Transmission dynamics and control of COVID-19 in Chile, March-October, 2020

Journal
PLOS Neglected Tropical Diseases
ISSN
1935-2735
Date Issued
2021
Author(s)
Amna Tariq
Eduardo A. Undurraga
Katia Vogt-Geisse
Ruiyan Luo
Richard Rothenberg
Gerardo Chowell
Type
Resource Types::text::journal::journal article
Scopus ID
2-s2.0-85100190594
WoS ID
WOS:000612932700004
DOI
URL
URL Institutional Repository
Abstract
<jats:p>Since the detection of the first case of COVID-19 in Chile on March 3<jats:sup>rd</jats:sup>, 2020, a total of 513,188 cases, including ~14,302 deaths have been reported in Chile as of November 2<jats:sup>nd</jats:sup>, 2020. Here, we estimate the reproduction number throughout the epidemic in Chile and study the effectiveness of control interventions especially the effectiveness of lockdowns by conducting short-term forecasts based on the early transmission dynamics of COVID-19. Chile’s incidence curve displays early sub-exponential growth dynamics with the deceleration of growth parameter,<jats:italic>p</jats:italic>, estimated at 0.8 (95% CI: 0.7, 0.8) and the reproduction number,<jats:italic>R</jats:italic>, estimated at 1.8 (95% CI: 1.6, 1.9). Our findings indicate that the control measures at the start of the epidemic significantly slowed down the spread of the virus. However, the relaxation of restrictions and spread of the virus in low-income neighborhoods in May led to a new surge of infections, followed by the reimposition of lockdowns in Greater Santiago and other municipalities. These measures have decelerated the virus spread with<jats:italic>R</jats:italic>estimated at ~0.96 (95% CI: 0.95, 0.98) as of November 2<jats:sup>nd</jats:sup>, 2020. The early sub-exponential growth trend (<jats:italic>p</jats:italic>~0.8) of the COVID-19 epidemic transformed into a linear growth trend (<jats:italic>p</jats:italic>~0.5) as of July 7<jats:sup>th</jats:sup>, 2020, after the reimposition of lockdowns. While the broad scale social distancing interventions have slowed the virus spread, the number of new COVID-19 cases continue to accrue, underscoring the need for persistent social distancing and active case detection and isolation efforts to maintain the epidemic under control.</jats:p>
Cite this document
Tariq, A., Undurraga, E. A., Laborde, C. C., Vogt-Geisse, K., Luo, R., Rothenberg, R., & Chowell, G. (2021). Transmission dynamics and control of COVID-19 in Chile, March-October, 2020. PLOS Neglected Tropical Diseases, 15(1), e0009070. https://doi.org/10.1371/journal.pntd.0009070
Dataset(s)
Subjects
epidemic

; 

characterize

; 

coronavirus

; 

growth

; 

basic reproduction number

; 

chile

; 

covid-19

; 

epidemics

; 

humans

; 

incidence

; 

models, biological

; 

physical distancing

; 

article

; 

basic reproduction number

; 

calibration

; 

chile

; 

coronavirus disease 2019

; 

epidemic

; 

generalized growth model

; 

generalized logistic growth model

; 

human

; 

incidence

; 

infection control

; 

lowest income group

; 

mathematical model

; 

social distancing

; 

uncertainty

; 

virus transmission

; 

biological model

; 

diagnosis

; 

epidemic

; 

epidemiology

; 

prevention and control