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    Bespoke science: the use of ad hoc scientific advisory committees in the Covid-19 pandemic
    (Springer Science and Business Media LLC, 2025-06-19)
    Roger Koppl
    ;
    Kira Pronin
    ;
    Nick Cowen
    ;
    Marta Podemska-Mikluch
    ;
    PANIAGUA PRIETO, PABLO IGNACIO  
    Many governments formed ad hoc scientific advisory committees in the Covid-19 pandemic because they offered the government greater control over policy advice than standing agencies. The difference between ad hoc and standing advisory bodies has been little noted in the literature. High-uncertainty crises demanding expertise and requiring action from the national government increase the value of policy discretion, raising the value of controlling the scientific narrative. An ad hoc body is generally easier to control than a standing body because policymakers have greater liberty to choose its members, specify its mandate, and disband and reconstitute it when needed. Control generally requires either a narrow membership or a narrow mandate. If members cannot be chosen to be reliably aligned with the government or its policy preferences, a narrow mandate will restrain the committee from offering undesired advice or analysis. Our argument builds on the public choice assumption of motivational symmetry: The choices of scientists and politicians are shaped by the same motives and desires that influence individuals in any other sphere of life. Our case studies of Italy, UK, US, Poland, Uganda, and Sweden support our theory.
    Scopus© Citations 2  3
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    Resilience of mobility network to dynamic population response across COVID-19 interventions: Evidences from Chile
    (Public Library of Science (PLoS), 2025-02-20)
    Pasquale Casaburi
    ;
    Lorenzo Dall’Amico
    ;
    Nicolò Gozzi
    ;
    Kyriaki Kalimeri
    ;
    Anna Sapienza
    The COVID-19 pandemic highlighted the importance of non-traditional data sources, such as mobile phone data, to inform effective public health interventions and monitor adherence to such measures. Previous studies showed how socioeconomic characteristics shaped population response during restrictions and how repeated interventions eroded adherence over time. Less is known about how different population strata changed their response to repeated interventions and how this impacted the resulting mobility network. We study population response during the first and second infection waves of the COVID-19 pandemic in Chile and Spain. Via spatial lag and regression models, we investigate the adherence to mobility interventions at the municipality level in Chile, highlighting the significant role of wealth, labor structure, COVID-19 incidence, and network metrics characterizing business-as-usual municipality connectivity in shaping mobility changes during the two waves. We assess network structural similarities in the two periods by defining mobility hotspots and traveling probabilities in the two countries. As a proof of concept, we simulate and compare outcomes of an epidemic diffusion occurring in the two waves. While differences exist between factors associated with mobility reduction across waves in Chile, underscoring the dynamic nature of population response, our analysis reveals the resilience of the mobility network across the two waves. We test the robustness of our findings recovering similar results for Spain. Finally, epidemic modeling suggests that historical mobility data from past waves can be leveraged to inform future disease spatial invasion models in repeated interventions. This study highlights the value of historical mobile phone data for building pandemic preparedness and lessens the need for real-time data streams for risk assessment and outbreak response. Our work provides valuable insights into the complex interplay of factors driving mobility across repeated interventions, aiding in developing targeted mitigation strategies.
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    Scopus© Citations 1  1
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    Emergency Department Workflow Times of Intravenous Thrombolysis with Tenecteplase versus Alteplase in Acute Ischemic Stroke: A Prospective Cohort Study before and during the COVID-19 Pandemic
    (S. Karger AG, 2025-02-03)
    Matias Guzman
    ;
    LAVADOS GERMAIN, PABLO MANUEL  
    ;
    Gabriel Cavada
    ;
    Alejandro M. Brunser
    ;
    Veronica V. Olavarria
    Introduction: Tenecteplase (TNK) has demonstrated to be non-inferior to alteplase (ALT) for intravenous thrombolysis (IVT) in acute ischemic stroke (AIS). There are potential workflow benefits associated with TNK use, aiming to reduce patient length of stay in the emergency department. Our aim was to investigate whether the routine use of TNK during the COVID-19 pandemic influenced workflow times compared to historical use of ALT, while maintaining non-inferior clinical outcomes in a non-drip and ship scenario of a comprehensive stroke center. Methods: We included patients with AIS admitted from September 2019 to September 2022 and compared those treated with TNK during the COVID-19 pandemic to those treated with ALT in the period immediately before. We compared emergency department length of stay (EDLOS), door-to-needle time (DTN), door-to-groin puncture time (DTG), clinical and safety outcomes with adjusted general linear regression models. Results: 110 patients treated with TNK and 111 with ALT were included in this study. Mean EDLOS was 251 (SD = 164) min for TNK users versus 240 (SD = 148) min for ALT (p = 0.62). Mean DTN was 43 (SD = 25) min for TNK versus 46 (SD = 27) min for ALT users (p = 0.39). Mean DTN under 60 min was achieved in 86 (78.2%) patients and in 85 (76.5%) patients of the TNK and ALT groups, respectively (p = 1.0). DTN under 45 min was achieved in 65.4% and 58.6% (p = 0.65) of the TNK and ALT groups, respectively. DTG time was 114 (SD = 43) min for TNK versus 111 (58 = SD) min in the ALT group (p = 0.88). DTG under 90 min was achieved in 32% of the TNK group and 35% of the ALT group (p = 0.69). There were no differences in any of the clinical or safety outcomes between groups at 90 days. Conclusions: The adoption of TNK during COVID-19 pandemic did not result in a change in EDLOS, DTN, or DTG times when compared to ALT in this cohort. Safety and clinical outcomes were similar between groups. Probably a greater benefit could have been seen in a drip and ship thrombolysis setting. Further research is needed to assess the potential advantages of TNK in drip and ship scenarios of IVT.
