Project Title
THE EFFECTS OF COLCHICINE ON CORONARY MICROVASCULAR REPERFUSION AND RESIDUAL INFLAMMATORY RISK IN PATIENTS WITH ACUTE CORONARY SYNDROME.
Partner Organisations
Internal ID
1210655
Principal Investigator
Gonzalo Javier Martínez Rodríguez
Start Date
2020
Investigators
Organisations
v

Filters

Settings

Now showing 1 - 3 of 3
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Role of inflammation and evidence for the use of colchicine in patients with acute coronary syndrome
    (2024)
    Juan Francisco Bulnes
    ;
    Leticia González
    ;
    Leonardo Velásquez
    ;
    María Paz Orellana
    ;
    MUÑOZ VENTURELLI, PAULA ANDREA  
    <jats:p>Acute Coronary Syndrome (ACS) significantly contributes to cardiovascular death worldwide. ACS may arise from the disruption of an atherosclerotic plaque, ultimately leading to acute ischemia and myocardial infarction. In the pathogenesis of atherosclerosis, inflammation assumes a pivotal role, not solely in the initiation and complications of atherosclerotic plaque formation, but also in the myocardial response to ischemic insult. Acute inflammatory processes, coupled with time to reperfusion, orchestrate ischemic and reperfusion injuries, dictating infarct magnitude and acute left ventricular (LV) remodeling. Conversely, chronic inflammation, alongside neurohumoral activation, governs persistent LV remodeling. The interplay between chronic LV remodeling and recurrent ischemic episodes delineates the progression of the disease toward heart failure and cardiovascular death. Colchicine exerts anti-inflammatory properties affecting both the myocardium and atherosclerotic plaque by modulating the activity of monocyte/macrophages, neutrophils, and platelets. This modulation can potentially result in a more favorable LV remodeling and forestalls the recurrence of ACS. This narrative review aims to delineate the role of inflammation across the different phases of ACS pathophysiology and describe the mechanistic underpinnings of colchicine, exploring its purported role in modulating each of these stages.</jats:p>
    Scopus© Citations 25  1
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    The Role of Colchicine in Atherosclerosis: From Bench to Bedside
    (2022)
    Leticia González
    ;
    Juan Francisco Bulnes
    ;
    María Paz Orellana
    ;
    MUÑOZ VENTURELLI, PAULA ANDREA  
    ;
    Gonzalo Martínez Rodriguez
    Inflammation is a key feature of atherosclerosis. The inflammatory process is involved in all stages of disease progression, from the early formation of plaque to its instability and disruption, leading to clinical events. This strongly suggests that the use of anti-inflammatory agents might improve both atherosclerosis progression and cardiovascular outcomes. Colchicine, an alkaloid derived from the flower Colchicum autumnale, has been used for years in the treatment of inflammatory pathologies, including Gout, Mediterranean Fever, and Pericarditis. Colchicine is known to act over microtubules, inducing depolymerization, and over the NLRP3 inflammasome, which might explain its known anti-inflammatory properties. Recent evidence has shown the therapeutic potential of colchicine in the management of atherosclerosis and its complications, with limited adverse effects. In this review, we summarize the current knowledge regarding colchicine mechanisms of action and pharmacokinetics, as well as the available evidence on the use of colchicine for the treatment of coronary artery disease, covering basic, translational, and clinical studies.
    Scopus© Citations 27  1
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Scopus© Citations 21  1