Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives
Journal
Journal of Diabetes Research
ISSN
2314-6745
2314-6753
Date Issued
2016
Author(s)
Luis E. León
Sweta Rani
Mauricio Fernandez
Martín Larico
SEBASTIAN DANTE CALLIGARIS CAPRIOGLIO
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>The prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a diastolic dysfunction and cardiac remodelling without signs of hypertension and coronary artery diseases. In an early stage, it is an asymptomatic disease; however, clinical studies demonstrate that diabetic myocardia are more vulnerable to injury derived by acute myocardial infarct and are the worst prognosis for rehabilitation. Currently, biochemical and imaging diagnostic methods are unable to detect subclinical manifestation of the disease (prior to diastolic dysfunction). In this review, we elaborately discuss the current scientific evidences to propose circulating microRNAs as promising biomarkers for early detection of diabetic cardiomyopathy and, then, to identify patients at high risk of diabetic cardiomyopathy development. Moreover, here we summarise the research strategies to identify miRNAs as potential biomarkers, present limitations, challenges, and future perspectives.</jats:p>
Subjects
heart-failure
;
circulating micrornas
;
cardiac-hypertrophy
;
oxidative stress
;
mouse model
;
plasma
;
expression
;
biomarkers
;
mellitus
;
exosomes