AN ANALYTICAL REVIEW OF CONTRIBUTORY FACTORS IN INTERVERTEBRAL DISC DEGENERATION
Journal
Coluna/Columna
ISSN
2177-014X
1808-1851
Date Issued
2022
Author(s)
Vishal Kumar
Deepak Neradi
Shivam Maheshwari
Guisela Quinteros
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>ABSTRACT Objective: To summarize current trends in the pathogenesis and management of disc degeneration and suggest areas where more research would be of benefit. Methods: The available literature relevant to Lumbar disc degeneration (LDD) was reviewed. PubMed, MEDLINE, OVID, EMBASE, Cochrane, and Google Scholar databases were used to review the literature. Institutional Review Board approval was not applicable for this study. Results: This article summarizes trends in the pathogenesis and factors associated with disc degeneration. Conclusions: The genetic contribution to lumbar disc degeneration is a newer concept, still being researched in different populations around the world. Investigators have demonstrated a familial predisposition in the etiology of lumbar disc degeneration. The effect sizes of most genetic variants are small and, thus, individual gene-environment studies must have very large sample sizes to provide compelling evidence of any interaction. Level of evidence; Narrative review of available literature.</jats:p>
Subjects
aging
;
environment
;
epidemiology
;
genetics
;
collagen type 1
;
collagen type 1 a1
;
stromelysin
;
unclassified drug
;
age
;
analytic method
;
col9a2 gene
;
demographics
;
dna polymorphism
;
embase
;
familial predisposition
;
gene
;
genetic variability
;
genotype environment interaction
;
human
;
intervertebral disk degeneration
;
lifestyle
;
low back pain
;
medline
;
narrative
;
pathogenesis
;
review
;
risk factor
;
sex
;
systematic review
;
trend study