Role of inflammation and evidence for the use of colchicine in patients with acute coronary syndrome
Journal
Frontiers in Cardiovascular Medicine
ISSN
2297-055X
Date Issued
2024
Author(s)
Juan Francisco Bulnes
Leticia González
Leonardo Velásquez
María Paz Orellana
Gonzalo Martínez
Type
journal-article
Abstract
<jats:p>Acute Coronary Syndrome (ACS) significantly contributes to cardiovascular death worldwide. ACS may arise from the disruption of an atherosclerotic plaque, ultimately leading to acute ischemia and myocardial infarction. In the pathogenesis of atherosclerosis, inflammation assumes a pivotal role, not solely in the initiation and complications of atherosclerotic plaque formation, but also in the myocardial response to ischemic insult. Acute inflammatory processes, coupled with time to reperfusion, orchestrate ischemic and reperfusion injuries, dictating infarct magnitude and acute left ventricular (LV) remodeling. Conversely, chronic inflammation, alongside neurohumoral activation, governs persistent LV remodeling. The interplay between chronic LV remodeling and recurrent ischemic episodes delineates the progression of the disease toward heart failure and cardiovascular death. Colchicine exerts anti-inflammatory properties affecting both the myocardium and atherosclerotic plaque by modulating the activity of monocyte/macrophages, neutrophils, and platelets. This modulation can potentially result in a more favorable LV remodeling and forestalls the recurrence of ACS. This narrative review aims to delineate the role of inflammation across the different phases of ACS pathophysiology and describe the mechanistic underpinnings of colchicine, exploring its purported role in modulating each of these stages.</jats:p>
Cite this document
Bulnes, J. F., González, L., Velásquez, L., Orellana, M. P., Venturelli, P. M., & Martínez, G. (2024). Role of inflammation and evidence for the use of colchicine in patients with acute coronary syndrome. Frontiers in Cardiovascular Medicine, 11, 1356023. https://doi.org/10.3389/fcvm.2024.1356023
Project(s)
Subjects
colchicine
;
acute coronary syndrome
;
myocardial infarction
;
inflammasome
;
netosis