    Scopus© Citations 2  2
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    Reducing global inequities in medical oxygen access: the Lancet Global Health Commission on medical oxygen security
    (Elsevier BV, 2025-03)
    Hamish R Graham
    ;
    Carina King
    ;
    Ahmed Ehsanur Rahman
    ;
    Freddy Eric Kitutu
    ;
    Leith Greenslade
    Scopus© Citations 53  1
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    Socioeconomic inequalities in Chile during the COVID-19 pandemic: A regional analysis of income poverty
    (Public Library of Science (PLoS), 2025-05-07)
    DELGADO BECERRA, OROZIMBA IRIS  
    ;
    Sushma Dahal
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    MATUTE WILLEMSEM, MARIA ISABEL  
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    RUBILAR RAMIREZ, PAOLA ANDREA  
    ;
    Svenn-Erik Mamelund
    The COVID-19 pandemic caused an unprecedented economic crisis, intensifying poverty levels in Latin America, particularly in Chile. This study examines the short- and long-term socioeconomic impacts of COVID-19 on income poverty in Chile, focusing on regional disparities, rurality, ethnicity, educational attainment, and immigration. Using data from the Chile National Socioeconomic Characterization Survey (CASEN) for 2017, 2020, and 2022, we analyzed poverty trends across the pre-pandemic, pandemic, and post-pandemic periods. We employed spatial clustering techniques with Local Moran’s I to detect poverty hotspots and applied logistic regression models to identify key sociodemographic factors associated with these hotspots. Our results reveal stark regional disparities, with disproportionately higher poverty rates among rural populations, Indigenous communities, and individuals with lower education levels or immigrant backgrounds. The proportion of individuals in poverty hotspots rose from 6.8% in 2017 to 8.6% in 2020, before slightly declining to 7.7% in 2022. Although emergency monetary subsidies helped reduce overall poverty from 10.8% in 2020 to 6.5% in 2022, these measures were insufficient to address deep-rooted structural inequalities. Our findings underscore the urgent need for targeted, long-term policies that go beyond temporary financial assistance and tackle systemic disparities linked to rurality, ethnicity, education, and immigration. Such measures are essential for achieving sustainable poverty reduction and fostering inclusive economic growth in Chile.
    Scopus© Citations 1  1
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    The role of the behavioral immune system in the expression of short and long-term orientation in young Chilean men during the COVID-19 pandemic
    (Springer Science and Business Media LLC, 2025-02-07)
    FIGUEROA VALDEBENITO, ORIANA CRISTINA  
    ;
    POLO RODRIGO, PABLO  
    ;
    Daniel Torrico-Bazoberry
    ;
    Gabriela Fajardo  
    ;
    RODRÍGUEZ SICKERT, CARLOS ANDRÉS  
    The COVID-19 pandemic drastically changed people's lives. It had consequences at the individual and social level. The behavioral immune system predicts that when faced with the risk of contagion from pathogens, people tend to reduce their sociality, especially sociosexuality. We examine this prediction by evaluating decreases in the pandemic of the different dimensions of sociosexuality of young men (i.e., short and long-term mating orientation, sexual desire, and sociosexual behavior) and considering their relationship status (single or paired). Methods and materials We compared data from two cross-sectional studies carried out in the laboratory with convenience sampling methods in the pre-pandemic period (in the years 2016 and 2018 with a sample size of N = 463) and pandemic (face-to-face panstudy N = 234,data online, N = 182), considering possible differences between samples of the same period. We reached an N = 879 young men who answered a sociodemographic questioarticipants answered a sociodemographic questionnaire that inclnnaire and the Multidimensional Sociosexual Orientation Inventory. To test our predictions, we fitted general linear models. Results point to a significant decrease in long-term mating orientation in paired and single men, but only when compared with the pandemic face-to-face study. In addition, no differences were found for short-term mating orientation. For sociosexual desire (i.e., sexual fantasies), we found a reduction in single pre-pandemic individuals to be compared with the sample of pandemic online study. Finally, we found a decrease in sociosexual behavior (i.e., number of partners in the last year) between pre-pandemic samples and the pandemic itself, regardless of their relationship status and samples inside of each period. In addition, we carry out analyses with a reduced sample to re-test our predictions based on the perception of contagion risk (measured by a survey from OMS). We find changes are maintained at the level of sociosexual desire and sexual behavior but mainly in those individuals with a greater perception of the risk of contagion. The hypotheses derived from the behavioral immune system regarding the decrease in sociosexuality in a context of risk of contagion by pathogens, as was the case in the initial period of COVID-19, are corroborated only in terms of desire and behavior, which suggests a certain stability in attitudes i.e., the menace of contagion modifies proximal aspects of sociosexuality, such as fantasies and behavior, but has no apparent effect on the calibration of the predisposition of individuals to varying levels of commitment in sexual relationships. These findings will allow us to understand better how the dimensions of sociosexuality (i.e., fantasies, attitudes and behavior) are affected when there are contexts of high risk of contagion, such as COVID-19. These findings will allow us to understand better how sociosexuality is affected when there are contexts of high risk of contagion, such as COVID-19.
