Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker
Journal
Viruses
ISSN
1999-4915
Date Issued
2023
Author(s)
Gabriela Meza-Fuentes
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
Hantavirus cardiopulmonary syndrome (HCPS) is a severe respiratory illness primarily associated with microvascular endothelial changes, particularly in the lungs. However, the role of the pulmonary epithelium in HCPS pathogenesis remains unclear. This study explores the potential of soluble Receptors for Advanced Glycation End-products (sRAGE) as a biomarker for assessing pulmonary epithelial damage in severe HCPS, challenging the prevailing view that endothelial dysfunction is the sole driver of this syndrome. We conducted a cross-sectional study on critically ill HCPS patients, categorizing them into mild HCPS, severe HCPS, and negative control groups. Plasma sRAGE levels were measured, revealing significant differences between the severe HCPS group and controls. Our findings suggest that sRAGE holds promise as an indicator of pulmonary epithelial injury in HCPS and may aid in tracking disease progression and guiding therapeutic strategies. This study brings clarity on the importance of investigating the pulmonary epithelium’s role in HCPS pathogenesis, offering potential avenues for enhanced diagnostic precision and support in this critical public health concern.
Cite this document
Meza-Fuentes, G., López, R., Vial, C., Cortes, L. J., Retamal, M. A., Delgado, I., & Vial, P. (2023). Assessing pulmonary epithelial damage in hantavirus cardiopulmonary syndrome: Challenging the predominant role of vascular endothelium through srage as a potential biomarker. Viruses, 15(10), 1995. https://doi.org/10.3390/v15101995
Subjects
acute respiratory distress syndrome
;
hantavirus cardiopulmonary syndrome
;
srage
;
biomarkers
;
communicable diseases
;
cross-sectional studies
;
endothelium, vascular
;
hantavirus infections
;
hantavirus pulmonary syndrome
;
humans
;
lung
;
lung injury
;
orthohantavirus
;
receptor for advanced glycation end products
;
advanced glycation end product receptor
;
biological marker
;
advanced glycation end product receptor
;
biological marker
;
adolescent
;
adult
;
aged
;
article
;
clinical article
;
cohort analysis
;
controlled study
;
critically ill patient
;
cross-sectional study
;
disease exacerbation
;
disease severity
;
dyspnea
;
endothelial dysfunction
;
enzyme linked immunosorbent assay
;
female
;
hantavirus pulmonary syndrome
;
hematocrit
;
horowitz index
;
human
;
lung epithelium
;
male
;
observational study
;
oxygenation
;
platelet count
;
pulmonary epithelial damage
;
respiratory tract disease
;
retrospective study
;
sequential organ failure assessment score
;
thorax radiography
;
vascular endothelium
;
communicable disease
;
hantavirus
;
hantavirus infection
;
hantavirus pulmonary syndrome
;
lung
;
lung injury
;
pathology
;
vascular endothelium