DUARTE PEÑALOZA, LUISA FERNANDA

Preferred name

Main Affiliation

Facultad de Medicina Clínica Alemana Universidad del Desarrollo

ORCID

0000-0003-1828-1800

Goggle Scholar

https://scholar.google.com/citations?hl=es&user=5uaf2PYAAAAJ

Now showing 1 - 10 of 10

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Reactive Oxygen and Reactive Nitrogen Species in Herpesvirus Infections: Mechanisms, Clinical Implications, and Therapeutic Opportunities
(SAGE Publications, 2026-07-22)
Reyes-Ramírez, Rodrigo
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Navarro, Areli J.
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Ortiz, Gerardo E.
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Tognarelli, Eduardo I.
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López-Hernández, Dayesi
Significance: Herpesvirus infections are highly prevalent in the human population, causing a broad spectrum of diseases ranging from mild to severe that affect numerous tissues, although most infections remain asymptomatic. These viruses establish lifelong infections through latency and may reactivate at different frequencies, with or without clinical symptoms. To counteract microbial infections, host cells have evolved molecular mechanisms that interfere with viral replication, including the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Recent Advances: ROS and RNS are not merely antimicrobial products but also regulators of pathogen gene expression, immune modulation, and cell fate decisions, with excessive production leading to oxidative stress and cellular damage, among other effects. Notably, many viruses, including herpesviruses, modulate ROS and RNS production in infected cells to promote viral replication and evade the host immune response. Critical Issues: In this review, we examine the complex interplay between ROS, RNS, and herpesvirus infections. The available literature suggests (i) that herpesviruses from all three subfamilies exploit ROS and RNS as molecular switches for viral replication and immune evasion, (ii) that the specific ROS and RNS species and pathways hijacked by these viruses differ by subfamily, creating distinct and targetable redox vulnerabilities, and (iii) that antioxidant interventions selectively restoring physiological redox balances could represent efficacious antiviral strategies. Future Directions: Highlighting emerging therapeutic strategies that modulate redox balance to control viral replication and disease progression, this review underscores the need for mechanistic and controlled clinical studies to validate virus subfamily-tailored, redox-based antiviral approaches. Antioxid. Redox Signal. 00, 000–000.
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Editorial: Neuroinflammation: mechanisms and therapeutic interventions
(Frontiers Media SA, 2026-03-24)
Ma. Cecilia Opazo
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EZQUER, EDUARDO MARCELO
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Mayra A. Machuca
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DUARTE PEÑALOZA, LUISA FERNANDA
1
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Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease
(2024)
DUARTE PEÑALOZA, LUISA FERNANDA
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Verónica Villalobos
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Mónica A. Farías
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Ma. Andreina Rangel-Ramírez
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Enrique González-Madrid
Experimental autoimmune encephalomyelitis (EAE) is a demyelinating disease affecting the central nervous system (CNS) in animals that parallels several clinical and molecular traits of multiple sclerosis in humans. Herpes simplex virus type 1 (HSV-1) infection mainly causes cold sores and eye diseases, yet eventually, it can also reach the CNS, leading to acute encephalitis. Notably, a significant proportion of healthy individuals are likely to have asymptomatic HSV-1 brain infection with chronic brain inflammation due to persistent latent infection in neurons. Because cellular senescence is suggested as a potential factor contributing to the development of various neurodegenerative disorders, including multiple sclerosis, and viral infections may induce a premature senescence state in the CNS, potentially increasing susceptibility to such disorders, here we examine the presence of senescence-related markers in the brains and spinal cords of mice with asymptomatic HSV-1 brain infection, EAE, and both conditions. Across all scenarios, we find a significant increases of senescence biomarkers in the CNS with some differences depending on the analyzed group. Notably, some senescence biomarkers are exclusively observed in mice with the combined conditions. These results indicate that asymptomatic HSV-1 brain infection and EAE associate with a significant expression of senescence biomarkers in the CNS.
Scopus© Citations 2 5
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Dataset - HSV-1 alters lipid metabolism and induces lipid droplet accumulation in functionally impaired mouse dendritic cells
(National Center for Biotechnology, 2025)
DUARTE PEÑALOZA, LUISA FERNANDA
1
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Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair
(Frontiers Media SA, 2025-10-29)
Javier Carbone-Schellman
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Javiera Fontecilla-Escobar
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Nicolás Sales-Salinas
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William F. Chaparro-Pico
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Alfredo Molina-Berríos
<jats:p>Although significant progress has been made in medicine and antimicrobial research, viral infections continue to pose a critical global health challenge, particularly when they involve the central nervous system (CNS). Despite advances in vaccines, antiviral agents, and small molecule therapeutics, current strategies remain insufficient to address the complex consequences of many CNS infections fully. Notably, many viruses are neurotropic and can invade the CNS, triggering infectious neuroinflammation that often lead to chronic neurological disorders and lasting morbidity. Current therapeutic approaches are largely ineffective in preventing or reversing this long-term neurological damage, underscoring the urgent need for innovative prophylactic and therapeutic interventions. Mesenchymal stem cells (MSCs) have emerged as a promising strategy to counteract chronic neuroinflammation and promote tissue repair following viral CNS infections. This review provides a comprehensive overview of CNS viral infection and neuroinflammation, including epidemiology and pathophysiology, and critically examines the limitations of existing treatments, particularly their inability to mitigate persistent neurological sequelae. Furthermore, we summarize recent preclinical and clinical studies investigating the use of MSCs in the context of CNS viral infections, highlighting their immunomodulatory and neuroprotective mechanisms, and discuss the challenges and future directions for MSC-based therapies in clinical settings.</jats:p>
