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New Dermoscopy Pattern in Nevus‐Associated Melanomas
(Wiley, 2025-04-19)
Nelson Lobos‐Guede
;
Dan Hartmann
;
Valentina Darlic
;
Cristina Carrera
;
Llucia Alos
Melanomas can appear de novo or in association with a pre‐existing nevus. The association of melanomas with pre‐existing nevi and its role as a melanoma precursor is a controversial issue. Dermoscopy can increase melanoma's diagnostic accuracy and help us suspect nevus‐associated melanomas (NAM). Differentiating NAMs clinically and dermoscopically can be challenging. There are few published studies so far describing dermoscopic features of NAM that have differentiated from <jats:italic>de novo</jats:italic> melanomas, such as multi‐component pattern, multifocal pigmentation, atypical pigment network, regression structures, negative pigment network, irregular globules, and streaks. Here, we report four acquired compound NAMs showing a starburst pattern (SP) within the lesion. No publications have reported NAMs with melanoma components in the form of SP arising within the center of the lesion. Therefore, when faced with a compound or intradermal nevus with incipient central reticulated pigmentation, especially if there is no history of trauma or previous surgery, we must pay alert to the possibility of an early development of melanoma.
2
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The Role of MicroRNAs in Breast Cancer and the Challenges of Their Clinical Application
(2023)
Juan P. Muñoz
;
Pablo Pérez-Moreno
;
Yasmín Pérez
;
Gloria M. Calaf
<jats:p>MicroRNAs (miRNAs) constitute a subclass of non-coding RNAs that exert substantial influence on gene-expression regulation. Their tightly controlled expression plays a pivotal role in various cellular processes, while their dysregulation has been implicated in numerous pathological conditions, including cancer. Among cancers affecting women, breast cancer (BC) is the most prevalent malignant tumor. Extensive investigations have demonstrated distinct expression patterns of miRNAs in normal and malignant breast cells. Consequently, these findings have prompted research efforts towards leveraging miRNAs as diagnostic tools and the development of therapeutic strategies. The aim of this review is to describe the role of miRNAs in BC. We discuss the identification of oncogenic, tumor suppressor and metastatic miRNAs among BC cells, and their impact on tumor progression. We describe the potential of miRNAs as diagnostic and prognostic biomarkers for BC, as well as their role as promising therapeutic targets. Finally, we evaluate the current use of artificial intelligence tools for miRNA analysis and the challenges faced by these new biomedical approaches in its clinical application. The insights presented in this review underscore the promising prospects of utilizing miRNAs as innovative diagnostic, prognostic, and therapeutic tools for the management of BC.</jats:p>
Scopus© Citations 52
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Patient and Carer Experiences with Bladder Cancer: Results from a Global Survey in 45 Countries
(2023)
Lydia E. Makaroff
;
Alex Filicevas
;
Shannon Boldon
;
Patrick Hensley
;
Peter C. Black
7Scopus© Citations 8
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In-Hospital Acute Ischemic Stroke is Associated with Worse Outcome: Experience of a Single Center in Santiago Chile
(2021)
BRUNSER RABOVICH, ALEJANDRO MICHEL
;
Patricia Araneda
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NAVIA GONZALEZ, VICTOR HUGO
;
MAZZON AGURTO, ENRICO
;
Gabriel Cavada
3Scopus© Citations 8
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Variability of quantitative measurements of metastatic liver lesions: a multi-radiation-dose-level and multi-reader comparison
(2020)
Yuqin Ding
;
Daniele Marin
;
Federica Vernuccio
;
GONZALEZ COFRE, FERNANDO OMAR
;
Hannah V. Williamson
Scopus© Citations 4 3
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Endobronchial ultrasound- guided transbronchial needle aspiration for mediastinal lymph node staging in patients with typical pulmonary carcinoids
(2020)
Macarena R. Vial
;
Faria Nasim
;
Henriette De La Garza
;
David E. Ost
;
Roberto F. Casal
12Scopus© Citations 4
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Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis
(2021)
Pamela R. de Santiago
;
Alejandro Blanco
;
Fernanda Morales
;
Katherine Marcelain
;
Olivier Harismendy
2Scopus© Citations 38
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Direct‐Acting Antivirals and Hepatocellular Carcinoma: No Evidence of Higher Wait‐List Progression or Posttransplant Recurrence
(2020)
Federico Piñero
;
Ilka Boin
;
Aline Chagas
;
Emilio Quiñonez
;
Sebastián Marciano
7Scopus© Citations 15
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Consenso chileno de diagnóstico y manejo de neoplasias quísticas pancreáticas. Club de páncreas Chile-SCHGE
(2021)
Alberto Espino
;
José Ignacio Vargas
;
Carla Mancilla
;
Pablo Muñoz
;
Waldo Martínez
1 4
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Concordance Analysis of ALK Gene Fusion Detection Methods in Patients with Non–Small-Cell Lung Cancer from Chile, Brazil, and Peru
(2021)
Gonzalo Sepúlveda-Hermosilla
;
Matías Freire
;
Alejandro Blanco
;
Javier Cáceres
;
Rodrigo Lizana
1Scopus© Citations 6

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