CRIS

Permanent URI for this communityhttps://investigadores.udd.cl/handle/123456789/1

Browse

Settings

Subject: search.filters.subject.differentiation

Search Results

Now showing 1 - 5 of 5
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Renal angiomyolipomas: Typical and atypical features on computed tomography and magnetic resonance imaging
    (Baishideng Publishing Group Inc., 2025-02-28)
    LABRA WEITZLER, ANDRES ANTONIO  
    ;
    SCHIAPPACASSE FAUNDES, GIANCARLO  
    ;
    Diego Constenla
    ;
    Joaquin Cristi
    <jats:p>Angiomyolipomas (AMLs) represent the most common benign solid renal tumors. The frequency of their detection in the general population is increasing owing to advances in imaging technology. The objective of this review is to discuss computed tomography (CT) and magnetic resonance imaging findings for both typical and atypical renal AMLs, along with their associated complications. AMLs are typically defined as solid triphasic tumors composed of varying amounts of dysmorphic and tortuous blood vessels, smooth muscle components and adipose tissue. In an adult, a classical renal AML appears as a solid, heterogeneous renal cortical mass with macroscopic fat. However, up to 5% of AMLs contain minimal fat and cannot be reliably diagnosed by imaging. Fat-poor AMLs can appear as hyperattenuating masses on unenhanced CT and as hypointense masses on T2WI; other AMLs may be isodense or exhibit cystic components. Hemorrhage is the most common complication, and AMLs with hemorrhage can mimic other tumors, making their diagnosis challenging. Understanding the variable and heterogeneous nature of this neoplasm to correctly classify renal AMLs and to avoid misdiagnosis of other renal lesions is crucial.</jats:p>
      4
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    The amniotic fluid as a source of mesenchymal stem cells with lung‐specific characteristics
    (2017)
    Flore Lesage
    ;
    Silvia Zia
    ;
    JIMENEZ GREZ, JULIO ALBERTO  
    ;
    Jan Deprest
    ;
    Jaan Toelen
    <jats:p>What is already known about this topic? <jats:list list-type="bullet"> <jats:list-item><jats:p>Fetal tissues are interesting sources of stem cells for autologous therapy in a neonatal context.</jats:p></jats:list-item> <jats:list-item><jats:p>AF‐MSC are a heterogeneous stem cell population of which the exact origin remains elusive.</jats:p></jats:list-item> </jats:list></jats:p><jats:p>What does this study add? <jats:list list-type="bullet"> <jats:list-item><jats:p>This study identifies AF‐MSC with lung‐specific characteristics.</jats:p></jats:list-item> <jats:list-item><jats:p>This study provides a reliable culture method that supports the expansion of lung‐specific AF‐MSC.</jats:p></jats:list-item> </jats:list></jats:p>
      8Scopus© Citations 6
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Differences in cortical processing of facial emotions in broader autism phenotype
    (2022)
    SOTO ICAZA, PATRICIA  
    ;
    Brice Beffara-Bret
    ;
    Lorena Vargas
    ;
    Francisco Aboitiz
    ;
    BILLEKE BOBADILLA, PABLO ERNESTO  
    <jats:p>Autism Spectrum Disorder (ASD) is a heterogeneous condition that affects face perception. Evidence shows that there are differences in face perception associated with the processing of low spatial frequency (LSF) and high spatial frequency (HSF) of visual stimuli between non-symptomatic relatives of individuals with autism (broader autism phenotype, BAP) and typically developing individuals. However, the neural mechanisms involved in these differences are not fully understood. Here we tested whether face-sensitive event related potentials could serve as neuronal markers of differential spatial frequency processing, and whether these potentials could differentiate non-symptomatic parents of children with autism (pASD) from parents of typically developing children (pTD). To this end, we performed electroencephalographic recordings of both groups of parents while they had to recognize emotions of face pictures composed of the same or different emotions (happiness or anger) presented in different spatial frequencies. We found no significant differences in the accuracy between groups but lower amplitude modulation in the Late Positive Potential activity in pASD. Source analysis showed a difference in the right posterior part of the superior temporal region that correlated with ASD symptomatology of the child. These results reveal differences in brain processing of recognition of facial emotion in BAP that could be a precursor of ASD.</jats:p>
      2Scopus© Citations 6
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
      5Scopus© Citations 106
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes
    (2016)
    FLAVIA ALEJANDRA BRUNA
    ;
    CONTADOR MARTINEZ, DAVID ERNESTO  
    ;
    CONGET MOLINA, PAULETTE ANDREA  
    ;
    Benjamín Erranz
    ;
    Claudia L. Sossa
    <jats:p>Preclinical and clinical studies have shown that a therapeutic effect results from mesenchymal stromal cells (MSCs) transplant. No systematic information is currently available regarding whether donor age modifies MSC regenerative potential on cutaneous wound healing. Here, we evaluate whether donor age influences this potential. Two different doses of bone marrow MSCs (BM-MSCs) from young, adult, or old mouse donors or two doses of their acellular derivatives mesenchymal stromal cells (acd-MSCs) were intradermally injected around wounds in the midline of C57BL/6 mice. Every two days, wound healing was macroscopically assessed (wound closure) and microscopically assessed (reepithelialization, dermal-epidermal junction, skin appendage regeneration, granulation tissue, leukocyte infiltration, and density dermal collagen fibers) after 12 days from MSC transplant. Significant differences in the wound closure kinetic, quality, and healing of skin regenerated were observed in lesions which received BM-MSCs from different ages or their acd-MSCs compared to lesions which received vehicle. Nevertheless, our data shows that adult’s BM-MSCs or their acd-MSCs were the most efficient for recovery of most parameters analyzed. Our data suggest that MSC efficacy was negatively affected by donor age, where the treatment with adult’s BM-MSCs or their acd-MSCs in cutaneous wound promotes a better tissue repair/regeneration. This is due to their paracrine factors secretion.</jats:p>
      1Scopus© Citations 41  1