    Scopus© Citations 1  1
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    Scopus© Citations 6  5
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    Factors associated with loneliness in Latin-American family care partners during the COVID-19 pandemic
    (2024)
    Tomas Leon
    ;
    Thamara Tapia-Munoz
    ;
    SLACHEVSKY CHONCHOL, ANDREA MARÍA  
    ;
    Bárbara Costa Beber
    ;
    Fernando Aguzzoli
    <jats:sec><jats:title>Background</jats:title><jats:p>COVID-19-related restrictions led to an increase in overall loneliness and social isolation. Before the pandemic, care partners reported higher levels of loneliness and higher loneliness prevalence compared to non-care partners. Because of the spread and severity of the infections, and the access to support spread, we expect a different impact of the COVID-19 pandemic on LATAM care partners.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>To describe the loneliness levels of LATAM caregivers and to identify socioeconomic and health factors associated.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>An international online cross-sectional survey for care partners, embedded within the ‘Coping with Loneliness and Isolation during COVID-19’ (CLIC) Study conducted between June 2020– and November 2020.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>We analysed data from 246 family care partners living in Latin American countries (46% Mexico, 26% Chile,18% Brazil, and 10% from Argentina, Peru, Venezuela, Panama, Guatemala y Costa Rica).</jats:p></jats:sec><jats:sec><jats:title>Measurements</jats:title><jats:p>We assessed loneliness using the 6-items of De Jong Gierveld loneliness Scale. We described the levels of overall, emotional, and social loneliness pre and during Covid, and reported the distribution of care partners who improved, worsened or maintained their levels of loneliness. Moreover, we used longitudinal multiple linear regression models with bootstraps errors of 1,000 iterations to identify factors associated with the levels of overall, emotional, and social loneliness during the pandemic.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Participants were mostly women, 50 years and older, in a partnership, highly educated and with finances meeting their needs, with good to excellent physical and mental health. Among the total of care partners, 55% perceived higher overall loneliness, 56% higher emotional loneliness, and 21% higher social loneliness during the pandemic in comparison with pre-COVID-19 levels. Perceived mental health was associated with the overall, emotional, and social loneliness.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Regardless of their living and health situation, during the pandemic, loneliness increased in all groups of care partners. These should be taken in consideration when planning public health approaches for crises such as pandemics or other large-scale disruptive events.</jats:p></jats:sec>
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    Class, gender and the work of working-class women amid turbulent times
    (2024-01-01)
    Warren, Tracey  
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    TORRES RETAMAL, LUIS DARIO  
    ;
    Lyonette, Clare  
    ;
    Tarlo, Ruth  
    The article focuses on the work of working-class women (WCW) amid turbulent times. Its timespan is just prior to and during the Covid-19 pandemic in the UK. The women's work, and the key skills involved, are fundamental to everyday lives, but both have been under-valued and under-rewarded. The pandemic shone a fresh light on the societal importance of this work and highlighted how its under-valuation and the women's systemic low pay and inferior working conditions have serious ramifications not only for individual workers and their families but for the provision of key services. The article centres WCW, at the intersection of classed and gendered disadvantage, to ask about inequalities in work experiences. Analysing nationally representative samples of thousands of workers in the UK prior to and as Covid-19 rolled out, we compare WCW with other workers. We show that the women faced both persistent and new inequalities at work: enduring low earnings, pandemic-led risks to jobs and paid hours, little opportunity to work from home or flexibly, and stressful key working roles. We reveal the heavily classed nature of some of these findings, show that others were more strongly gendered, while still others were classed and gendered outcomes that require intersectional analyses of the women's working lives.
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