Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research
Journal
Alzheimer's & Dementia
ISSN
1552-5260
1552-5279
Date Issued
2024
Author(s)
Karen Nuytemans
Sanne Franzen
Iris J. Broce
Paulo Caramelli
Ratnavalli Ellajosyula
Elizabeth Finger
Veer Gupta
Vivek Gupta
Ignacio Illán‐Gala
Samantha M. Loi
Darby Morhardt
Yolande Pijnenburg
Katya Rascovsky
Monique M. Williams
Jennifer S. Yokoyama
Juliana Acosta‐Uribe
Rufus Akinyemi
Suvarna Alladi
Biniyam A. Ayele
Yavuz Ayhan
Renelle Bourdage
Sheila Castro‐Suarez
Leonardo Cruz de Souza
Penny Dacks
Sterre C. M. de Boer
Jessica de Leon
Shana Dodge
Stephanie Grasso
Nupur Ghoshal
Vidyulata Kamath
Fiona Kumfor
Jordi A. Matias‐Guiu
Pauline Narme
T. Rune Nielsen
Daniel Okhuevbie
Stefanie Piña‐Escudero
Ramiro Ruiz‐Garcia
Brigid Ryan
Marta Scarioni
Aida Suarez‐Gonzalez
Boon Lead Tee
Elena Tsoy
Hulya Ulugut
Chiadi U. Onyike
Ganesh M. Babulal
Type
journal-article
Abstract
<jats:title>Abstract</jats:title><jats:p>Frontotemporal dementia (FTD) is one of the leading causes of young‐onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross‐cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.</jats:p>
Subjects
biomarkers
;
cultural diversity
;
epidemiology
;
ethnicity
;
frontotemporal dementia
;
genetics
;
infrastructure