LOBOS GONZALEZ, LORENA DE LOURDES
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LOBOS GONZALEZ, LORENA DE LOURDES
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llobos@udd.cl
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28767817600

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90 Role of microrna-145 in epithelial ovarian cancer

2020 , Carmen Romero , Maritza P Garrido , Ignacio Torres , Andrea Hernandez , Jonas Chnaiderman , Margarita Vega , Alberto Selman , Jessica Preisler , LOBOS GONZALEZ, LORENA DE LOURDES

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Inhibition of PORCN Blocks Wnt Signaling to Attenuate Progression of Oral Carcinogenesis

2023 , Daniel Peña-Oyarzún , Tania Flores , Vicente A. Torres , Andrew F.G. Quest , LOBOS GONZALEZ, LORENA DE LOURDES , Catalina Kretschmar , Pamela Contreras , Andrea Maturana-Ramírez , Alfredo Criollo , Montserrat Reyes

Oral squamous cell carcinoma (OSCC) is commonly preceded by potentially malignant lesions, referred to as oral dysplasia. We recently reported that oral dysplasia is associated with aberrant activation of the Wnt/β-catenin pathway, due to overexpression of Wnt ligands in a Porcupine (PORCN)-dependent manner. Pharmacologic inhibition of PORCN precludes Wnt secretion and has been proposed as a potential therapeutic approach to treat established cancers. Nevertheless, there are no studies that explore the effects of PORCN inhibition at the different stages of oral carcinogenesis.

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Exposure to the pro-inflammatory prostaglandin E2 disrupts E-cadherin/Caveolin1-mediated tumor suppression to favor Caveolin-1 enhanced migration, invasion and metastasis of melanoma cells

2022 , LOBOS GONZALEZ, LORENA DE LOURDES , FARFÁN BECERRA, NICOLE , SILVA, V.

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Pannexin-1 expression in tumor cells correlates with colon cancer progression and survival

2024 , Aaron Fierro-Arenas , Glauben Landskron , Ilan Camhi-Vainroj , Benjamín Basterrechea , Daniela Parada-Venegas , LOBOS GONZALEZ, LORENA DE LOURDES , Karen Dubois-Camacho , Catalina Araneda , Camila Romero , Antonia Domínguez , Gonzalo Vásquez , Francisco López-K , Karin Alvarez , Carlos M. González , Carolina Hager Ribeiro , Elisa Balboa , Eliseo Eugenin , Marcela A. Hermoso , Marjorie De la Fuente López

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Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors

2019 , Christopher Fitzpatrick , Maximiliano F. Bendek , Macarena Briones , Nicole Farfán , Valeria A. Silva , Gino Nardocci , Martín Montecino , Anne Boland , Jean-François Deleuze , Jaime Villegas , Claudio Villota , Verónica Silva , LOBOS GONZALEZ, LORENA DE LOURDES , Vincenzo Borgna , Eric Barrey , Luis O. Burzio , Verónica A. Burzio

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Dataset 1 - Lactadherin: From a Well-Known Breast Tumor Marker to a Possible Player in Extracellular Vesicle-Mediated Cancer Progression

2022 , LOBOS GONZALEZ, LORENA DE LOURDES , EDUARDO FELIPE DURÁN JARA

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Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat

2016 , Amalia Sapag , Thergiory Irrazábal , LOBOS GONZALEZ, LORENA DE LOURDES , Carlos R Muñoz-Brauning , María Elena Quintanilla , Lutske Tampier

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Dataset 2 - Lactadherin: From a Well-Known Breast Tumor Marker to a Possible Player in Extracellular Vesicle-Mediated Cancer Progression

2022 , LOBOS GONZALEZ, LORENA DE LOURDES , EDUARDO FELIPE DURÁN JARA

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Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines

2018 , America Campos , Carlos Salomon , Rocio Bustos , Jorge Díaz , Samuel Martínez , Veronica Silva , Constanza Reyes , Natalia Díaz-Valdivia , Manuel Varas-Godoy , LOBOS GONZALEZ, LORENA DE LOURDES , Andrew FG Quest

Breast cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths in women worldwide, whereby mortality is largely attributable to the development of distant metastasis. Caveolin-1 (CAV1) is a multifunctional membrane protein that is typically upregulated in the final stages of cancer and promotes migration and invasion of tumor cells. Elevated levels of CAV1 have been detected in extracellular vesicles (EVs) from advanced cancer patients. EVs are lipid enclosed vesicular structures that contain bioactive proteins, DNA and RNAs, which can be transferred to other cells and promote metastasis. Therefore, we hypothesized that CAV1 containing EVs released from breast cancer cells may enhance migration and invasion of recipient cells. EVs were purified from conditioned media of MDA-MB-231 wild-type (WT), MDA-MB-231 (shCAV1; possessing the plasmid pLKO.1 encoding a ‘small hairpin’ directed against CAV1) and MDA-MB-231 (shC) short hairpin control cells. Nanoparticle tracking analysis revealed an average particle size of 40–350 nm for all preparations. As anticipated, CAV1 was detected in MDA-MB-231 WT and shC EVs, but not in MDA-MB-231 (shCAV1) EVs. Mass spectrometry analysis revealed the presence of specific cell adhesion-related proteins, such as Cyr61, tenascin (TNC) and S100A9 only in WT and shC, but not in shCAV1 EVs. Importantly, EVs containing CAV1 promoted migration and invasion of cells lacking CAV1. We conclude that the presence of CAV1 in EVs from metastatic breast cancer cells is associated with enhanced migration and invasiveness of recipient cells in vitro, suggesting that intercellular communication promoted by EVs containing CAV1 will likely favor metastasis in vivo.

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Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging

2018 , Victor Manuel Díaz-García , Simón Guerrero , Natalia Díaz-Valdivia , LOBOS GONZALEZ, LORENA DE LOURDES , Marcelo Kogan , José Pérez-Donoso , Andrew F.G. Quest

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