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Efficacy of platelet-rich-fibrin for the treatment of alveolar osteitis: a systematic review and meta-analysis
(Medicina Oral, S.L., 2025)
C. Ávila-Oliver
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V. Veloso
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G. Laissle
;
AM. Rojas
;
F. Verdugo-Paiva
2
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Assessment of redundancy, methodological and reporting quality, and potential discrepancies of results of systematic reviews of early mobilisation of critically ill adults: a meta-research protocol
(2023)
Ruvistay Gutierrez-Arias
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Dawid Pieper
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Peter Nydahl
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Felipe González-Seguel
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Yorschua Jalil
<jats:sec><jats:title>Introduction</jats:title><jats:p>Several systematic reviews (SRs) have been conducted to determine the effectiveness of early mobilisation in critically ill adults with heterogeneous methodology and results. Redundancy in conducting SRs, unclear justification when leading new SRs or updating, and discordant results of SRs on the same research question may generate research waste that makes it difficult for clinicians to keep up to date with the best available evidence. This meta-research aims to assess the redundancy, methodological and reporting quality, and potential reasons for discordance in the results reported by SRs conducted to determine the effectiveness of early mobilisation in critically ill adult patients.</jats:p></jats:sec><jats:sec><jats:title>Methods and analysis</jats:title><jats:p>A meta-research of early mobilisation SRs in critically ill adult patients will be conducted. A search of MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCOhost), Cochrane Library, Epistemonikos and other search resources will be conducted. Two independent reviewers will perform study selection, data extraction and quality appraisal. Discrepancies will be resolved by consensus or a third reviewer. The redundancy of SRs will be assessed by the degree of overlap of primary studies. In addition, the justification for conducting new SRs will be evaluated with the ‘Evidence-Based Research’ framework. The methodological quality of the SRs will be assessed with the A MeaSurement Tool to Assess systematic Reviews 2 tool, and the quality of the reports through compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. To assess the potential reasons for discordance in the results of the SRs considering divergence in results and their interpretation.</jats:p></jats:sec><jats:sec><jats:title>Ethics and dissemination</jats:title><jats:p>As meta-research, this study does not involve the participation of people whose rights may be violated. However, this overview will be developed rigorously and systematically to achieve valid and reliable results. The findings of this meta-research study will be presented at conferences and published in a peer-reviewed journal related to rehabilitation, critical care or research methodology.</jats:p></jats:sec><jats:sec><jats:title>Trial registration number</jats:title><jats:p>osf.io/kxwq9.</jats:p></jats:sec>
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Predictive Validity of Developmental Screening Questionnaires for Identifying Children With Later Cognitive or Educational Difficulties: A Systematic Review
(2021)
SCHONHAUT, LUISA
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MATURANA PEREA, ANDRES
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Olenkha Cepeda
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Pamela Serón
<jats:p><jats:bold>Context:</jats:bold> Parent/caregiver completing developmental screening questionnaires (DSQs) for children before 5 years of age is currently recommended. The DSQs recommended by the American Academy of Pediatrics (AAP) are the Ages and Stages Questionnaires (ASQ), Parents' Evaluation of Developmental Status (PEDS), and the Survey of Well-being of Young Children (SWYC). Nevertheless, their predictive validity has not been well-established.</jats:p><jats:p><jats:bold>Objective:</jats:bold> To assess in the current literature, the value of AAP-recommended DSQs (ASQ, PEDS, SWYC) administered between 0 and 5 years of age, for predicting long-term cognitive achievement and/or school performance (CA/SP), after 1 year or more of evaluation and at/or after age 5 years, in the general population.</jats:p><jats:p><jats:bold>Data Sources:</jats:bold> Cochrane, MEDLINE PubMed, CINAHL, EMBASE, Web of Science, Scielo, and Scopus databases (until March 2021).</jats:p><jats:p><jats:bold>Study Selection:</jats:bold> Two authors selected the studies. Forward and backward citation follow-up was done; authors of DSQ were contacted to identify additional studies.</jats:p><jats:p><jats:bold>Data Extraction:</jats:bold> Cohorts were identified, and authors of selected studies were contacted to corroborate and complete extracted data.</jats:p><jats:p><jats:bold>Results:</jats:bold> Thirty-two publications, corresponding to 10 cohorts, were included. All cohorts used ASQ. Only cohort using PEDS was identified but did not meet the inclusion criteria. No cohorts conducted with SWYC were identified. Associations between ASQ and CA/SP were extracted for eight cohorts. The odds ratios were <jats:underline>&gt;</jats:underline>3, and the area under the curve was 0.66–0.87. A trade-off between sensitivity and specificity was observed.</jats:p><jats:p><jats:bold>Limitations:</jats:bold> Heterogeneity in population characteristics and in DSQ adaptations.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold> A positive association between ASQ and later CA/SP was found in different social, cultural, and economic settings. Additional studies are necessary to determine the impact factors in the predictive capacity of DSQs.</jats:p><jats:p><jats:bold>Systematic Review Registration:</jats:bold> PROSPERO, identifier: CRD42020183883.</jats:p>
