LOBOS GONZALEZ, LORENA DE LOURDES
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LOBOS GONZALEZ, LORENA DE LOURDES
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llobos@udd.cl
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28767817600

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Dataset 2 - Lactadherin: From a Well-Known Breast Tumor Marker to a Possible Player in Extracellular Vesicle-Mediated Cancer Progression

2022 , LOBOS GONZALEZ, LORENA DE LOURDES , EDUARDO FELIPE DURÁN JARA

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Dataset 1 - Lactadherin: From a Well-Known Breast Tumor Marker to a Possible Player in Extracellular Vesicle-Mediated Cancer Progression

2022 , LOBOS GONZALEZ, LORENA DE LOURDES , EDUARDO FELIPE DURÁN JARA

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Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis

2019 , America Campos , Renato Burgos-Ravanal , Maria Fernanda Gonzalez , Ricardo Huilcaman , LOBOS GONZALEZ, LORENA DE LOURDES , Andrew Quest

Caveolin-1 (CAV1) is a scaffolding protein with a controversial role in cancer. This review will initially discuss earlier studies focused on the role as a tumor suppressor before elaborating subsequently on those relating to function of the protein as a promoter of metastasis. Different mechanisms are summarized illustrating how CAV1 promotes such traits upon expression in cancer cells (intrinsic mechanisms). More recently, it has become apparent that CAV1 is also a secreted protein that can be included into exosomes where it plays a significant role in determining cargo composition. Thus, we will also discuss how CAV1 containing exosomes from metastatic cells promote malignant traits in more benign recipient cells (extrinsic mechanisms). This ability appears, at least in part, attributable to the transfer of specific cargos present due to CAV1 rather than the transfer of CAV1 itself. The evolution of how our perception of CAV1 function has changed since its discovery is summarized graphically in a time line figure.

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90 Role of microrna-145 in epithelial ovarian cancer

2020 , Carmen Romero , Maritza P Garrido , Ignacio Torres , Andrea Hernandez , Jonas Chnaiderman , Margarita Vega , Alberto Selman , Jessica Preisler , LOBOS GONZALEZ, LORENA DE LOURDES

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Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities

2024 , Eduardo Durán-Jara , Matías del Campo , Valentina Gutiérrez , Ignacio Wichmann , César Trigo , EZQUER, EDUARDO MARCELO , LOBOS GONZALEZ, LORENA DE LOURDES

Background: Tumor-derived small extracellular vesicles (sEVs) can promote tumorigenic and metastatic capacities in less aggressive recipient cells mainly through the biomolecules in their cargo. However, despite recent advances, the specific molecules orchestrating these changes are not completely defined. Lactadherin is a secreted glycoprotein typically found in the milk fat globule membrane. Its overexpression has been associated with increased tumorigenesis and metastasis in breast cancer (BC) and other tumors. However, neither its presence in sEVs secreted by BC cells, nor its role in sEV-mediated intercellular communication have been described. The present study focused on the role of lactadherin-containing sEVs from metastatic MDA-MB-231 triple-negative BC (TNBC) cells (sEV-MDA231) in the promotion of pro-metastatic capacities in non-tumorigenic and non-metastatic recipient cells in vitro, as well as their pro-metastatic role in a murine model of peritoneal carcinomatosis. Results: We show that lactadherin is present in sEVs secreted by BC cells and it is higher in sEV-MDA231 compared with the other BC cell-secreted sEVs measured through ELISA. Incubation of non-metastatic recipient cells with sEV-MDA231 increases their migration and, to some extent, their tumoroid formation capacity but not their anchorage-independent growth. Remarkably, lactadherin blockade in sEV-MDA231 results in a significant decrease of those sEV-mediated changes in vitro. Similarly, intraperitoneally treatment of mice with MDA-MB-231 BC cells and sEV-MDA231 greatly increase the formation of malignant ascites and tumor micronodules, effects that were significantly inhibited when lactadherin was previously blocked in those sEV-MDA231. Conclusions: As to our knowledge, our study provides the first evidence on the role of lactadherin in metastatic BC cell-secreted sEVs as promoter of: (i) metastatic capacities in less aggressive recipient cells, and ii) the formation of malignant ascites and metastatic tumor nodules. These results increase our understanding on the role of lactadherin in sEVs as promoter of metastatic capacities which can be used as a therapeutic option for BC and other malignancies

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Pannexin-1 expression in tumor cells correlates with colon cancer progression and survival

2024 , Aaron Fierro-Arenas , Glauben Landskron , Ilan Camhi-Vainroj , Benjamín Basterrechea , Daniela Parada-Venegas , LOBOS GONZALEZ, LORENA DE LOURDES , Karen Dubois-Camacho , Catalina Araneda , Camila Romero , Antonia Domínguez , Gonzalo Vásquez , Francisco López-K , Karin Alvarez , Carlos M. González , Carolina Hager Ribeiro , Elisa Balboa , Eliseo Eugenin , Marcela A. Hermoso , Marjorie De la Fuente López

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Inactivated Vaccine-Induced SARS-CoV-2 Variant-Specific Immunity in Children

