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Project Title
Evaluation of the therapeutic effect of mesenchymal stem cell acelular derivate on drug induced steatosis, in model of normal and impaired liver regeneration capacity
Partner Organisations
Internal ID
1150589
Principal Investigator
Status
TERMINADO
Start Date
15 March 2015
End Date
18 March 2015
Investigators
Fernando Ezquer

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Now showing 1 - 8 of 8
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Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats

2016 , Yedy Israel , EZQUER, EDUARDO FERNANDO , María Elena Quintanilla , Paola Morales , EZQUER, EDUARDO MARCELO , Mario Herrera-Marschitz

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Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line

2017 , Yedy Israel , Eduardo Karahanian , EZQUER, EDUARDO FERNANDO , Paola Morales , EZQUER, EDUARDO MARCELO , Mario Rivera-Meza , Mario Herrera-Marschitz , María E. Quintanilla

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High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis

2016 , Johanna Abrigo , Juan Carlos Rivera , Javier Aravena , Daniel Cabrera , Felipe Simon , EZQUER, EDUARDO FERNANDO , EZQUER, EDUARDO MARCELO , Claudio Cabello-Verrugio

Obesity can lead to skeletal muscle atrophy, a pathological condition characterized by the loss of strength and muscle mass. A feature of muscle atrophy is a decrease of myofibrillar proteins as a result of ubiquitin proteasome pathway overactivation, as evidenced by increased expression of the muscle-specific ubiquitin ligases atrogin-1 and MuRF-1. Additionally, other mechanisms are related to muscle wasting, including oxidative stress, myonuclear apoptosis, and autophagy. Stem cells are an emerging therapy in the treatment of chronic diseases such as high fat diet-induced obesity. Mesenchymal stem cells (MSCs) are a population of self-renewable and undifferentiated cells present in the bone marrow and other mesenchymal tissues of adult individuals. The present study is the first to analyze the effects of systemic MSC administration on high fat diet-induced skeletal muscle atrophy in the tibialis anterior of mice. Treatment with MSCs reduced losses of muscle strength and mass, decreases of fiber diameter and myosin heavy chain protein levels, and fiber type transitions. Underlying these antiatrophic effects, MSC administration also decreased ubiquitin proteasome pathway activation, oxidative stress, and myonuclear apoptosis. These results are the first to indicate that systemically administered MSCs could prevent muscle wasting associated with high fat diet-induced obesity and diabetes.

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Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options

2019 , Yedy Israel , Quintanilla, María Elena , Paola Ezquer , Mario Morales , Eduardo Rivera-Meza , Marcelo Karahanian , EZQUER, EDUARDO FERNANDO

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Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking

2018 , EZQUER, EDUARDO FERNANDO , Paola Morales , María Elena Quintanilla , Carolyne Lespay-Rebolledo , Daniela Santapau , EZQUER, EDUARDO MARCELO , Mario Herrera-Marschitz , Yedy Israel

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Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats

2019 , EZQUER, EDUARDO FERNANDO , María Elena Quintanilla , Paola Morales , EZQUER, EDUARDO MARCELO , Carolyne Lespay-Rebolledo , Mario Herrera-Marschitz , Yedy Israel

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Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy

2017 , EZQUER, EDUARDO FERNANDO , Javiera Bahamonde , Ya-Lin Huang , EZQUER, EDUARDO MARCELO

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Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking

2019 , EZQUER, EDUARDO FERNANDO , María Elena Quintanilla , Paola Morales , Daniela Santapau , EZQUER, EDUARDO MARCELO , Marcelo J. Kogan , Edison Salas-Huenuleo , Mario Herrera-Marschitz , Yedy Israel

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