Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors

Journal
Cell Death & Disease
ISSN
2041-4889
Date Issued
2019
Author(s)
Christopher Fitzpatrick
Maximiliano F. Bendek
Macarena Briones
Nicole Farfán
Valeria A. Silva
Gino Nardocci
Martín Montecino
Anne Boland
Jean-François Deleuze
Jaime Villegas
Claudio Villota
Verónica Silva
Vincenzo Borgna
Eric Barrey
Luis O. Burzio
Verónica A. Burzio
Type
Resource Types::text::journal::journal article
Scopus ID
2-s2.0-85067064253
WoS ID
WOS:000470936100005
DOI
URL
Cite this document
Fitzpatrick, C., Bendek, M. F., Briones, M., Farfán, N., Silva, V. A., Nardocci, G., Montecino, M., Boland, A., Deleuze, J.-F., Villegas, J., Villota, C., Silva, V., Lobos-Gonzalez, L., Borgna, V., Barrey, E., Burzio, L. O., & Burzio, V. A. (2019). Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors. Cell Death & Disease, 10(6), 423. https://doi.org/10.1038/s41419-019-1649-3
Subjects
long noncoding rnas

; 

microrna-binding-sites

; 

messenger-rnas

; 

expression

; 

survivin

; 

asncmtrna-2

; 

regulator

; 

5'-utr

; 

cdk1

; 

animals

; 

antagomirs

; 

apoptosis

; 

breast neoplasms

; 

cdc2 protein kinase

; 

cell cycle checkpoints

; 

cell line, tumor

; 

cell proliferation

; 

cyclin b1

; 

cyclin d1

; 

down-regulation

; 

female

; 

humans

; 

mice

; 

mice, inbred balb c

; 

micrornas

; 

mitochondria

; 

rna interference

; 

rna, long noncoding

; 

rna, small interfering

; 

andes 1537

; 

antineoplastic agent

; 

antisense oligonucleotide

; 

cell cycle protein

; 

cyclin b1

; 

cyclin d1

; 

mitochondrial rna

; 

survivin

; 

unclassified drug

; 

untranslated rna

; 

antagomir

; 

cdk1 protein, human

; 

cyclin b1

; 

cyclin d1

; 

cyclin dependent kinase 1

; 

long untranslated rna

; 

microrna

; 

small interfering rna

; 

animal experiment

; 

animal model

; 

antineoplastic activity

; 

apoptosis

; 

article

; 

breast cancer

; 

breast cancer cell line

; 

cancer inhibition

; 

cell cycle arrest

; 

cell cycle progression

; 

cell proliferation

; 

comparative study

; 

controlled study

; 

dna fragmentation

; 

down regulation

; 

genetic transfection

; 

human

; 

human cell

; 

in vivo study

; 

mda-mb-231 cell line

; 

mouse

; 

nonhuman

; 

priority journal

; 

protein expression

; 

rna sequence

; 

tumor cell

; 

tumor growth

; 

tumor xenograft

; 

upregulation

; 

western blotting

; 

zr-75-1 cell line

; 

animal

; 

apoptosis

; 

bagg albino mouse

; 

breast tumor

; 

cell cycle checkpoint

; 

chemistry

; 

female

; 

genetics

; 

metabolism

; 

mitochondrion

; 

pathology

; 

rna interference

; 

tumor cell line