Scopus© Citations 1 1
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HSV-1 alters lipid metabolism and induces lipid droplet accumulation in functionally impaired mouse dendritic cells
(Elsevier BV, 2025-05)
Mónica A. Farías
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Felipe A. Cancino
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Areli J. Navarro
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DUARTE PEÑALOZA, LUISA FERNANDA
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Abel A. Soto
Scopus© Citations 6 8
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Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine
(Elsevier BV, 2025-08)
Yohana Martínez-Balboa
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Linmar Rodríguez-Guilarte
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Constanza Méndez
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Mariana Ríos
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Daniela B. Rivera
3Scopus© Citations 1
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Characterization of Hydrogel Beads for the Gradual Release of Origanum vulgare L. Essential Oil and Evaluation of Their Antifungal Activity Against Candida albicans
(MDPI AG, 2025-09-05)
Victoria Concha
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Mario Díaz-Dosque
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DUARTE PEÑALOZA, LUISA FERNANDA
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José A. Jara
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Alfredo Molina-Berríos
Candida albicans infections are associated with high morbidity and mortality worldwide. Current antifungal therapies are limited by adverse effects and the emergence of resistant strains, which compromise long-term efficacy. Previous studies have shown that Origanum vulgare L. essential oil (OvEO) possesses strong antifungal activity; however, its volatility and physicochemical instability hinder clinical application. The aim of this study was to encapsulate OvEO in a hydrogel and evaluate its release kinetics, chemical composition, structural properties, and antifungal activity. We assessed its release kinetics, chemical composition, structural characteristics (FTIR; SEM), and antifungal activity against C. albicans. OvEO was successfully encapsulated into hydrogel beads, enabling a gradual release profile, with in vitro release of phenolic compounds reaching 100% at 48 min. SEM revealed an irregular surface with small pores and crystalline aggregates distributed across the bead surface. OvEO-loaded hydrogel beads inhibited C. albicans growth with an IC50 of 0.15 ± 0.05 mg/L for strain 90029 and 0.2 ± 0.06 mg/L for strain 10231. At these concentrations, adhesion to abiotic surfaces was reduced by 60–80%. These findings support the potential of OvEO-loaded hydrogel beads as an alternative approach for the treatment of fungal infections, offering a complementary strategy to current antifungal agents.
1
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Tackling cutaneous herpes simplex virus disease with topical immunomodulators—a call to action
(American Society for Microbiology, 2025-03-13)
DUARTE PEÑALOZA, LUISA FERNANDA
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Javier Carbone-Schellman
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Susan M. Bueno
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Alexis M. Kalergis
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Claudia A. Riedel
Antivirals play important roles in restricting viral diseases. Nevertheless, they act on a relatively limited number of viruses and occasionally display partial effectiveness in some tissues or against escape variants. Although vaccination remains the most cost-effective approach for preventing microbial diseases, developing prophylactic or therapeutic solutions for pathogens, such as herpes simplex viruses (HSVs), that effectively reduce their clinical manifestations in the skin has proven exceptionally challenging despite extensive research. Alternatively, a less explored approach for tackling HSV skin infection involves using topical immunomodulatory molecules to potentiate the host’s innate antiviral immune responses. When applied directly to herpetic skin lesions where viral antigen is present, this strategy has the potential to elicit virus-specific adaptive immunity. Based on currently available data, we foresee substantial potential for this approach in addressing HSV skin infections, along with additional prospects to advance understanding of skin biology and apply relevant new findings to other dermatological conditions. However, due to the limited number of case studies evaluating this method and its safety profile, particularly in immunocompromised individuals and pregnant women, further research is crucial, especially to assess the effects of immunomodulators in these vulnerable populations. Here, we revisit and discuss the use of immunomodulatory molecules for potentiating the host immune response against HSV skin infection and call for action for increased research and clinical trials regarding the possible benefits of this latter strategy for treating HSV cutaneous disease and recurrences. We also revisit and discuss antivirals and vaccine candidates against HSVs.
Scopus© Citations 2 7
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Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring
(Springer Science and Business Media LLC, 2025-11-26)
Enrique González-Madrid
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Ma. Andreina Rangel-Ramírez
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María C. Opazo
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Sebastián A. Espinoza
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Daniela Elgueta
Scopus© Citations 1 4

DUARTE PEÑALOZA, LUISA FERNANDA

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