Scopus© Citations 8 1 1
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Effectiveness of physical rehabilitation interventions in critically ill patients—A protocol for an overview of systematic reviews
(2023)
Ruvistay Gutierrez-Arias
;
Peter Nydahl
;
Dawid Pieper
;
Felipe González-Seguel
;
Yorschua Jalil
<jats:sec id="sec001"> <jats:title>Introduction</jats:title> <jats:p>Adult and pediatric patients admitted to intensive care units (ICUs) requiring invasive ventilatory support, sedation, and muscle blockade may present neuromusculoskeletal deterioration. Different physical rehabilitation interventions have been studied to evaluate their effectiveness in improving critically ill patients’ outcomes. Given that many published systematic reviews (SRs) aims to determine the effectiveness of different types of physical rehabilitation interventions, it is necessary to group them systematically and assess the methodological quality of SRs to help clinicians make better evidence-based decisions. This overview of SRs (OoSRs) aims to map the existing evidence and to determine the effectiveness of physical rehabilitation interventions to improve neuromusculoskeletal function and other clinical outcomes in adult and pediatric critically ill patients.</jats:p> </jats:sec> <jats:sec id="sec002"> <jats:title>Methods</jats:title> <jats:p>An OoSRs of randomized and non-randomized clinical trials involving critically ill adult and pediatric patients receiving physical rehabilitation intervention will be conducted. A sensitive search of MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCOhost), Cochrane Library, Epistemonikos, and other search resources will be conducted. Two independent reviewers will conduct study selection, data extraction, and methodological quality assessment. Discrepancies will be resolved by consensus or a third reviewer. The degree of overlap of studies will be calculated using the corrected covered area. The methodological quality of the SRs will be measured using the AMSTAR-2 tool. The GRADE framework will report the certainty of evidence by selecting the "best" SR for each physical rehabilitation intervention and outcome.</jats:p> </jats:sec> <jats:sec id="sec003"> <jats:title>Discussion</jats:title> <jats:p>The findings of this overview are expected to determine the effectiveness and safety of physical rehabilitation interventions to improve neuromusculoskeletal function in adult and pediatric critically ill patients based on a wide selection of the best available evidence and to determine the knowledge gaps in this topic by mapping and assessing the methodological quality of published SRs.</jats:p> </jats:sec> <jats:sec id="sec004"> <jats:title>Registration number</jats:title> <jats:p><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023389672" xlink:type="simple">CRD42023389672</jats:ext-link>.</jats:p> </jats:sec>
20Scopus© Citations 1
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Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2
(2020)
Raúl Bustos B
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Juan Camilo Jaramillo-Bustamante
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Pablo Vasquez-Hoyos
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Pablo Cruces
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Franco Díaz
13Scopus© Citations 24
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AN ANALYTICAL REVIEW OF CONTRIBUTORY FACTORS IN INTERVERTEBRAL DISC DEGENERATION
(2022)
Vishal Kumar
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Deepak Neradi
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Shivam Maheshwari
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Guisela Quinteros
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YURAC BARRIENTOS, RATKO JOVAN
<jats:p>ABSTRACT Objective: To summarize current trends in the pathogenesis and management of disc degeneration and suggest areas where more research would be of benefit. Methods: The available literature relevant to Lumbar disc degeneration (LDD) was reviewed. PubMed, MEDLINE, OVID, EMBASE, Cochrane, and Google Scholar databases were used to review the literature. Institutional Review Board approval was not applicable for this study. Results: This article summarizes trends in the pathogenesis and factors associated with disc degeneration. Conclusions: The genetic contribution to lumbar disc degeneration is a newer concept, still being researched in different populations around the world. Investigators have demonstrated a familial predisposition in the etiology of lumbar disc degeneration. The effect sizes of most genetic variants are small and, thus, individual gene-environment studies must have very large sample sizes to provide compelling evidence of any interaction. Level of evidence; Narrative review of available literature.</jats:p>
22Scopus© Citations 1
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Salud de migrantes internacionales en situación irregular: una revisión narrativa de iniciativas
(2019)
Daniel Larenas-Rosa
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CABIESES VALDES, BALTICA BEATRIZ
Scopus© Citations 7 2

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