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    Exploring the feasibility and effectiveness of a naturalistic family centered intervention to enhance early interactions in toddlers with Down syndrome
    (Springer Science and Business Media LLC, 2025-04-09)
    Ana Mendoza-García
    ;
    Andrés Aparicio
    ;
    Paulina Sofía Arango
    ;
    TENORIO DELGADO, MARCELA  
    This study analyses the feasibility and effectiveness of BabyMICARE, a manualised intervention programme aimed at improving the interactions between caregivers and infants and toddlers with Down syndrome. The programme’s goal is to enhance caregivers’ sensitivity and reduce directivity during early interactions, particularly during play and daily routines. A pre-test and post-test design was used with 40 dyads of infants with Down syndrome and their caregivers, who were divided into a control group (n = 20) and an intervention group (n = 20), based on baseline scores in key interaction subscales. Sessions were conducted over 10 weeks by trained psychologists. Parent-infant interaction was assessed using the MACI coding system, which measures aspects such as sensitive responsiveness, directivity and the level of reciprocity between the parent and the child. The programme showed high feasibility, with a 100% attendance rate but some rescheduling. Caregivers evaluated it positively. The intervention group demonstrated significant improvements in five of eight MACI scales, particularly in sensitive responsiveness and nondirectiveness, while no changes were observed in the control group. The results suggest that BabyMICARE is a feasible and effective intervention for promoting more responsive, less directive interactions, which may be crucial in fostering children’s development.
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    Your baby has down syndrome: a reflexive thematic analysis of breaking the news to parents
    (Springer Science and Business Media LLC, 2025-05-06)
    TENORIO DELGADO, MARCELA  
    ;
    Johanna Sagner-Tapia
    ;
    Renata Garibaldi
    ;
    Vaso Totsika
    Scopus© Citations 1  6
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    Scopus© Citations 18  1
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      1Scopus© Citations 10  1
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      8  1Scopus© Citations 17
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      25  1Scopus© Citations 21
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    Attention deficit hyperactivity disorder and its association with heavy metals in children from northern Chile
    (2020)
    María Pía Muñoz
    ;
    RUBILAR RAMIREZ, PAOLA  
    ;
    Macarena Valdés
    ;
    María Teresa Muñoz-Quezada
    ;
    Andrea Gómez
      5Scopus© Citations 38
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    Interacciones entre las madres y sus bebés prematuros moderados durante la hospitalización
    (2022)
    MIRA OLIVOS, ANDREA  
    ;
    COO CALCAGNI, SOLEDAD  
    ;
    Rodolfo Bastías
    ;
    Ricardo González
    <jats:p>Los recién nacidos prematuros moderados son fisiológicamente inmaduros, su cerebro tiene que madurar y adaptarse al entorno extrauterino, lo que puede afectar su desarrollo neurológico. La interacción con sus cuidadores es crucial para su desarrollo, no obstante, estos pueden evidenciar problemáticas de salud mental como sintomatología depresiva y estrés parental. Objetivo: evaluar cómo la sintomatología depresiva y la percepción del estrés de las madres de bebés prematuros moderados durante la hospitalización puede afectar la interacción de la díada. Pacientes y Método: participaron 85 díadas. Durante la segunda y tercera semana de hospitalización, las madres completaron un cuestionario sociodemográfico, la escala de estrés parental y la Edinburgh postnatal depression scale (EPDS). La interacción madre-hijo fue evaluada y codificada con la Escala de Observación del Vínculo Madre-Bebé Hospitalizados. Resultados: las madres de bebés prematuros moderados hospitalizados en una unidad de neonatología pueden presentar una importante sintomatología depresiva y ésta se correlaciona con el estrés experimentado por la madre. El estrés parental y el ser pequeño para la edad gestacional evidenciaron una asociación negativa con las interacciones de las diadas. Conclusiones: El tener un bebé prematuro moderado puede impactar la salud mental de las madres y esto a su vez se relaciona con las interacciones que tienen con sus hijos/as. Del mismo modo se detectaron variables relacionadas con los bebés que también pueden disminuir las interacciones y contacto entre la diada.</jats:p>
