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Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample
(Springer Science and Business Media LLC, 2025-03-24)
Kelly Allott
;
Walid Yassin
;
Luis Alameda
;
Tashrif Billah
;
Owen Borders
Scopus© Citations 5 7
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Cognitive function at first episode in patients subsequently developing treatment-resistant schizophrenia
(Elsevier BV, 2025-02)
Juan M. Aguirre
;
Camila Díaz Dellarossa
;
Daniella Barbagelata
;
Javiera Vásquez
;
Cristián Mena
Scopus© Citations 1 3
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Theta and alpha oscillations may underlie improved attention and working memory in musically trained children
(2024)
F. Zamorano
;
Leonie Kausel
;
BILLEKE BOBADILLA, PABLO ERNESTO
;
M. E. Sutherland
;
M. I. Alliende
<jats:title>Abstract</jats:title><jats:p><jats:bold>Introduction</jats:bold>: Attention and working memory are key cognitive functions that allow us to select and maintain information in our mind for a short time, being essential for our daily life and, in particular, for learning and academic performance. It has been shown that musical training can improve working memory performance, but it is still unclear if and how the neural mechanisms of working memory and particularly attention are implicated in this process. In this work, we aimed to identify the oscillatory signature of bimodal attention and working memory that contributes to improved working memory in musically trained children.</jats:p><jats:p><jats:bold>Materials and methods</jats:bold>: We recruited children with and without musical training and asked them to complete a bimodal (auditory/visual) attention and working memory task, whereas their brain activity was measured using electroencephalography. Behavioral, time–frequency, and source reconstruction analyses were made.</jats:p><jats:p><jats:bold>Results</jats:bold>: Results showed that, overall, musically trained children performed better on the task than children without musical training. When comparing musically trained children with children without musical training, we found modulations in the alpha band pre‐stimuli onset and the beginning of stimuli onset in the frontal and parietal regions. These correlated with correct responses to the attended modality. Moreover, during the end phase of stimuli presentation, we found modulations correlating with correct responses independent of attention condition in the theta and alpha bands, in the left frontal and right parietal regions.</jats:p><jats:p><jats:bold>Conclusions</jats:bold>: These results suggest that musically trained children have improved neuronal mechanisms for both attention allocation and memory encoding. Our results can be important for developing interventions for people with attention and working memory difficulties.</jats:p>
Scopus© Citations 2 9
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The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial
(2024)
FIGUEROA VARGAS, ALEJANDRA MABEL
;
Begoña Góngora
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María Francisca Alonso
;
Alonso Ortega
;
Patricio Soto-Fernández
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia and mild cognitive impairment (MCI). The latter can be considered a prodromal phase of some dementias and a critical stage for interventions to postpone the impairment of functionality. Working memory (WM) is a pivotal cognitive function, representing the fundamental element of executive functions. This project proposes an intervention protocol to enhance WM in these users, combining cognitive training with transcranial electrical stimulation of alternating current (tACS). This technique has been suggested to enhance the neuronal plasticity needed for cognitive processes involving oscillatory patterns. WM stands to benefit significantly from this approach, given its well-defined electrophysiological oscillations. Therefore, tACS could potentially boost WM in patients with neurodegenerative diseases.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>This study is a phase IIb randomised, double-blind clinical trial with a 3-month follow-up period. The study participants will be 62 participants diagnosed with MCI, aged over 60, from Valparaíso, Chile. Participants will receive an intervention combining twelve cognitive training sessions with tACS. Participants will receive either tACS or placebo stimulation in eight out of twelve training sessions. Sessions will occur twice weekly over 6 weeks. The primary outcomes will be electroencephalographic measurements through the prefrontal theta oscillatory activity, while the secondary effects will be cognitive assessments of WM. The participants will be evaluated before, immediately after, and 3 months after the end of the intervention.</jats:p> </jats:sec><jats:sec> <jats:title>Discussion</jats:title> <jats:p>The outcomes of this trial will add empirical evidence about the benefits and feasibility of an intervention that combines cognitive training with non-invasive brain stimulation. The objective is to contribute tools for optimal cognitive treatment in patients with MCI. To enhance WM capacity, postpone the impairment of functionality, and obtain a better quality of life.</jats:p> </jats:sec><jats:sec> <jats:title>Trial registration</jats:title> <jats:p>ClinicalTrials.gov NCT05291208. Registered on 28 February 2022. ISRCTN87597719 retrospectively registered on 15 September 2023.</jats:p> </jats:sec>
Scopus© Citations 9 4
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How right hemisphere damage after stroke can impair speech comprehension
(2018)
GAJARDO VIDAL, ANDREA ELIZABETH
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Diego L Lorca-Puls
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Thomas M H Hope
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Oiwi Parker Jones
;
Mohamed L Seghier
4Scopus© Citations 64
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Modulation of executive functioning by social stress: a behavioural study (
<i>Modulación del funcionamiento ejecutivo por estrés social: un estudio conductual</i>
)
(2023)
Barllech Romero
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CORTÉS RIVERA, CRISTIAN ANDRÉS
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CERIC GARRIDO, FRANCISCO JOSE
12
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Modulation of performance during executive function tasks by emotional salience of stimuli (Modulación del desempeño en tareas de funciones ejecutivas por saliencia emocional de los estímulos)
(2023)
CERIC GARRIDO, FRANCISCO JOSE
;
Manuel Montemurro
;
Andrés Muñoz-Nájar Pacheco
;
Cristian Cortés
Scopus© Citations 2 11
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Neural Dynamics of Improved Bimodal Attention and Working Memory in Musically Trained Children
(2020)
Leonie Kausel
;
Francisco Zamorano
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BILLEKE BOBADILLA, PABLO ERNESTO
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Mary E. Sutherland
;
LARRAIN VALENZUELA, MARIA JOSEFINA
Scopus© Citations 13 2
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Default Mode Network, Meditation, and Age-Associated Brain Changes: What Can We Learn from the Impact of Mental Training on Well-Being as a Psychotherapeutic Approach?
(2019)
Ricardo Ramírez-Barrantes
;
Marcelo Arancibia
;
Jana Stojanova
;
ASPÉ SÁNCHEZ, MAURICIO ALEJANDRO
;
Claudio Córdova
Aging is a physiological process accompanied by cognitive decline, principally in memory and executive functions. Alterations in the connectivity of the default mode network (DMN) have been found to participate in cognitive decline, as well as in several neurocognitive disorders. The DMN has antisynchronic activity with attentional networks (task-positive networks (TPN)), which are critical to executive function and memory. Findings pointing to the regulation of the DMN via activation of TPN suggest that it can be used as a strategy for neuroprotection. Meditation is a noninvasive and nonpharmacological technique proven to increase meta-awareness, a cognitive ability which involves the control of both networks. In this review, we discuss the possibility of facilitating healthy aging through the regulation of networks through meditation. We propose that by practicing specific types of meditation, cognitive decline could be slowed, promoting a healthy lifestyle, which may enhance the quality of life for the elderly.
Scopus© Citations 38 1
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Affective modulation of cognitive control: A systematic review of EEG studies
(2022)
Francisco Ahumada-Méndez
;
Boris Lucero
;
Alessio Avenanti
;
Chiara Saracini
;
María Teresa Muñoz-Quezada
Scopus© Citations 40 3

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