ARAYA CASTRO, PAULINA ANDREA
Preferred name
ARAYA CASTRO, PAULINA ANDREA
Main Affiliation
Email
paraya@udd.cl
ORCID
0000-0003-1274-2792
Scopus Author ID
57194510079
14 results
Now showing 1 - 10 of 14
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Item type:Publication, Pelvic Floor Physiotherapy and its Research Development in the Continuum of Gynecological, Prostate, and Colorectal Cancer Care(Springer International Publishing, 2024); ; ;Fabiana Flores Sperandio ;Kamilla ZomkowskiDiego Dantas24 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Physical function and symptoms in adult hematopoietic stem cell transplantation patients, by severity of oral mucositis: a prospective study(Springer Science and Business Media LLC, 2025-06-27) ;Tomas López-Espinoza; ;Lizette Gutiérrez-Silva ;Mónica Peña-EspinozaPaola Roldán3Scopus© Citations 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 5Scopus© Citations 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CRISPR/Cas13-Based Platforms for a Potential Next-Generation Diagnosis of Colorectal Cancer through Exosomes Micro-RNA Detection: A Review(2021) ;BenjamĂn Durán-Vinet ;Karla Araya-Castro; ;Luis VergaraHelga Weber<jats:p>Colorectal cancer (CRC) is the third most prevalent cancer with the second highest mortality rate worldwide. CRC is a heterogenous disease with multiple risk factors associated, including obesity, smoking, and use of alcohol. Of total CRC cases, 60% are diagnosed in late stages, where survival can drop to about 10%. CRC screening programs are based primarily on colonoscopy, yet this approach is invasive and has low patient adherence. Therefore, there is a strong incentive for developing molecular-based methods that are minimally invasive and have higher patient adherence. Recent reports have highlighted the importance of extracellular vesicles (EVs), specifically exosomes, as intercellular communication vehicles with a broad cargo, including micro-RNAs (miRNAs). These have been syndicated as robust candidates for diagnosis, primarily for their known activities in cancer cells, including immunoevasion, tumor progression, and angiogenesis, whereas miRNAs are dysregulated by cancer cells and delivered by cancer-derived exosomes (CEx). Quantitative polymerase chain reaction (qPCR) has shown good results detecting specific cancer-derived exosome micro-RNAs (CEx-miRNAs) associated with CRC, but qPCR also has several challenges, including portability and sensitivity/specificity issues regarding experiment design and sample quality. CRISPR/Cas-based platforms have been presented as cost-effective, ultrasensitive, specific, and robust clinical detection tools in the presence of potential inhibitors and capable of delivering quantitative and qualitative real-time data for enhanced decision-making to healthcare teams. Thereby, CRISPR/Cas13-based technologies have become a potential strategy for early CRC diagnosis detecting CEx-miRNAs. Moreover, CRISPR/Cas13-based platforms’ ease of use, scalability, and portability also showcase them as a potential point-of-care (POC) technology for CRC early diagnosis. This study presents two potential CRISPR/Cas13-based methodologies with a proposed panel consisting of four CEx-miRNAs, including miR-126, miR-1290, miR-23a, and miR-940, to streamline novel applications which may deliver a potential early diagnosis and prognosis of CRC.</jats:p>7Scopus© Citations 30 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Photobiomodulation therapy to prevent oral mucositis and functional impairment in adult patients with haematological cancer undergoing haematopoietic stem cell transplantation: randomised trial protocol(2024) ;Tomas LĂłpez-Espinoza; ; ; Paola Roldán<jats:sec><jats:title>Introduction</jats:title><jats:p>Oral mucositis is a highly prevalent condition in individuals treated for haematological neoplasms, primarily during haematopoietic stem cell transplantation (HSCT). The condition is known to delay recovery processes, increasing the risk of infection, the number of interventions and the length of hospital stays. The proposed Photobiomodulation Therapy for Oral Mucositis and Functional Impairment Transplantation Trial aims to assess the effectiveness and acceptability of using photobiomodulation in the oral cavity to prevent oral mucositis and functional impairment in adult patients undergoing HSCT.</jats:p></jats:sec><jats:sec><jats:title>Methods and analysis</jats:title><jats:p>This is an assessor-blinded and statistician-blinded, parallel-group randomised controlled clinical trial (photobiomodulation vs control group). Participants and setting: 30 patients, aged 18–65 years, with haematological neoplasms undergoing HSCT at the ClĂnica Dávila Oncology and Bone Marrow Transplant Unit. Primary outcome measures: oral mucositis will be assessed daily using the WHO grading scale, beginning on the day of transplant through day 20 post-transplant. Researchers will assess functional capacity using a 2 min step test, handgrip strength with the Jamar digital dynamometer, lower limb strength using a 30’ sit-to-stand test and quality of life with the Functional Assessment of Cancer Therapy-Bone Marrow Transplantation Questionnaire. Acceptability will be assessed by logging treatment adherence and using a Visual Analogue Scale. Assessments will occur at two time points (1): on admission to the transplant unit, before starting the conditioning regimen and (2) on the day of discharge. Intervention: three times per week photobiomodulation therapy using a diode laser device will begin the first day of conditioning and continue through day 3 post-transplant.</jats:p></jats:sec><jats:sec><jats:title>Ethics and dissemination</jats:title><jats:p>The ClĂnica Dávila and Universidad del Desarrollo Clinical Research Ethics Committees approved this study in accordance with the Helsinki Declaration. Patients’ informed consent will be required. The dissemination strategy includes publication in scientific journals as well as presentations in the media and at conferences.</jats:p></jats:sec><jats:sec><jats:title>Trial registration number</jats:title><jats:p><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="clintrialgov" xlink:href="NCT06260111">NCT06260111</jats:ext-link>.</jats:p></jats:sec>2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pre-rehabilitation of the pelvic floor before radiation therapy for cervical cancer: a pilot study(2020); ; ;Paulette Diaz-Guerrero ;Ingrid Alanis FerradaAngĂ©lica Claudia MartĂnez-Varas1 2Scopus© Citations 23 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, From treatment to return to work in chilean breast cancer survivors: a qualitative study(Springer Science and Business Media LLC, 2025-10-23) ;Alejandra AlcaĂno-Morales ;Cristina Sade-Botto ;SebastiĂ©n SepĂşlveda-Soto; 1Scopus© Citations 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, AdaptaciĂłn y validaciĂłn de las escalas de autoeficacia y expectativa de resultados para la práctica de ejercicios de suelo pĂ©lvico en mujeres con cáncer ginecolĂłgico(2020); ;M.J. Calero GarcĂa ;C. Sacomori ;P. Diaz-GuerreroA.C. MartĂnez-Varas2Scopus© Citations 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Barriers to and facilitators of adherence to pelvic floor muscle exercises and vaginal dilator use among gynecologic cancer patients: a qualitative study(2022); ;Sonia Roa-Alcaino ;Claudia Celedón ;Mónica Cuevas-SaidDiego de Sousa Dantas1 1Scopus© Citations 10