      1Scopus© Citations 2  1
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    The Impact of an Interactive Guidance Intervention on Sustained Social Withdrawal in Preterm Infants in Chile: Randomized Controlled Trial
    (2022)
    Jorge Bustamante Loyola
    ;
    Marcela Pérez Retamal
    ;
    Andrés Mendiburo-Seguel
    ;
    Antoine Claude Guedeney
    ;
    Ricardo Salinas González
    <jats:sec><jats:title>Background</jats:title><jats:p>Sustained social withdrawal is a key indicator of child emotional distress and a risk factor for psychological development. Preterm infants have a higher probability of developing sustained social withdrawal than infants born full-term during their first year.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To compare the effect of a behavioral guidance intervention to that of routine pediatric care on sustained social withdrawal behavior in preterm infants.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Multicenter randomized clinical trial.</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>Ninety nine moderate and late preterm newborns and their parents were recruited and randomized into two groups, i.e., Intervention (<jats:italic>n</jats:italic> = 49) and Control (<jats:italic>n</jats:italic> = 50). Both groups attended medical check-ups at 2, 6 and 12 months and were assessed with the Alarm Distress Baby Scale. The intervention group received a standardized behavioral intervention if the neonatologist detected sustained social withdrawal. Also, parents filled out the Edinburgh Postnatal Depression Scale, the modified-Perinatal Posttraumatic Stress Disorder Questionnaire, and the Impact of Event Scale-revised.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>At baseline, the prevalence of withdrawal was 4.0% (95% CI: 0.03–14.2) for the control group and 22.4% (95% CI: 13.0–35.9) for the intervention group [OR = 0.22, <jats:italic>p</jats:italic> = 0.028 (95% CI =0.06–0.84)]. At 6 months, the prevalence was 10.0% (95% CI: 3.9–21.8) for the control group and 6.1% (95% CI: 2.1–16.5) for the intervention group [OR = 2.09, <jats:italic>p</jats:italic> = 0.318 (95% CI = 0.49–8.88)]. At 12 months, the prevalence was 22.0% (95% CI: 12.8–35.2) for the control group and 4.1% (95% CI: 1.1–13.7) for the intervention group [OR = 6.63, <jats:italic>p</jats:italic> = 0.018 (95% CI = 1.39–31.71)]. Logistic generalized estimating equation models were performed. The pooled crude OR (considering diagnosis at 6 and 12 months) was 3.54 [<jats:italic>p</jats:italic> = 0.022 (95% CI = 1.20–10.44); Cohen's d= 0.70]. In the case of pooled adjusted OR, the model considered diagnosis (0 = Withdrawal, 1 = Normal) as the dependent variable, time of evaluation (1= 6 months, 2 = 12 months) and group (0 = Control, 1 = Experimental) as factors. In this case, the pooled adjusted OR was 3.57 [<jats:italic>p</jats:italic> = 0.022 (95% CI = 1.20–10.65); Cohen's d = 0.70].</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Assessment and intervention of sustained social withdrawal in preterm infants via standardized instruments benefits families by reducing its prevalence, and possible associated negative outcomes.</jats:p></jats:sec><jats:sec><jats:title>Clinical Trial Registration</jats:title><jats:p>ClinicalTrials.gov; <jats:ext-link>https://clinicaltrials.gov/ct2/show/NCT03212547</jats:ext-link>, identifier: NCT03212547.</jats:p></jats:sec>
    Scopus© Citations 1  1
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    Childhood adversity increases risk of psychotic experiences in patients with substance use disorder
    (2022)
    Ignacio Bórquez-Infante
    ;
    Javiera Vasquez
    ;
    Sofía Dupré
    ;
    Eduardo A. Undurraga
    ;
    Nicolás A. Crossley
    Scopus© Citations 10  4