CASTILLO LABORDE, CARLA CECILIA
Preferred name
CASTILLO LABORDE, CARLA CECILIA
Main Affiliation
Email
carlacastillo@udd.cl
ORCID
0000-0001-6004-5882
Scopus Author ID
36699176800
29 results
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Item type:Publication, Personas mayores y cuidadores: experiencias con tecnologías digitales en salud en tres regiones de Chile(Centro de Estudios Publicos, 2025-07-24); ; 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Transmission dynamics and control of COVID-19 in Chile, March-October, 2020(2021); Scopus© Citations 45 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Immunization and SARS-CoV-2 Antibody Seroprevalence in a Country with High Vaccination Coverage: Lessons from Chile(2022); ; ; <jats:p>Chile is among the most successful nations worldwide in terms of its COVID-19 vaccine rollout. By 31 December 2021, 84.1% of the population was fully vaccinated, and 56.1% received booster doses using different COVID-19 vaccines. In this context, we aimed to estimate the prevalence of anti-SARS-CoV-2 antibodies following the infection and vaccination campaign. Using a three-stage stratified sampling, we performed a population-based cross-sectional serosurvey based on a representative sample of three Chilean cities. Selected participants were blood-sampled on-site and answered a short COVID-19 and vaccination history questionnaire using Wantai SARS-CoV-2 Ab ELISA to determine seroprevalence. We recruited 2198 individuals aged 7–93 between 5 October and 25 November 2021; 2132 individuals received COVID-19 vaccinations (97%), 67 (3.1%) received one dose, 2065 (93.9%) received two doses, and 936 received the booster jab (42.6%). Antibody seroprevalence reached 97.3%, ranging from 40.9% among those not vaccinated to 99.8% in those with booster doses (OR = 674.6, 154.8–2938.5). SARS-CoV-2 antibodies were associated with vaccination, previous COVID-19 diagnosis, age group, and city of residence. In contrast, we found no significant differences in the type of vaccine used, education, nationality, or type of health insurance. We found a seroprevalence close to 100%, primarily due to the successful vaccination program, which strongly emphasizes universal access.</jats:p>6Scopus© Citations 12 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Poverty and ethnic patterns in COVID-19 excess mortality: evidence from Chile, 2020-2022(Oxford University Press (OUP), 2025-12-10); ; Elienai Joaquin-DamasThe COVID-19 pandemic highlighted deep-rooted health inequities globally, with marginalized populations showing disproportionate disease burden. We employed Serfling regression models and multivariable analyses to estimate excess mortality across geographic, demographic, and poverty groups from 2020 to 2022 in Chile. Elderly populations (80+ years) experienced the highest excess mortality (267.35 per 10 000 population), more than 8 times higher than those under 80 years (30.80 per 10 000 population). Multivariable linear regression models showed both Indigenous proportion (coefficient = 53.66, P &lt; .001) and elderly population proportion (coefficient = 5.68, P &lt; .01) as the strong predictors of comuna level excess mortality. Poverty correlated significantly with excess mortality (r = 0.23, P &lt; .001) but this association weakened after adjustment for other covariates in multivariable models. Excess mortality peaked in 2021 rather than in 2020 for most groups, with males initially experiencing higher rates during early pandemic waves. Spatial analyses revealed statistically significant clustering (Moran’s I = 0.119, P &lt; .001) with identifiable hotspots in northern Chile and parts of the south. These findings indicated persistent mortality disparities by age and Indigenous status, independent of poverty, and highlight the urgent need for equity-focused pandemic preparedness. An effective pandemic response should integrate biomedical measures, such as vaccination, with culturally grounded strategies that address structural barriers and the broader social determinants of health.</jats:p>1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Wide percutaneous access to pancreatic necrosis with self-expandable stent: new application (with video)(2011); 1 - Some of the metrics are blocked by yourconsent settings
Item type:Product, 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, High-flow bronchopleural fistula: Endobronchial management(2006-04-01); 7Scopus© Citations 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Mental health consequences of long-term stays in refugee camps: preliminary evidence from Moria(2021); 13Scopus© Citations 41 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Assessment of pesticide residues in processed foods in Chile(2011); 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Modelling cost-effectiveness of syphilis detection strategies in prisoners: exploratory exercise in a Chilean male prison(2021); ; Macarena Hirmas-Adauy<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Syphilis, together with other sexually transmitted infections, remains a global public health problem that is far from controlled. People deprived of liberty are a vulnerable population. Control activities in prisons rely mostly on passive case detection, despite the existence of affordable alternatives that would allow switching to active case-finding strategies. Our objective was to develop a mathematical modelling framework for cost-effectiveness evaluation, from a health system perspective, of different approaches using rapid tests for the detection of syphilis in inmates' populations and to explore the results based on a Chilean male prison population.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>A compartmental model was developed to characterize the transmission dynamics of syphilis inside a prison with the ongoing strategy (passive case detection, with VRDL + FTA-ABS), considering the entrance and exit of inmates over a 40 year period. The model allows simulation of the implementation of a reverse algorithm for the current situation (rapid test + VDRL), different screening strategies (entry point, massive periodically; both with rapid test + VDRL) and treatment of detected cases. The parameters for the exploratory exercise were obtained from systematic searches of indexed and grey literature and field work (EQ-5D questionnaire application and key actors interviews). Probabilistic sensitivity analysis was conducted to account for uncertainty in relevant parameters.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>The proposed framework allows the evaluation of different detection strategies. In this study, all the strategies were cost-effective in the baseline scenario when considering an ICER threshold of 1 Chilean GDP per capita (US$15,000). The strategies most likely to be cost-effective (over 80% probability) were: current situation with reverse algorithm, entry point screening and mass screening every two years; the latter was the most effective, achieving the lowest prevalence (0.7% and 1.7% over the period versus the 3% prevalence in the current situation).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Mathematical modelling that considers the performance of different tests and detection strategies could be a useful tool for decision making. The exploratory results show the efficiency of adopting both the use of the rapid tests and performing active case detection to significantly reduce the burden of syphilis in Chilean prisons in the near future.</jats:p> </jats:sec>Scopus© Citations 5 1
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