2022 , Jorge A. Soto , Felipe Melo-González , Cristián Gutierrez-Vera , Bárbara M. Schultz , Roslye V. Berríos-Rojas , Daniela Rivera-Pérez , Alejandro Piña-Iturbe , Guillermo Hoppe-Elsholz , Luisa F. Duarte , Yaneisi Vázquez , Daniela Moreno-Tapia , Mariana Ríos , Pablo A. Palacios , Richard Garcia-Betancourt , Álvaro Santibañez , Gaspar A. Pacheco , Constanza Mendez , Catalina A. Andrade , Pedro H. Silva , Benjamín Diethelm-Varela , Patricio Astudillo , Mario Calvo , Antonio Cárdenas , Marcela González , Macarena Goldsack , Valentina Gutiérrez , Marcela Potin , SCHILLING REDLICH, ANDREA INGRID , Lorena I. Tapia , Loreto Twele , Rodolfo Villena , Alba Grifoni , Alessandro Sette , Daniela Weiskopf , Rodrigo A. Fasce , Jorge Fernández , Judith Mora , Eugenio Ramírez , Aracelly Gaete-Argel , Mónica L. Acevedo , Fernando Valiente-Echeverría , Ricardo Soto-Rifo , Angello Retamal-Díaz , Nathalia Muñoz-Jofré , Xing Meng , Qianqian Xin , Eduardo Alarcón-Bustamante , José V. González-Aramundiz , Nicole Le Corre , María Javiera Álvarez-Figueroa , CEA GONZALEZ, PABLO ANTONIO , Katia Abarca , Cecilia Perret , Leandro J. Carreño , Susan M. Bueno , Alexis M. Kalergis , Patricio Astudillo Paredes , Epifanía Hernández Jara , Héctor Morán Fernández , Javiera Arenas Urra , Stephani Ascui Baeza , María Olivia Cabrera , José Romero Muñoz , Gonzalo Alarcón Andrade , Rocío Rodríguez Espósito , Anwar Gutiérrez Silva , Fernanda Pérez Gutiérrez , Alma Muñoz Muñoz , Marcela Potin Santander , Sofia López , Tania Weil , Macarena Goldsack , Deidyland Arenas , Javiera Moore , ARAYA CASTRO, PAULINA ANDREA , Lorena Pilicita , Vania Valenzuela , Catalina Campos , Mauricio Soto , SCHILLING REDLICH, ANDREA INGRID , Alberto Trautmann , Ana Fritis , Daniela Pavez , Javiera Arancibia , Lilian Rubio , Paula Viviani , Vinka Basic , Cassandra Cárcamo , Mario Calvo Gil , Marisol Wenzel , Nicole Carey , Roberto Burgos , Loreto Twele , Daniel Beltrán , Silvana Grandón , Carlos Tovar , Marcela González , Daniela Fuentes , Teresa Ramírez , Mariela Cepeda Corrales , Nataly Martínez López , Valentina Gutiérrez , Felipe Reyes , Armando Lavayen , Melissa González , Monserrat Gutiérrez , Noris Rengifo , Carla Ortega , Florencia Saver , Lorena Tapia , Mirta Acuña , Javiera Albornoz , Tania Cariqueo , Alejandro Velásquez , Yennybeth Leiva Chamorro , Rodolfo Villena , Paola Flores , Francisca Bartsch , Belén Sepúlveda , Daniela Garmendia , Antonio Cárdenas , Angello Retamal , Carmen Ludeña , Lorena González , Carolina Hermosilla , Gustavo Keilhold , Francisco Cammarata-Scalisi , Jessica Álvarez , Jessica Romero , Pía Villarroel , Francisca Muñoz , Jorge Maya , Andrés Canales , Margarita K. Lay , Christian Muñoz , Roylester Araya , Kanta Subbarao

This work evaluated the immune response induced by two doses of CoronaVac separated by 4 weeks in healthy children and adolescents in Chile. To date, few studies have described the effects of CoronaVac in the pediatric population.

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Exposure to the pro-inflammatory prostaglandin E2 disrupts E-cadherin/Caveolin1-mediated tumor suppression to favor Caveolin-1 enhanced migration, invasion and metastasis of melanoma cells

2022 , LOBOS GONZALEZ, LORENA DE LOURDES , FARFÁN BECERRA, NICOLE , SILVA, V.

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Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors

2019 , Christopher Fitzpatrick , Maximiliano F. Bendek , Macarena Briones , Nicole Farfán , Valeria A. Silva , Gino Nardocci , Martín Montecino , Anne Boland , Jean-François Deleuze , Jaime Villegas , Claudio Villota , Verónica Silva , LOBOS GONZALEZ, LORENA DE LOURDES , Vincenzo Borgna , Eric Barrey , Luis O. Burzio , Verónica A. Burzio

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Gold nanoparticles as tracking devices to shed light on the role of caveolin-1 in early stages of melanoma metastasis

2018 , Simón Guerrero , Victor Manuel Díaz-García , Pamela Contreras-Orellana , Pablo Lara , Sujey Palma , Fanny Guzman , LOBOS GONZALEZ, LORENA DE LOURDES , Areli Cárdenas , Ximena Rojas-Silva , Luis Muñoz , Lisette Leyton , Marcelo J Kogan , Andrew FG Quest

Aim: To track early events during lung metastasis, we labeled cells expressing (B16F10CAV1) or lacking CAV1 (B16F10mock) with gold nanoparticles conjugated to the peptide TAT (AuNPs-PEG-TAT). Methods: B16F10 expressing or lacking CAV1 were labeled with AuNPs-PEG-TAT. The physicochemical properties and cytotoxicity of these nanoparticles, as well as their effects on migration and invasiveness of B16F10 cells in vitro were evaluated. Ex vivo lung distribution of the labeled cells after tail vein injection into C57BL/6 mice was examined. Results: AuNPs-PEG-TAT did not affect B16F10 viability, migration and invasiveness. The metastatic and tumorigenic capability of the labeled B16F10 was also not modified in comparison to unlabeled B16F10 cells. CAV1 expression favored the retention of B16F10 cells in the lungs of mice 2 h post injection, suggesting CAV1 promoted adherence to endothelial cells and transendothelial migration. Conclusions: We developed a protocol to label B16F10 cells with AuNPs-PEG-TAT that permits subsequent tracking of cells in mice. CAV1 overexpression was found to increase retention and transendothelial migration of B16F10 cells in the lung.

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