± 0.3% vs 2.3 ± 0.3% in controls, <jats:italic toggle="yes">P</jats:italic>=0.0003). Sildenafil had no effect on this parameter, while CDH fetuses undergoing TO had a lung-to-body-weight ratio comparable to that of controls (2.5 ± 0.8%, <jats:italic toggle="yes">P</jats:italic><0.0001). Sildenafil alone induced an improvement in the mean terminal bronchiolar density (2.5 ± 0.8 br/mm<jats:sup>2</jats:sup> vs 3.5 ± 0.9 br/mm<jats:sup>2</jats:sup>, <jats:italic toggle="yes">P</jats:italic>=0.043) and lung mechanics (static elastance 61 ± 36 cmH<jats:sub>2</jats:sub>O /mL vs 113 ± 40 cmH<jats:sub>2</jats:sub>O/mL, <jats:italic toggle="yes">P</jats:italic>=0.008), but both effects were more pronounced in fetuses undergoing additional TO (2.1 ± 0.8 br/mm<jats:sup>2</jats:sup>, <jats:italic toggle="yes">P</jats:italic>=0.001 and 31 ± 9 cmH<jats:sub>2</jats:sub>O/mL, <jats:italic toggle="yes">P</jats:italic><0.0001 respectively). Both CDH-sham and CDH-TO fetuses treated with placebo had an increased medial wall thickness of peripheral pulmonary vessels (41.9 ± 2.9% and 41.8 ± 3.2%, vs 24.0 ± 2.9% in controls, <jats:italic toggle="yes">P</jats:italic><0.0001). CDH fetuses treated with sildenafil, either with or without TO, had a medial thickness in the normal range (29.4% ± 2.6%). Finally, TO reduced gene expression of vascular endothelial growth factor and surfactant protein A and B, but this effect was counteracted by sildenafil.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>In the rabbit model for CDH, the combination of maternal sildenafil and TO has a complementary effect on vascular and parenchymal lung development.</jats:p> </jats:sec>
3Scopus© Citations 19
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Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy
(2013)
Sebastián D. Calligaris
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Manuel Lecanda
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Felipe Solis
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EZQUER, EDUARDO MARCELO
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Jaime Gutiérrez
2Scopus© Citations 142
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Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood–brain barrier function
(2022)
Bárbara S. Casas
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Gabriela Vitória
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Catalina P. Prieto
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Mariana Casas
;
Carlos Chacón
1Scopus© Citations 21
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Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids
(2022)
Veronika Ramovs
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Hans Janssen
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FUENTES BUSTOS, MARIA IGNACIA
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Amandine Pitaval
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Walid Rachidi
26Scopus© Citations 46
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Indications for Helicobacter pylori Eradication: Do We Need to Consider to Screen and Treat Asymptomatic Children?
(2018)
YALDA CECILIA LUCERO ALVAREZ
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Sergio George
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Miguel O’Ryan
13Scopus© Citations 1
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Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives
(2016)
Luis E. León
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Sweta Rani
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Mauricio Fernandez
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Martín Larico
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SEBASTIAN DANTE CALLIGARIS CAPRIOGLIO
<jats:p>The prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a diastolic dysfunction and cardiac remodelling without signs of hypertension and coronary artery diseases. In an early stage, it is an asymptomatic disease; however, clinical studies demonstrate that diabetic myocardia are more vulnerable to injury derived by acute myocardial infarct and are the worst prognosis for rehabilitation. Currently, biochemical and imaging diagnostic methods are unable to detect subclinical manifestation of the disease (prior to diastolic dysfunction). In this review, we elaborately discuss the current scientific evidences to propose circulating microRNAs as promising biomarkers for early detection of diabetic cardiomyopathy and, then, to identify patients at high risk of diabetic cardiomyopathy development. Moreover, here we summarise the research strategies to identify miRNAs as potential biomarkers, present limitations, challenges, and future perspectives.</jats:p>
4Scopus© Citations 44
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High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis
(2016)
Johanna Abrigo
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Juan Carlos Rivera
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Javier Aravena
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Daniel Cabrera
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Felipe Simon
<jats:p>Obesity can lead to skeletal muscle atrophy, a pathological condition characterized by the loss of strength and muscle mass. A feature of muscle atrophy is a decrease of myofibrillar proteins as a result of ubiquitin proteasome pathway overactivation, as evidenced by increased expression of the muscle-specific ubiquitin ligases atrogin-1 and MuRF-1. Additionally, other mechanisms are related to muscle wasting, including oxidative stress, myonuclear apoptosis, and autophagy. Stem cells are an emerging therapy in the treatment of chronic diseases such as high fat diet-induced obesity. Mesenchymal stem cells (MSCs) are a population of self-renewable and undifferentiated cells present in the bone marrow and other mesenchymal tissues of adult individuals. The present study is the first to analyze the effects of systemic MSC administration on high fat diet-induced skeletal muscle atrophy in the tibialis anterior of mice. Treatment with MSCs reduced losses of muscle strength and mass, decreases of fiber diameter and myosin heavy chain protein levels, and fiber type transitions. Underlying these antiatrophic effects, MSC administration also decreased ubiquitin proteasome pathway activation, oxidative stress, and myonuclear apoptosis. These results are the first to indicate that systemically administered MSCs could prevent muscle wasting associated with high fat diet-induced obesity and diabetes.</jats:p>
6Scopus© Citations 94
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Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancer
(2015)
Iván Roa
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Gonzalo de Toro
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Fernanda Fernández
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Anakaren Game
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Sergio Muñoz
Scopus© Citations 22 2
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Partial microduplication in the histone acetyltransferase complex member KANSL1 is associated with congenital heart defects in 22q11.2 microdeletion syndrome patients
(2017)
Luis E. León
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BENAVIDES GONZALEZ, FELIPE ORLANDO
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Karena Espinoza
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Patricia Alvarez
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VIAL COX, MARIA CECILIA
29 1Scopus© Citations 27

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