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    Validación del cuestionario EORTC QLQ -CR29 para evaluación de la calidad de vida relacionada a la salud de personas adultas con cáncer colorrectal en Chile
    (2024)
    Luz Alejandra Lorca Parraguez
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    ;
    Marta Pizarro
    ;
    Ivana Leao Ribeiro
    ;
    Rodrigo Vidal
    <jats:p>IntroducciĂłn: Personas con cáncer colorrectal (CCR) pueden presentar efectos adversos, perjudicando la calidad de vida relacionada a la salud (CVRS).Objetivo: Validar el mĂłdulo QLQ CR2-9 para evaluaciĂłn de la CVRS, en Chile. Materiales y mĂ©todo: Estudio transversal que incluyĂł 170 personas con CCR. Se analizaron la consistencia interna y validez de constructo del instrumento con test de hipĂłtesis.Resultados: 117 personas (68,8%) fueron evaluadas antes de la cirugĂ­a y 53 (31,2%) despuĂ©s de la cirugĂ­a. La consistencia interna del QLQ CR-29 fue α=0,838. Fueron comprobadas las hipĂłtesis planteadas: Los pacientes evaluados antes de la cirugĂ­a se quejaron más de “sangre/mucosidad en las heces”, “dolor abdominal”, “pĂ©rdida de cabello” e “hinchazĂłn abdominal”, mientras que los pacientes evaluados despuĂ©s presentaron más “incontinencia fecal” (p&lt;0,05). Antes de la cirugĂ­a, los pacientes con CCR presentaron mayores valores de “frecuencia urinaria”, “frecuencia de deposiciones”, “dolor en las nalgas”, “problemas con el gusto” y “vergĂĽenza”; mientras que aquellos con cáncer de colon que se quejaban más de “sangre/mucosidad en las heces” (p&lt;0,05). DespuĂ©s de la cirugĂ­a, los pacientes con cáncer de recto tenĂ­an mayor “frecuencia de deposiciones”, “eliminaciĂłn de gases” y “vergĂĽenza” (p=0,004) en comparaciĂłn con los con cáncer de colon (p&lt;0,05). Los pacientes ostomizados presentaron más “incontinencia fecal” y “vergĂĽenza” (p&lt;0,001). Fueron observadas correlaciones positivas y negativas bajas entre la mayorĂ­a de las dimensiones del QLQ C-29 con las dimensiones del QLQ C-30. ConclusiĂłn: La versiĂłn chilena del mĂłdulo QLQ CR-29 es adecuada para evaluar la CVRS en personas con CCR. </jats:p>
      1Scopus© Citations 1
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    Psychometric properties of the Chilean version of the quality of life questionnaire for multiple myeloma
    (2024)
    Luz Alejandra Lorca
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    ;
    Camila Peña
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    Claudia Barrera
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    Melissa Salazar
    <jats:p>ABSTRACT Objectives: To evaluate the internal consistency and construct validity of the QLQ-MY20 for assessing the quality of life in multiple myeloma survivors in Chile. Methods: This was a cross-sectional study conducted between March 2020 and December 2022. It involved 118 individuals from two public hospitals. The QLQ-C30 and QLQ-MY20 questionnaires were used. Internal consistency was assessed using Cronbach’s alpha(α), and construct validity was evaluated through hypothesis testing (Mann-Whitney and Spearman correlation). Results: The average age of participants was 67.2 years (SD=9.2). Internal consistency for the complete scale was α=0.779, for the “disease symptoms” dimension α=0.671, for the “side effects of treatments” dimension α=0.538, and for the “future perspective” dimension α=0.670. Four of the five construct validity hypotheses were confirmed: women, individuals with worse performance status, those with pain, and those with worse fatigue showed more symptoms. Conclusions: The Chilean version of the QLQ-MY20 demonstrates adequate internal consistency and construct validity.</jats:p>
      1Scopus© Citations 3
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      1  2Scopus© Citations 20
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    Physical function and symptoms in adult hematopoietic stem cell transplantation patients, by severity of oral mucositis: a prospective study
    (Springer Science and Business Media LLC, 2025-06-27)
    Tomas LĂłpez-Espinoza
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    ;
    Lizette Gutiérrez-Silva
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    Mónica Peña-Espinoza
    ;
    Paola Roldán
      3Scopus© Citations 1
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    The effectiveness of different electrical nerve stimulation protocols for treating adults with non-neurogenic overactive bladder: a systematic review and meta-analysis
    (2022)
    Kamilla Zomkowski
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    Ingridy Kammers
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    Bruna Baungarten Hugen Back
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    Géssica Maria Moreira
    ;
    Anelise Sonza
      1  5Scopus© Citations 12
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    Pre-rehabilitation of the pelvic floor before radiation therapy for cervical cancer: a pilot study
    (2020) ; ;
    Paulette Diaz-Guerrero
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    Ingrid Alanis Ferrada
    ;
    Angélica Claudia Martínez-Varas
      1  2Scopus© Citations 23
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    Photobiomodulation therapy to prevent oral mucositis and functional impairment in adult patients with haematological cancer undergoing haematopoietic stem cell transplantation: randomised trial protocol
    (2024)
    Tomas LĂłpez-Espinoza
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    ; ; ;
    Paola Roldán
    <jats:sec><jats:title>Introduction</jats:title><jats:p>Oral mucositis is a highly prevalent condition in individuals treated for haematological neoplasms, primarily during haematopoietic stem cell transplantation (HSCT). The condition is known to delay recovery processes, increasing the risk of infection, the number of interventions and the length of hospital stays. The proposed Photobiomodulation Therapy for Oral Mucositis and Functional Impairment Transplantation Trial aims to assess the effectiveness and acceptability of using photobiomodulation in the oral cavity to prevent oral mucositis and functional impairment in adult patients undergoing HSCT.</jats:p></jats:sec><jats:sec><jats:title>Methods and analysis</jats:title><jats:p>This is an assessor-blinded and statistician-blinded, parallel-group randomised controlled clinical trial (photobiomodulation vs control group). Participants and setting: 30 patients, aged 18–65 years, with haematological neoplasms undergoing HSCT at the Clínica Dávila Oncology and Bone Marrow Transplant Unit. Primary outcome measures: oral mucositis will be assessed daily using the WHO grading scale, beginning on the day of transplant through day 20 post-transplant. Researchers will assess functional capacity using a 2 min step test, handgrip strength with the Jamar digital dynamometer, lower limb strength using a 30’ sit-to-stand test and quality of life with the Functional Assessment of Cancer Therapy-Bone Marrow Transplantation Questionnaire. Acceptability will be assessed by logging treatment adherence and using a Visual Analogue Scale. Assessments will occur at two time points (1): on admission to the transplant unit, before starting the conditioning regimen and (2) on the day of discharge. Intervention: three times per week photobiomodulation therapy using a diode laser device will begin the first day of conditioning and continue through day 3 post-transplant.</jats:p></jats:sec><jats:sec><jats:title>Ethics and dissemination</jats:title><jats:p>The Clínica Dávila and Universidad del Desarrollo Clinical Research Ethics Committees approved this study in accordance with the Helsinki Declaration. Patients’ informed consent will be required. The dissemination strategy includes publication in scientific journals as well as presentations in the media and at conferences.</jats:p></jats:sec><jats:sec><jats:title>Trial registration number</jats:title><jats:p><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="clintrialgov" xlink:href="NCT06260111">NCT06260111</jats:ext-link>.</jats:p></jats:sec>
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