Seroprevalence of Natural and Acquired Immunity against the SARS-CoV-2 Virus in a Population Cohort from Two Chilean Cities, 2020–2022
Journal
Viruses
ISSN
1999-4915
Date Issued
2023
Author(s)
Loreto Núñez-Franz
Muriel Ramírez-Santana
Macarena Said
Luis Canales
Gloria Icaza
Rubén Quezada-Gaete
Kathya Olivares
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>Background: Chile has achieved the highest coverage for vaccines against the SARS-CoV-2 virus worldwide. Objective: To assess the progression of immunity (natural and acquired by vaccine) in a cohort from two Chilean cities. Methods: Individuals (n = 386) who participated in three phases of population-based serial prevalence studies were included (2020–2021 and 2022). Presence of SARS-CoV-2 antibodies was measured in serum. Data including time of vaccination and type of vaccine received were analysed with descriptive statistics. Results: Seroprevalence was 3.6% in the first round and increased to 96.9% in the second and 98.7% in the third. In the third round, 75% of individuals who had received the basal full scheme were seropositive at 180 days or more since their last dose; 98% of individuals who received one booster dose were seropositive at 180 days or more, and 100% participants who received two boosters were seropositive, regardless of time since their last dose. Participants receiving mRNA vaccines had higher seroprevalence rates over time. Conclusions: The high vaccination coverage in Chile enabled the population to maintain high levels of antibodies. Vaccination boosters are essential to maintain immunity over time, which also depends on the type of vaccine administered.</jats:p>
Cite this document
Núñez-Franz, L., Ramírez-Santana, M., Rubilar, P., Vial, C., Apablaza, M., González, C., Said, M., Olivares, K., Cortés, L. J., Hormazábal, J., Canales, L., Vial, P., Icaza, G., Quezada-Gaete, R., & Aguilera, X. (2023). Seroprevalence of natural and acquired immunity against the sars-cov-2 virus in a population cohort from two chilean cities, 2020–2022. Viruses, 15(1), 201. https://doi.org/10.3390/v15010201
Project(s)
Subjects
antibodies
;
chile
;
covid-19
;
immunity
;
seroepidemiology
;
seroprevalence
;
vaccines
;
adaptive immunity
;
antibodies, viral
;
chile
;
cities
;
covid-19
;
humans
;
sars-cov-2
;
seroepidemiologic studies
;
coronavac
;
immunoglobulin g antibody
;
sars-cov-2 antibody
;
sars-cov-2 vaccine
;
virus antibody
;
adaptive immunity
;
adolescent
;
adult
;
aged
;
article
;
child
;
chilean
;
cohort analysis
;
coronavirus disease 2019
;
crowding (area)
;
educational status
;
enzyme linked immunosorbent assay
;
female
;
follow up
;
health insurance
;
human
;
human experiment
;
humoral immunity
;
immunoassay
;
innate immunity
;
lateral flow immunochromatography
;
male
;
middle aged
;
nonhuman
;
nutritional status
;
polymerase chain reaction
;
seroepidemiology
;
seroprevalence
;
severe acute respiratory syndrome coronavirus 2
;
vaccination
;
vaccination coverage
;
adaptive immunity
;
chile
;
city
;
epidemiology
;
prevention and control