RETAMAL LUCERO, MAURICIO ANTONIO

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Dataset - The role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release
(GitHub, 2024)
RETAMAL LUCERO, MAURICIO ANTONIO
;
ALARCÓN, RODRIGO
2
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Tumor hypoxia shapes natural killer cell anticancer activities
(Springer Science and Business Media LLC, 2025-05-30)
RETAMAL LUCERO, MAURICIO ANTONIO
;
Flavio Salazar-Onfray
;
Fermín E. González
;
Andrés Tittarelli
1
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Preface
(2024-01-01)
Mammano, Fabio
;
RETAMAL LUCERO, MAURICIO ANTONIO
1
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Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: Gap junctions versus hemichannels
(2013)
Jegan Iyyathurai
;
Catheleyne D'hondt
;
Nan Wang
;
Marijke De Bock
;
Bernard Himpens
5Scopus© Citations 86
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Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats
(2020)
Claudia M. Lucero
;
David C. Andrade
;
Camilo Toledo
;
Hugo S. Díaz
;
Katherin V. Pereyra
<jats:title>Abstract</jats:title><jats:p>Alterations in connexins and specifically in 43 isoform (Cx43) in the heart have been associated with a high incidence of arrhythmogenesis and sudden death in several cardiac diseases. We propose to determine salutary effect of Cx43 mimetic peptide Gap27 in the progression of heart failure. High-output heart failure was induced by volume overload using the arterio-venous fistula model (AV-Shunt) in adult male rats. Four weeks after AV-Shunt surgery, the Cx43 mimetic peptide Gap27 or scrambled peptide, were administered via osmotic minipumps (AV-Shunt<jats:sub>Gap27</jats:sub> or AV-Shunt<jats:sub>Scr</jats:sub>) for 4 weeks. Cardiac volumes, arrhythmias, function and remodeling were determined at 8 weeks after AV-Shunt surgeries. At 8<jats:sup>th</jats:sup> week, AV-Shunt<jats:sub>Gap27</jats:sub> showed a marked decrease in the progression of cardiac deterioration and showed a significant improvement in cardiac functions measured by intraventricular pressure-volume loops. Furthermore, AV-Shunt<jats:sub>Gap27</jats:sub> showed less cardiac arrhythmogenesis and cardiac hypertrophy index compared to AV-Shunt<jats:sub>Scr</jats:sub>. Gap27 treatment results in no change Cx43 expression in the heart of AV-Shunt rats. Our results strongly suggest that Cx43 play a pivotal role in the progression of cardiac dysfunction and arrhythmogenesis in high-output heart failure; furthermore, support the use of Cx43 mimetic peptide Gap27 as an effective therapeutic tool to reduce the progression of cardiac dysfunction in high-output heart failure.</jats:p>
Scopus© Citations 30 1
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Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins
(2016)
Bernardo I. Pinto
;
Isaac E. García
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Amaury Pupo
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RETAMAL LUCERO, MAURICIO ANTONIO
;
Agustín D. Martínez
2Scopus© Citations 13
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Editorial: Free Fatty Acids as Signaling Molecules: Role of Free Fatty Acid Receptors and CD36
(2022)
Carlos Puebla
;
Eugenia Morselli
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Naim Akhtar Khan
;
Mauricio A. Retamal
Scopus© Citations 6 1
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Platinum analogs from a chemical and biological point of view
(2022-10-06)
CAMPODONICO GALDAMES, PAOLA ROSSANA
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RETAMAL LUCERO, MAURICIO ANTONIO
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Cortés Fuentes, Ignacio
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Gormaz, Juan G.
1
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Extracellular Cysteine in Connexins: Role as Redox Sensors
(2016)
RETAMAL LUCERO, MAURICIO ANTONIO
;
Isaac E. García
;
Bernardo I. Pinto
;
Amaury Pupo
;
David Báez
Scopus© Citations 30 1
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Ultra‐Processed Foods and Markers of Systemic Inflammation in Children
(Wiley, 2025-09)
Camila Awad
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RUBILAR RAMIREZ, PAOLA ANDREA
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HIRMAS ADAUY, MACARENA SOLEDAD
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Verónica Iglesias
;
María Pía Muñoz
Diets high in ultra-processed foods (UPF) have been associated with negative health outcomes in adults; however, UPF's impact on children's health and their underlying mechanisms remain underexplored, despite the rising prevalence of their intake in younger populations. We aimed to investigate the association between UPF intake and systemic inflammation in primary school children. This study included 450 children aged 7-10 years participating in a birth cohort in Arica, Chile (2023). Using the NOVA food classification system, we calculated the intake of UPF (expressed in %kcal) from a 44-item food frequency questionnaire (FFQ). The associations between UPF intake (exposure) and an array of cytokine levels (IL-6, IL-8, IL-10, IL-12, IL1 beta, TNF-alpha) were assessed using multiple linear regression models, adjusted for relevant covariates. The mean (SD) UPF intake was 29% (10.5%) of the total energy intake. Some of the associations appeared non-linear; therefore, participants were grouped into tertiles of UPF intake. In adjusted models, a suggestive trend across tertiles was observed for IL-1 beta (trend p-value 0.01). Stratified analyses by age suggested an association between UPF intake and IL-6 in older children (>= 9 years) only (p-value for interaction = 0.02). We found potential associations between UPF intake and cytokine levels in school-aged children. These results may suggest inflammation as a mechanism underlying the adverse health consequences of UPF consumption in children.
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RETAMAL LUCERO, MAURICIO ANTONIO

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