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    Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research
    (2024)
    Karen Nuytemans
    ;
    Sanne Franzen
    ;
    Iris J. Broce
    ;
    Paulo Caramelli
    ;
    Ratnavalli Ellajosyula
    <jats:title>Abstract</jats:title><jats:p>Frontotemporal dementia (FTD) is one of the leading causes of young‐onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross‐cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.</jats:p>
    Scopus© Citations 4
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    Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities–focused research
    (2023)
    Sanne Franzen
    ;
    Karen Nuytemans
    ;
    Renelle Bourdage
    ;
    Paulo Caramelli
    ;
    Ratnavalli Ellajosyula
    <jats:title>Abstract</jats:title><jats:p>Frontotemporal dementia (FTD) is one of the leading causes of dementia before age 65 and often manifests as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). FTD's exact clinical presentation varies by culture, language, education, social norms, and other socioeconomic factors; current research and clinical practice, however, is mainly based on studies conducted in North America and Western Europe. Changes in diagnostic criteria and procedures as well as new or adapted cognitive tests are likely needed to take into consideration global diversity. This perspective paper by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment examines how increasing global diversity impacts the clinical presentation, screening, assessment, and diagnosis of FTD and its treatment and care. It subsequently provides recommendations to address immediate needs to advance global FTD research and clinical practice.</jats:p>
      27Scopus© Citations 12
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      9Scopus© Citations 8
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    Scopus© Citations 7  1
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    Rol del facilitador intercultural para migrantes internacionales en centros de salud chilenos: perspectivas de cuatro grupos de actores clave
    (2019)
    Camila Sepúlveda
    ;
    CABIESES VALDES, BALTICA BEATRIZ  
    <jats:p>Objetivo. Indagar la percepción de distintos actores clave en torno al rol de facilitadores interculturales en la atención de salud a personas migrantes haitianas en las comunas de Quilicura y Santiago de Chile. Materiales y métodos. Estudio cualitativo de tipo exploratorio y descriptivo,  con diseño de estudio de caso, en centros de salud familiar y hospitales de dos comunas de la Región Metropolitana de Chile. Se utilizó la técnica de entrevistas semiestructuradas a actores claves (autoridades sanitarias, trabajadores de salud, facilitadores interculturales y migrantes internacionales), con transcripción verbatim y análisis temático de contenidos (n=18). Resultados. La percepción del rol de los facilitadores interculturales para la atención de salud de migrantes internacionales está relacionada con funciones en traducción, interpretación, educación del sistema sanitario en Chile, mediación intercultural y labores administrativas. Además, colabora en actividades educativas para migrantes que requieren apoyo con el abordaje de diferencias culturales. Esta visión es compartida por diversos actores clave considerados para el estudio y concordante con la política de salud vigente. Conclusión. Los facilitadores interculturales realizan un aporte al encuentro intercultural en salud en Chile y son testigos de cómo nuestras instituciones se enfrentan a realidades diversas en materia lingüística como sociocultural. Reconocer la importancia del facilitador intercultural en la atención sanitaria con pertinencia intercultural hacia población migrante internacional es un avance social y del sistema de salud chileno, que puede ser replicado a países que enfrentan desafíos similares y no desean ignorar la creciente diversidad social y cultural en región de América Latina y el Caribe, como consecuencia de dinámicas transformaciones de procesos de migración internacional. </jats:p>
    Scopus© Citations 14  12